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Human Polyclonal MAT1A Primary Antibody for ICC, IF - ABIN4332790
Yang, Cho, Li, Peng, Ko, Mato, Lu: MicroRNAs regulate methionine adenosyltransferase 1A expression in hepatocellular carcinoma. in The Journal of clinical investigation 2013
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Cow (Bovine) Polyclonal MAT1A Primary Antibody for WB - ABIN2776786
Oh, Yang, Hahn, Kim, Byun, Jeon, Kim, Song, Noh, Kim, Yoo, Kim, Kim: Transcriptome analysis of human gastric cancer. in Mammalian genome : official journal of the International Mammalian Genome Society 2005
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Human Polyclonal MAT1A Primary Antibody for IHC (p), WB - ABIN656632
Bing, Zhu, Yu, Li, Liu, Li, Wang, Qi, Guo, Yuan, He, Liu, Liu: Glucocorticoid-induced S-adenosylmethionine enhances the interferon signaling pathway by restoring STAT1 protein methylation in hepatitis B virus-infected cells. in The Journal of biological chemistry 2014
interplay between MATalpha1, c-Myc (show MYC Antibodies), and Maf (show MAF Antibodies) proteins, and their deregulation during chronic cholestasis may facilitate cholangiocarcinoma oncogenesis
Of the 22 single nucleotide polymorphisms studied, the rs8193 polymorphism lying in the micro-RNA binding site of 3'-UTR (show UTS2R Antibodies) of CD44 (show CD44 Antibodies) was significantly (P=.0270) associated with RT-induced adverse skin reactions. Generalized multifactor dimensionality reduction analysis showed significant (P=.0107) gene-gene interactions between MAT1A and CD44 (show CD44 Antibodies).
A compound mutation of the methionine adenosyltransferase 1A (MAT1A) gene, c.345delA and c.529C>T, was identified in the patient, and His father and mother were found to be heterozygous for the c.345delA mutation and c.529C>T mutation, respectively.
S-adenosyl-L-methionine (show AS3MT Antibodies) diminishes hepatitis C virus expression by altering MAT1A/2A signaling in hepatocytes.
5-Aza-CdR (show RUNX1T1 Antibodies) showed no effects on MAT2A (show MAT2A Antibodies) methylation.
The mutations in the other 10 patients showed autosomal recessive inheritance and included eight novel MAT1A mutations.
Liver-specific isoenzyme MAT1A is genetically linked with an inborn metabolic disorder of hypermethioninemia, as well as a ubiquitously expressed isoenzyme MAT2A (show MAT2A Antibodies), whose enzymatic activity is regulated by an associated subunit MAT2B (show MAT2B Antibodies).
Methionine adenosyltransferase I/III deficiency is caused by mutations in the MAT1A gene. (Review)
upregulation of miR (show MLXIP Antibodies)-664, miR (show MLXIP Antibodies)-485-3p, and miR (show MLXIP Antibodies)-495 contributes to lower MAT1A expression in HCC (show FAM126A Antibodies), and enhanced tumorigenesis may provide potential targets for HCC (show FAM126A Antibodies) therapy.
Report SNPs that are highly associated with hepatic GNMT (show GNMT Antibodies) protein expression and the coordinate regulation of MAT1A levels.
MAT1A is required for normal VLDL assembly and plasma lipid homeostasis in mice. Impaired VLDL synthesis, mainly due to SAMe deficiency, contributes to NAFLD (show TSC2 Antibodies) development in MAT1A-KO mice.
DUSP1 (show DUSP1 Antibodies) mRNA and protein levels are lower in Mat1a knockout livers and fall rapidly in cultured hepatocytes.
Spontaneous oxidative stress and liver tumors in mice lacking methionine adenosyltransferase 1A
MAT1A knockout hepatocytes have more baseline DNA synthesis but no mitogenic response to hepatocyte growth factor (show HGF Antibodies). MAT1A-produced SAMe has a major role in ERK (show EPHB2 Antibodies) signaling & cyclin D1 (show CCND1 Antibodies) regulation during liver regeneration & mitogenic signal response.
Mat1a(-/-) mice have expansion of liver stem cells as they age. These cells have increased expression of several oncogenes and are tumorigenic in vivo.
C/EBPbeta (show CEBPB Antibodies) plays an important role in epigenetic regulation of the mature hepatic gene MAT1A
By 1 month of age, genomic instability increases in livers of Mat1a knockout mice, possibly due to reduced APEX1 (show APEX1 Antibodies) levels
CD133(+)CD45(-) oval cells isolated from premalignant 16-month-old Mat1a(-/-) mice demonstrated significant resistance to transforming growth factor-beta-induced apoptosis compared to CD133(-) cells.
This gene catalyzes a two-step reaction that involves the transfer of the adenosyl moiety of ATP to methionine to form S-adenosylmethionine and tripolyphosphate, which is subsequently cleaved to PPi and Pi. S-adenosylmethionine is the source of methyl groups for most biological methylations. The encoded protein is found as a homotetramer (MAT I) or a homodimer (MAT III) whereas a third form, MAT II (gamma), is encoded by the MAT2A gene. Mutations in this gene are associated with methionine adenosyltransferase deficiency.
, S-adenosylmethionine synthase isoform type-1
, S-adenosylmethionine synthetase isoform type-1
, adoMet synthase 1
, adoMet synthetase 1
, methionine adenosyltransferase 1
, methionine adenosyltransferase I/III
, S - adenosylmethionine synthetase