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In thyroid hemiagenesis, genomic examinations revealed the presence of four recurrent defects (three deletions and one duplication) affecting highly conservative proteasome genes PSMA1, PSMA3 (show PSMA3 Proteins), and PSMD3 (show PSMD3 Proteins).
Data indicate that RNA interference screens identified PSMA1, a component of the 20S proteasome (show PSMA5 Proteins) as target of non-small cell lung cancer (NSCLC) cytotoxicity.
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits\; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
proteasome (prosome, macropain) subunit, alpha type, 1
, proteasome subunit alpha type-1
, proteasome subunit alpha type 1
, 20S proteasome subunit alpha-1
, 20S proteasome subunit C2
, macropain subunit C2
, multicatalytic endopeptidase complex subunit C2
, proteasome component C2
, proteasome nu chain
, proteasome alpha 1 subunit
, 30 kDa prosomal protein
, macropain subunit nu
, proteasome subunit nu
, proteasome subunit, alpha-type, 1
, protein P30-33K
, proteasome subunit alpha type
, 20s proteasome
, proteasome 35
, proteasome 35 kD subunit
, proteasome 35-kDa subunit
, proteasome 35kD subunit
, proteasome 35kDa subunit