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Human Monoclonal DBF4 Primary Antibody for IF, ELISA - ABIN564742
Hughes, Jenkins, Dar, Engelman, Cherepanov: Transcriptional co-activator LEDGF interacts with Cdc7-activator of S-phase kinase (ASK) and stimulates its enzymatic activity. in The Journal of biological chemistry 2009
Mouse (Murine) Polyclonal DBF4 Primary Antibody for ELISA, WB - ABIN4304355
Tsuji, Lau, Chiang, Jiang: The role of Dbf4/Drf1-dependent kinase Cdc7 in DNA-damage checkpoint control. in Molecular cell 2008
Both CDC7 (show CDC7 Antibodies) and DBF4 promoters bind E2F (show E2F1 Antibodies), suggesting that increased E2F (show E2F1 Antibodies) activity in RB1 (show RB1 Antibodies) mutant cancers promotes increased DDK expression. Surprisingly, increased DDK expression levels are also correlated with both increased chemoresistance and genome-wide mutation frequencies.
Histone H3 (show HIST3H3 Antibodies) lysine 9 (H3K9) acetylation was most prevalent when the Dbf4 transcription level was highest whereas the H3K9me3 level was greatest during and just after replication.
we propose that phosphorylation of TOP2A (show TOP2A Antibodies) by CDC7 (show CDC7 Antibodies)/DBF4 in early S-phase prevents its localization and/or activity at centromeres, and inhibition of TOP2A (show TOP2A Antibodies) function could be relevant to prevent premature separation of centromeric DNA.
The anti-invasive and cell cycle arrest-inducing effects of nitrogen-containing bisphosphonates are not DBF4 mediated in human breast cancer cells.
Dbf4 is direct downstream target of ataxia telangiectasia mutated (ATM) and ataxia telangiectasia and Rad3-related (ATR) protein to regulate intra-S-phase checkpoint.
bipartite interaction between Cdc7 (show CDC7 Antibodies) and Dbf4/ASK subunits facilitates ATP binding and substrate recognition by the Cdc7 (show CDC7 Antibodies) kinase.
Dbf4 regulates the Cdc5 (show CDC5L Antibodies) Polo-like kinase (show PLK1 Antibodies) through a distinct non-canonical binding interaction
Data document the role of DBF4 as a key player in nitrogen-containing bisphosphonate-induced cytotoxicity, thus explaining the effects on the cell-cycle.
The interaction with LEDGF (show PSIP1 Antibodies) relieves autoinhibition of Cdc7 (show CDC7 Antibodies)-ASK kinase, imposed by the C terminus of ASK.
results suggest that E2F (show E2F1 Antibodies) regulates the ASK promoter through an atypical mode of recognition of the target site
Regulatory subunit for cdc7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Not required during the initiation of DNA replication in egg and during early embryonic development but is required later and throughout development. The complex cdc7-dbf4a phosphorylates mcm2 subunit.
DBF4-type zinc finger-containing protein 1
, activator of S phase kinase
, chiffon homolog A
, protein DBF4 homolog A
, zinc finger, DBF-type containing 1
, DBF4 homolog (S. cerevisiae)
, protein DBF4 homolog A-like
, DBF4 homolog