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Browse our anti-ORC6 (ORC6) Antibodies

Full name:: anti-Origin Recognition Complex, Subunit 6 Antibodies (ORC6)

On www.antibodies-online.com are 71 Origin Recognition Complex, Subunit 6 (ORC6) Antibodies from 18 different suppliers available. Additionally we are shipping ORC6 Proteins (9) and and many more products for this protein. A total of 93 ORC6 products are currently listed.

Synonyms:: 6720420I10Rik, ARABIDOPSIS THALIANA ORIGIN RECOGNITION COMPLEX PROTEIN 6, ATORC6, CG1584, DDBDRAFT_0186183, DDBDRAFT_0233113, DDB_0186183, DDB_0233113, Dmel\\CG1584, DmORC 6, DmORC6, LOC100284755, ORC, orc6, orc6l, origin recognition complex protein 6, ORIGIN RECOGNITION COMPLEX SUBUNIT 6, rDmORC, T2P11.3, T2P11_3

list all antibodies	Gene Name	GeneID	UniProt
	ORC6	291927
	ORC6	23594	Q9Y5N6
	ORC6	56452
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Top referenced anti-ORC6 Antibodies

Human Monoclonal ORC6 Primary Antibody for ChIP, IP - ABIN108574 : Ritzi, Tillack, Gerhardt, Ott, Humme, Kremmer, Hammerschmidt, Schepers: Complex protein-DNA dynamics at the latent origin of DNA replication of Epstein-Barr virus. in Journal of cell science 2003 (PubMed)

More Antibodies against ORC6 Interaction Partners

Fruit Fly (Drosophila melanogaster) Origin Recognition Complex, Subunit 6 (ORC6) interaction partners

The interaction of the Drosophila ENY2 protein with the ORC complex subunits was investigated. It is found that ORC4 and ORC6 subunits directly interact with ENY2.
In order to study the effects of Meier-Gorlin syndrome (MGS) mutation in an animal model system, MGS mutation in Orc6 was introduced and established Drosophila model of MGS.
Drosophila Orc6 protein, the smallest subunit of the origin recognition complex (ORC), directly binds to septin complex and facilitates septin filament formation.
Drosophila ORC6 protein cytokinetic function resides in a domain distinct from its replication activity
These studies provide a molecular analysis for the functional requirement of Orc6 in replicative functions of ORC in Drosophila and suggest that Orc6 may contribute to the sequence preferences of ORC in targeting to the origins.
These results show that the interaction of Orc6 with the septin complex is dependent on the coiled-coil domain of Pnut, and suggest an active role for Orc6 in septin complex function.
In a cross-species complementation experiment, the expression of human Orc6 in Drosophila Orc6 mutant cells rescued DNA replication, suggesting that this function of the protein is conserved among metazoans.

Human Origin Recognition Complex, Subunit 6 (ORC6) interaction partners

The 11-year-old boy with Meier-Gorlin syndrome (MGS) has a homozygous mutation in origin recognition complex, subunit 6 (ORC6) gene mapped to chromosome 16, and his father with heterozygote carrier of ORC6 gene.
The present report expands the clinical phenotype associated with ORC6 mutations to include severely abnormal embryological development suggesting a possible genotype-phenotype correlation.
our results suggest that Meier-Gorlin syndrome mutations in Orc6 impair the formation of ORC hexamers, interfering with appropriate ORC functions
findings show that Orc6 not only interacts with Orc1-Orc5 but also with the initiation factor Cdc6, and that Orc6 functions at different stages of the replication initiation process.
Structural analysis of human Orc6 protein reveals a homology with transcription factor TFIIB.
results implicate Orc6 as an essential gene that coordinates chromosome replication and segregation with cytokinesis
Study using HCT116 haplo-insufficient cells and Orc2 hypomorphic cells demonstrates that the binding of human Ku to replication origins precedes that of Orc-3, -4, and -6 subunit binding.
Orc6 has a role in sensitizing human colon cancer cells to 5-fluorouracil and cisplatin
In a cross-species complementation experiment, the expression of human Orc6 in Drosophila Orc6 mutant cells rescued DNA replication, suggesting that this function of the protein is conserved among metazoans.
Functional studies of the Drosophila homolog
Functional studies of the yeast homolog

Mouse (Murine) Origin Recognition Complex, Subunit 6 (ORC6) interaction partners

Study reports that ORC6L is another component required for acquisition of DNA replication competence that is absent in mouse oocytes.

ORC6 Antigen Profile

Antigen Summary

The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Gene silencing studies with small interfering RNA demonstrated that this protein plays an essential role in coordinating chromosome replication and segregation with cytokinesis.

Alternative names and synonyms associated with ORC6

origin recognition complex, subunit 6 (Orc6) antibody
Origin recognition complex subunit 6 (Orc6) antibody
origin recognition complex subunit 6 (ORC6) antibody
origin recognition complex protein 6 (ORC6) antibody
origin recognition complex subunit 6 (CpipJ_CPIJ005016) antibody
origin recognition complex subunit Orc6 (SJAG_01267) antibody
origin recognition complex subunit 6 (orcF) antibody
origin recognition complex subunit 6 (LOC100284755) antibody
origin recognition complex subunit 6 (orc6) antibody

6720420I10Rik antibody
ARABIDOPSIS THALIANA ORIGIN RECOGNITION COMPLEX PROTEIN 6 antibody
ATORC6 antibody
CG1584 antibody
DDBDRAFT_0186183 antibody
DDBDRAFT_0233113 antibody
DDB_0186183 antibody
DDB_0233113 antibody
Dmel\\CG1584 antibody
DmORC 6 antibody
DmORC6 antibody
LOC100284755 antibody
ORC antibody
orc6 antibody
orc6l antibody
origin recognition complex protein 6 antibody
ORIGIN RECOGNITION COMPLEX SUBUNIT 6 antibody
rDmORC antibody
T2P11.3 antibody
T2P11_3 antibody

Protein level used designations for ORC6

origin recognition complex subunit 6 , origin recognition complex, subunit 6-like , CG1584-PA , Orc6-PA , origin recognition complex, subunit 6 like

GENE ID	SPECIES
291927	Rattus norvegicus
36017	Drosophila melanogaster
415749	Gallus gallus
465140	Pan troglodytes
839227	Arabidopsis thaliana
6036630	Culex quinquefasciatus
7048414	Schizosaccharomyces japonicus yFS275
8624765	Dictyostelium discoideum AX4
100284755	Zea mays
549939	Xenopus (Silurana) tropicalis
23594	Homo sapiens
482492	Canis lupus familiaris
515476	Bos taurus
56452	Mus musculus

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