Browse our MCM8 Proteins (MCM8)

Full name:: Minichromosome Maintenance Deficient 8 Proteins (MCM8)

On www.antibodies-online.com are 4 Minichromosome Maintenance Deficient 8 (MCM8) Proteins from 2 different suppliers available. Additionally we are shipping MCM8 Antibodies (69) and and many more products for this protein. A total of 85 MCM8 products are currently listed.

Synonyms:: 5730432L01Rik, C20orf154, dJ967N21.5

list all proteins	Gene Name	GeneID	UniProt
	MCM8	84515	Q9UJA3
Rat MCM8	MCM8	296178
	MCM8	66634	Q9CWV1
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MCM8 Proteins (MCM8) by Origin

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Top referenced MCM8 Proteins

Human MCM8 Protein expressed in Wheat germ - ABIN1310565 : Henderson, Hall, Prpic, Hessling, Parker, Sampson, Simkins, Brough, Dixon, Lenz, Knapp, Murphy, Taylor, Fischer, Malinowski: The selection and characterization of antibodies to minichromosome maintenance proteins that highlight cervical dysplasia. in Journal of immunological methods 2011 (PubMed)

More Proteins for MCM8 Interaction Partners

Human Minichromosome Maintenance Deficient 8 (MCM8) interaction partners

Additional support to the view that MCM8 mutations are involved in the primary ovarian insufficiency phenotype.
stalled replication forks can be restarted in S phase via homologous recombination using MCM8-9 as an alternative replicative helicase.
study showed that copy number increase and overexpression of MCM8 may play critical roles in human cancer development.
Significant number of potentially damaging and novel variants in MCM8 in primary ovarian insufficiency; multiallelic association with variants in DDR (show DDR1 Proteins) and MCM8-MCM9 (show MCM9 Proteins) interactome genes.
Novel mutations p. H317L and p. H601R in the MCM8 gene are potentially causative for primary ovarian insufficiency by dysfunctional DNA repair.
Suggest role for MCM8 in the pathogenesis of chronic myelogenous leukemia.
MCM8, a component of the pre-replication complex, is crucial for gonadal development and maintenance in humans-both males and females. These
An autosomal recessive ovarian failure disorder caused by an MCM8 mutation that manifests with endocrine dysfunction and genomic instability.
Chromatin immunoprecipitation analysis using human DR-GFP cells demonstrated that MCM8 and MCM9 (show MCM9 Proteins) proteins are rapidly recruited to DNA damage sites and promote RAD51 (show RAD51 Proteins) recruitment.
Single Nucleotide Polymorphism in MCM8 is associated with ovarian follicle number and menopause.

Xenopus laevis Minichromosome Maintenance Deficient 8 (MCM8) interaction partners

Mcm8 and Mcm9 (show MCM9 Proteins) form a dimeric complex in Xenopus laevis egg extract that is not essential for DNA replication initiation.
MCM8 functions in the elongation step of DNA replication as a helicase that facilitates the recruitment of RPA34 and stimulates the processivity of DNA polymerases at replication foci.

Mouse (Murine) Minichromosome Maintenance Deficient 8 (MCM8) interaction partners

MCM8 and MCM9 (show MCM9 Proteins) form a complex and that they coregulate their stability.

MCM8 Protein Profile

Protein Summary

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein contains the central domain that is conserved among the MCM proteins. This protein has been shown to co-immunoprecipitate with MCM4, 6 and 7, which suggests that it may interact with other MCM proteins and play a role in DNA replication. Alternatively spliced transcript variants encoding distinct isoforms have been described.

Alternative names and synonyms associated with MCM8

minichromosome maintenance 8 homologous recombination repair factor (MCM8)
minichromosome maintenance 8 homologous recombination repair factor (Mcm8)
minichromosome maintenance 8 homologous recombination repair factor L homeolog (mcm8.L)

5730432L01Rik protein
C20orf154 protein
dJ967N21.5 protein

Protein level used designations for MCM8

DNA helicase MCM8 , DNA replication licensing factor MCM8 , MCM8 minichromosome maintenance deficient 8 , REC homolog , minichromosome maintenance 8 , minichromosome maintenance deficient 8 , Minichromosome maintenance 8

GENE ID	SPECIES
84515	Homo sapiens
421314	Gallus gallus
477163	Canis lupus familiaris
507507	Bos taurus
296178	Rattus norvegicus
734487	Xenopus laevis
66634	Mus musculus

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