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anti-Human CDC7 Antibodies:
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Human Polyclonal CDC7 Primary Antibody for WB - ABIN1882165
Sato, Arai, Masai: Human and Xenopus cDNAs encoding budding yeast Cdc7-related kinases: in vitro phosphorylation of MCM subunits by a putative human homologue of Cdc7. in The EMBO journal 1997
Show all 4 Pubmed References
Human Monoclonal CDC7 Primary Antibody for ICC, IF - ABIN265783
Hubbi, Kshitiz, Gilkes, Rey, Wong, Luo, Kim, Dang, Levchenko, Semenza: A nontranscriptional role for HIF-1α as a direct inhibitor of DNA replication. in Science signaling 2013
Human Polyclonal CDC7 Primary Antibody for IHC (p) - ABIN4296982
Kitamura, Fukatsu, Kakusho, Cho, Taniyama, Yamazaki, Toh, Yanagi, Arai, Chang, Masai: Molecular mechanism of activation of human Cdc7 kinase: bipartite interaction with Dbf4/activator of S phase kinase (ASK) activation subunit stimulates ATP binding and substrate recognition. in The Journal of biological chemistry 2011
Both CDC7 and DBF4 (show DBF4 Antibodies) promoters bind E2F (show E2F1 Antibodies), suggesting that increased E2F (show E2F1 Antibodies) activity in RB1 (show RB1 Antibodies) mutant cancers promotes increased DDK expression. Surprisingly, increased DDK expression levels are also correlated with both increased chemoresistance and genome-wide mutation frequencies.
p53 (show TP53 Antibodies)-dependent control of CDC7 levels is essential for blocking G1/S cell-cycle transition upon genotoxic stress.
we propose that phosphorylation of TOP2A (show TOP2A Antibodies) by CDC7/DBF4 (show DBF4 Antibodies) in early S-phase prevents its localization and/or activity at centromeres, and inhibition of TOP2A (show TOP2A Antibodies) function could be relevant to prevent premature separation of centromeric DNA.
The data support a model where Cdc7 (de)phosphorylation is the molecular switch for the activation and inactivation of DNA replication in mitosis, directly connecting Cdc7 and PP1a (show PPP1CA Antibodies)/Cdk1 (show CDK1 Antibodies) to the regulation of once-per-cell cycle DNA replication in mammalian cells.
Our data show that Cdc7 is highly expressed in colorectal cancer
The presence of the index SNP rs1192415 (TGFBR3 (show TGFBR3 Antibodies)-CDC7) was associated with visual field progression in POAG (primary open-angle glaucoma) patients.
MiR (show MLXIP Antibodies)-630 promoted apoptosis by downregulation of CDC7.
The state of DUE-B phosphorylation is maintained by the equilibrium between Cdc7-dependent phosphorylation and PP2A (show PPP2R4 Antibodies)-dependent dephosphorylation.
The interaction between Claspin (show CLSPN Antibodies) and Cdc7 is not dependent on Cdc7 kinase activity, but Claspin (show CLSPN Antibodies) interaction with the DNA helicase subunit Mcm2 (show MCM2 Antibodies) is lost upon Cdc7 inhibition.
huCdc7 may play an important role in the development and progression of colorectal cancer.
Cdc7 physically and functionally interacts with Nkx2.5 (show NKX2-5 Antibodies) to regulate Myocd (show MYOCD Antibodies) promoter activity
Cdc7 mediates SMC (show DYM Antibodies) differentiation through a mechanism distinct from cell proliferation.
MCM4 (show MCM4 Antibodies) phosphorylation by Cdc7 kinase facilitates its interaction with Cdc45 (show CDC45 Antibodies) on chromatin
This gene encodes a cell division cycle protein with kinase activity that is critical for the G1/S transition. The yeast homolog is also essential for initiation of DNA replication as cell division occurs. Overexpression of this gene product may be associated with neoplastic transformation for some tumors. Multiple alternatively spliced transcript variants that encode the same protein have been detected.
cell division cycle 7-related protein kinase
, CDC7 (cell division cycle 7, S. cerevisiae, homolog)-like 1
, CDC7-related kinase
, cell division cycle 7 homolog
, cell division cycle 7-like protein 1
, cell division cycle 7-like 1