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Study found that PKMYT1 was essential for the proliferation and mobility of CRC (show CALR Proteins) cells in vitro. Also, results demonstrated that patients expressing high level of PKMYT1 displayed a worse overall survival rate than those with a low level of PKMYT1. These data indicated that PKMYT1 was a biomarker for the prediction of the prognosis of the disease.
PKMYT1 positively regulated the growth, migration, colony formation, metastasis and epithelia mesenchymal transition of hepatocellular carcinoma cells
Myt1 (show MYT1 Proteins) is inactivated by MEK1 (show MAP2K1 Proteins) mediated phosphorylation to fragment the Golgi complex in G2 and for the entry of cells into mitosis.
MYT1 (show MYT1 Proteins) binds to TSAP6 (show STEAP3 Proteins) in tumor cells and has a role in cell cycle regulation
Myt1 is phosphorylated by polo-like kinase 1
the induction of Cdc2 (show CDK1 Proteins) phosphorylation due to the increase of Wee1 (show WEE1 Proteins) and Myt1 (show MYT1 Proteins) as well as the reduction of Cdc2 (show CDK1 Proteins) and cyclin B1 (show CCNB1 Proteins) are involved in 1,25[OH]2VD3-induced G2/M arrest of keratinocytes.
The results show that Myt1 (show MYT1 Proteins)-mediated suppression of Cdc2 (show CDK1 Proteins) activity is not indispensable for the regulation of a broad range of mitotic events but is specifically required for the control of intracellular membrane dynamics during mitosis in Hela cells.
Data show that CDK1 (show CDK1 Proteins) and cyclin B synergize during oocyte maturation to inhibit Myt1 ensuring meiotic progression.
Study propose a model in which the appearance of active MPF (show MSLN Proteins) complexes following increased Cyclin B synthesis causes Myt1 inhibition, upstream of the MPF (show MSLN Proteins)/Cdc25 (show CDC25C Proteins) amplification loop.
Autophosphorylation of Myt1 is a novel inhibitory mechanism that adds another layer of complexity to the phosphorylation-dependent mechanism of Myt1 regulation.
XRINGO-activated CDKs can phosphorylate specific residues in the regulatory domain of Myt1.
This gene encodes a member of the serine/threonine protein kinase family. The encoded protein is a membrane-associated kinase that negatively regulates the G2/M transition of the cell cycle by phosphorylating and inactivating cyclin-dependent kinase 1. The activity of the encoded protein is regulated by polo-like kinase 1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
, protein kinase Myt1
, protein kinase, membrane associated tyrosine/threonine 1
, membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase-like
, myt1 kinase
, MYT1 kinase
, membrane-associated tyrosine-and threonine-specific cdc2-inhibitory kinase