Browse our MCM8 Proteins (MCM8)

Human Minichromosome Maintenance Deficient 8 (MCM8) interaction partners

1. Conceptual MCM8-9 inhibitors will be powerful cancer-specific chemosensitizers for platinum compounds.

2. Additional support to the view that MCM8 mutations are involved in the primary ovarian insufficiency phenotype.

3. stalled replication forks can be restarted in S phase via homologous recombination using MCM8-9 as an alternative replicative helicase.

4. study showed that copy number increase and overexpression of MCM8 may play critical roles in human cancer development.

5. Significant number of potentially damaging and novel variants in MCM8 in primary ovarian insufficiency; multiallelic association with variants in DDR and MCM8-MCM9 interactome genes.

6. Novel mutations p. H317L and p. H601R in the MCM8 gene are potentially causative for primary ovarian insufficiency by dysfunctional DNA repair.

7. Suggest role for MCM8 in the pathogenesis of chronic myelogenous leukemia.

8. MCM8, a component of the pre-replication complex, is crucial for gonadal development and maintenance in humans-both males and females. These

9. An autosomal recessive ovarian failure disorder caused by an MCM8 mutation that manifests with endocrine dysfunction and genomic instability.

10. Chromatin immunoprecipitation analysis using human DR-GFP cells demonstrated that MCM8 and MCM9 proteins are rapidly recruited to DNA damage sites and promote RAD51 recruitment.

11. Single Nucleotide Polymorphism in MCM8 is associated with ovarian follicle number and menopause.

12. Single nucleotide polymorphism in MCM8 is associated with menopause and the length of reproductive lifespan.

13. The MCM8 gene is located contrapodal to GCD10 at chromosome band 20p12.3-13.

14. MCM8 is a crucial component of the pre-RC and that the interaction between hMCM8 and hcdc6 is required for pre-RC assembly.

15. We find that MCM8, like MCM7, colocalizes on a specific DNA segment of the c-MYC replication initiation zone (c-MYC replicator) of DNA replications together with Cdc6 and cdk2, but differs with MCM7 in spatial relation to RPA70 during S phase.

Xenopus laevis Minichromosome Maintenance Deficient 8 (MCM8) interaction partners

1. Mcm8 and Mcm9 form a dimeric complex in Xenopus laevis egg extract that is not essential for DNA replication initiation.

2. MCM8 functions in the elongation step of DNA replication as a helicase that facilitates the recruitment of RPA34 and stimulates the processivity of DNA polymerases at replication foci.

Mouse (Murine) Minichromosome Maintenance Deficient 8 (MCM8) interaction partners

1. MCM8 and MCM9 form a complex and that they coregulate their stability.