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Higher expression of CDC7 in odontogenic keratocyst (OKC) and radicular cyst was shown in comparison to dentigerous cyst, while radicular cyst and OKC groups showed no difference in CDC7 expression.
Results suggest a new role of Claspin in initiation of DNA replication during normal S phase through the recruitment of Cdc7 that facilitates phosphorylation of Mcm proteins.
Increased Cdc7-dependent replication initiation is a hallmark of p53 (show TP53 Proteins) gain-of function mutations in lung adenocarcinoma.
Both CDC7 and DBF4 (show DBF4 Proteins) promoters bind E2F (show E2F1 Proteins), suggesting that increased E2F (show E2F1 Proteins) activity in RB1 (show RB1 Proteins) mutant cancers promotes increased DDK expression. Surprisingly, increased DDK expression levels are also correlated with both increased chemoresistance and genome-wide mutation frequencies.
p53 (show TP53 Proteins)-dependent control of CDC7 levels is essential for blocking G1/S cell-cycle transition upon genotoxic stress.
we propose that phosphorylation of TOP2A (show TOP2A Proteins) by CDC7/DBF4 (show DBF4 Proteins) in early S-phase prevents its localization and/or activity at centromeres, and inhibition of TOP2A (show TOP2A Proteins) function could be relevant to prevent premature separation of centromeric DNA.
The data support a model where Cdc7 (de)phosphorylation is the molecular switch for the activation and inactivation of DNA replication in mitosis, directly connecting Cdc7 and PP1a (show PPP1CA Proteins)/Cdk1 (show CDK1 Proteins) to the regulation of once-per-cell cycle DNA replication in mammalian cells.
Our data show that Cdc7 is highly expressed in colorectal cancer
The presence of the index SNP rs1192415 (TGFBR3 (show TGFBR3 Proteins)-CDC7) was associated with visual field progression in POAG (primary open-angle glaucoma) patients.
MiR (show MLXIP Proteins)-630 promoted apoptosis by downregulation of CDC7.
Cdc7 physically and functionally interacts with Nkx2.5 to regulate Myocd promoter activity
Cdc7 mediates SMC (show DYM Proteins) differentiation through a mechanism distinct from cell proliferation.
MCM4 (show MCM4 Proteins) phosphorylation by Cdc7 kinase facilitates its interaction with Cdc45 (show CDC45 Proteins) on chromatin
This gene encodes a cell division cycle protein with kinase activity that is critical for the G1/S transition. The yeast homolog is also essential for initiation of DNA replication as cell division occurs. Overexpression of this gene product may be associated with neoplastic transformation for some tumors. Multiple alternatively spliced transcript variants that encode the same protein have been detected.
cell division cycle 7-related protein kinase
, CDC7 (cell division cycle 7, S. cerevisiae, homolog)-like 1
, CDC7-related kinase
, cell division cycle 7 homolog
, cell division cycle 7-like protein 1
, cell division cycle 7-like 1