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The results provide the first evidence that a specific isoform of beta-tubulin is required for mitosis.[beta5 tubulin]
Methylation in the beta-tubulin TUBB6 correlated with the presence of dysplasia and accurately discriminated between dysplasia and nondysplastic tissue, even in the apparently normal field mucosa downstream from dysplastic lesions. Methylation in TUBB6 is a potential biomarker for Ulcerative colitis (UC) - associated dysplasia.
Findings enlarge the spectrum of tubulinopathies and emphasize that mutations of TUBB6 should be considered in patients with congenital non-progressive facial palsy.
TUBB6 is an inhibitor of pyroptosis.
Data indicate that leucine-rich repeat kinase 2 (LRRK2) selectively interacts with three beta-tubulin isoforms: TUBB, TUBB4, and TUBB6.
betaV-tubulin expression is a potentially promising prognostic marker of malignancy.
in colorectal cancer patients, there was a link between poor survival, the expression of TUBB3/TUBB6, and androgen receptor only in females
The TUBB6 expression was largely decreased in most tumors.
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain.
tubulin beta-6 chain
, tubulin, beta 6
, tubulin beta-6 chain-like
, class V beta-tubulin
, tubulin beta MGC4083
, tubulin beta class V
, beta tubulin6
, uncharacterized protein LOC550458
, LOW QUALITY PROTEIN: tubulin beta-6 chain