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these results provide a novel insight into the role of PP2A (show PPP2R4 Proteins)-B55alpha as a novel meiotic and embryonic competence factor at the onset of life.
we propose that the Smad4 (show SMAD4 Proteins)-Pitx2 (show PITX2 Proteins)-PPP2R2A axis, a new signaling pathway, suppresses the pancreatic carcinogenesis
These data unravel B55alpha as a PHD2 (show EGLN1 Proteins) substrate and highlight a role for PHD2 (show EGLN1 Proteins)-B55alpha in the response to nutrient deprivation.
results suggest that PR55alpha promotes pancreatic cancer development by sustaining hyperactivity of multiple oncogenic signaling pathways, including AKT (show AKT1 Proteins), ERK (show EPHB2 Proteins), and Wnt (show WNT2 Proteins)
miR-222 targets protein phosphatase 2A subunit B in bladder cancer cells.
miR (show MLXIP Proteins)-556-5p functions as an onco-miRNA and participates in prostate cancer carcinogenesis by suppressing PPP2R2A expression.
Concurrent mTORC1 inactivation and PP2A (show PPP2R4 Proteins)-B55alpha stimulation fuel ULK1 (show ULK1 Proteins)-dependent autophagy.
Data show that breast cancer (BC) with PPP2R2A deletions are associated with worse overall survival, and the combination of altered PPP2R2A and high CCND1 (show CCND1 Proteins) expression define a subgroup of luminal-like BC patients with a high risk of relapse and death.
overexpression of miR (show MLXIP Proteins)-892a may provide a selective growth promotion for colorectal cancer cells by direct suppression of PPP2R2A expression.
miR (show MLXIP Proteins)-136 may play an important role during TGF-beta1 (show TGFB1 Proteins)-induced proliferation arrest by targeting PPP2R2A in keratinocytes.
Data suggest IGT10 mice, diabetes type 2 model, exhibit 2 genetic defects: haploinsufficiency (heterozygosity for null allele) of insulin receptor (Insr (show INSR Proteins)); splice-site mutation in protein phosphatase 2 regulatory subunit B alpha (Ppp2r2a). Inheritance of either allele results in insulin (show INS Proteins) resistance but not overt diabetes. Double heterozygosity leads to insulin (show INS Proteins) resistance and diabetes type 2 without increase in body weight.
Concurrent mTORC1 inactivation and PP2A (show PPP2R2B Proteins)-B55alpha stimulation fuel ULK1 (show ULK1 Proteins)-dependent autophagy.
FBXL16 (show FBXL16 Proteins) negatively regulates the activity of B55alpha-PP2A (show PPP2R2B Proteins) to modulate the genesis of FLK1 (show KDR Proteins)+ progenitor cells.
Ppp2r2a is required for Connexin-43 (show GJA1 Proteins) dephosphorlyation during epidermal barrier acquisition
The B55alpha-EDD-p53 pathway is essential for cancer cell survival and tumor growth under low glutamine conditions in vitro and in vivo.
that B55alpha-dependent targeting of the PP2A (show PPP2R2B Proteins) holoenzyme to Akt (show AKT1 Proteins) selectively regulates Akt (show AKT1 Proteins) phosphorylation at Thr (show TRH Proteins)-308 to regulate cell proliferation and survival.
PP-2A is less abundant than PP-1 in the mouse eye and appear to be highly regulated by various regulatory subunits; the genes encoding PP-1alpha/beta, PP-2Aalpha/beta, PP-2A-Aalpha/beta, and PP-2A-B alpha/beta/gamma are all differentially expressed.
Phosphorylation of T231 (AT180) can negatively influence the dephosphorylation of the pS202/pT205 AT8 epitope, even without an altered PP2A (show PPP2R2B Proteins) pool.
The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes an alpha isoform of the regulatory subunit B55 subfamily. Alternatively spliced transcript variants have been described.
protein phosphatase 2 (formerly 2A), regulatory subunit B (PR52), alpha isoform
, serine/threonine protein phosphatase 2A, 55 KDA regulatory subunit B, alpha isoform
, serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform
, PP2A subunit B isoform B55-alpha
, PP2A subunit B isoform BRA
, PP2A subunit B isoform PR55-alpha
, PP2A subunit B isoform R2-alpha
, PP2A subunit B isoform alpha
, PP2A, subunit B, B-alpha isoform
, PP2A, subunit B, B55-alpha isoform
, PP2A, subunit B, BRA isoform
, PP2A, subunit B, PR55-alpha isoform
, PP2A, subunit B, R2-alpha isoform
, protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), alpha isoform
, protein phosphatase 2 (formerly 2A), regulatory subunit B, alpha isoform
, protein phosphatase 2A 55 kDa regulatory subunit, alpha isoform
, protein phosphatase 2, regulatory subunit B, alpha