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Selective upregulation of the ubiquitin-proteasome proteolytic pathway proteins, proteasome zeta chain and isopeptidase T (show USP5 Antibodies) in fetal Down syndrome.
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits\; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been found for this gene.
, proteasome alpha subunit
, proteasome alpha5 subunit
, proteasome subunit alpha type 5
, hypothetical protein
, macropain zeta chain
, multicatalytic endopeptidase complex zeta chain
, proteasome subunit alpha type-5
, proteasome zeta chain
, proteasome alpha 5 subunit
, macropain subunit zeta
, proteasome component 5
, proteasome subunit zeta
, proteasome subunit, alpha type, 5