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anti-Human Dihydrofolate Reductase Antibodies:
anti-Mouse (Murine) Dihydrofolate Reductase Antibodies:
anti-Rat (Rattus) Dihydrofolate Reductase Antibodies:
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Human Monoclonal Dihydrofolate Reductase Primary Antibody for IF, ELISA - ABIN560600
Ionova, Vásquez-Vivar, Whitsett, Herrnreiter, Medhora, Cooley, Pieper: Deficient BH4 production via de novo and salvage pathways regulates NO responses to cytokines in adult cardiac myocytes. in American journal of physiology. Heart and circulatory physiology 2008
Show all 6 Pubmed References
Dog (Canine) Monoclonal Dihydrofolate Reductase Primary Antibody for IF, IP - ABIN968118
de Wind, Dekker, Claij, Jansen, van Klink, Radman, Riggins, van der Valk, vant Wout, te Riele: HNPCC-like cancer predisposition in mice through simultaneous loss of Msh3 and Msh6 mismatch-repair protein functions. in Nature genetics 1999
Show all 5 Pubmed References
Dog (Canine) Monoclonal Dihydrofolate Reductase Primary Antibody for IF, IP - ABIN968119
Eymin, Gazzeri, Brambilla, Brambilla: Distinct pattern of E2F1 expression in human lung tumours: E2F1 is upregulated in small cell lung carcinoma. in Oncogene 2001
Show all 5 Pubmed References
The heat induced inactivation of DHFR follows first-order kinetics and Arrhenius law. The variation in the value of inactivation rate constant k with increasing temperatures depicts faster inactivation at elevated temperatures. Attempted to study the chaperoning ability of a shorter variant of GroEL (show GroEL Antibodies) (minichaperone) and compared it with that of conventional GroEL (show GroEL Antibodies)-GroES (show HSPE1 Antibodies) chaperone system.
A comparative study of various species of DHFR shows that zDHFR has comparable thermodynamic stability with human counterpart and thus proved to be a good in vitro model system for structure- function relationship studies.
Dihydrofolate reductase is required for the development of heart and outflow tract in zebrafish.
Dihydrofolate reductase and thymidylate synthase (show TYMS Antibodies) form a complex in vitro and co-localize in normal and cancer cells.
Single nucleotide polymorphism in DHFR gene is associated with Systemic lupus erythematosus.
study concludes polymorphism 63/91 in DHFR gene promoter can modulate the onset of methotrexate-related adverse effects in rheumatoid arthritis patients
our findings suggest that the identification of DHFR polymorphisms in the promoter region of the gene may be helpful in tailoring MTX (show MTX1 Antibodies) doses for ALL pediatric patients on maintenance therapy.
The abundance of dihydrofolate reductase was statistically significantly increased in rheumatoid arthritis (RA)-patient biopsies compared with controls and correlated with the administered dosage of methotrexate (MTX (show MTX1 Antibodies)), the most frequently prescribed immunosuppressive drug for RA.
The present study demonstrated that ADAR1 (show ADAR Antibodies) positively regulates the expression of DHFR by editing the miR (show MLXIP Antibodies)-25-3p and miR (show MLXIP Antibodies)-125a-3p binding sites in the 3'-UTR (show UTS2R Antibodies) of DHFR, enhancing cellular proliferation and resistance to methotrexate in MCF-7 cells.
In conclusion, the finding suggests that folate nutrition and 19bp del-DHFR [Dihydrofolate reductase] variation may interact to modify adenomatous polyp [colorectal cancer] risk.
the highest expression of GGH (show GGH Antibodies) and EGFR (show EGFR Antibodies) was noted in the left-sided colon; the highest expression of DHFR, FPGS (show FPGS Antibodies), TOP1 (show TOP1 Antibodies) and ERCC1 (show ERCC1 Antibodies) was noted in the rectosigmoid, whereas TYMP (show TYMP Antibodies) expression was approximately equivalent in the right-sided colon and rectum
Overexpression of miR (show MLXIP Antibodies)-192 inhibited cellular proliferation by binding DHFR. miR (show MLXIP Antibodies)-192 decreased cellular anchoring via the repression of ITGAV (show ITGAV Antibodies), ITGB1 (show ITGB1 Antibodies), ITGB3 (show ITGB3 Antibodies), and CD47 (show CD47 Antibodies)
Data suggest that DHFR exhibits intrinsic activity kinetics that are temperature-independent; additional mass (i.e., incorporation of H, C, and N isotopes) has no effect on intrinsic activity kinetics or protein conformation/stability of DHFR.
The study reports arrested hematopoiesis and vascular relaxation defects in mice with a point mutation, Thr136Ala substitution in Dhfr.
S-nitrosylation of DHFR at cysteine 7 by eNOS (show NOS3 Antibodies)-derived NO is crucial for DHFR stability.
demonstrate that dihydrofolate reductase activity is also a feature of the mitochondria in both rat and mouse but this is not due to a second enzyme
Robust and processive unfolding/degradation of some substrates with very stable protein domains, including mDHFR and titin (show TTN Antibodies)(I27) .
protects endothelial nitric oxide synthase (show NOS3 Antibodies) from uncoupling in tetrahydrobiopterin deficiency
Dhfr has a role in folate regulation of axonal regeneration in the rodent central nervous system through DNA methylation (show HELLS Antibodies)
E2F (show E2F1 Antibodies)-responsive dihydrofolate reductase promoter regulates the balance between acetylation and methylation of histone H3 (show HIST3H3 Antibodies) lysine 9
translocation of the DHFR domain was greatly impaired when it was separated from the signal-anchor sequence
mechanical stability of mouse dihydrofolate reductase is dominated by local interactions within the protein structure
Crystal structures are reported for NADPH (show FDXR Antibodies) ternary complexes with PY1011 and mouse DHFR (mDHFR), refined to 2.2 A resolution.
Hydrogen peroxide down regulates expression in response to angiotensin Ii and underlies endothelial nitric oxide synthase (show NOS3 Antibodies) dysfunction.
Dihydrofolate reductase converts dihydrofolate into tetrahydrofolate, a methyl group shuttle required for the de novo synthesis of purines, thymidylic acid, and certain amino acids. While the functional dihydrofolate reductase gene has been mapped to chromosome 5, multiple intronless processed pseudogenes or dihydrofolate reductase-like genes have been identified on separate chromosomes. Dihydrofolate reductase deficiency has been linked to megaloblastic anemia.
, dihydrofolate reductase DhfR
, Dihydrofolate reductase
, Dihydrofolate reductase 1 (active)