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Dog (Canine) Monoclonal PSMA6 Primary Antibody for FACS, WB - ABIN2729910
Khan, Pediaditakis, Malakhau, Esmaeilniakooshkghazi, Ashkavand, Sereda, Krupenko, Krupenko: CHIP E3 ligase mediates proteasomal degradation of the proliferation regulatory protein ALDH1L1 during the transition of NIH3T3 fibroblasts from G0/G1 to S-phase. in PLoS ONE 2019
Genome-wide CRISPR screen followed by multiple siRNA screens in several pancreatic ductal adenocarcinoma (PDAC) cell models and in a noncancerous cell model validated PSMA6 as gene essential for cancer cells survival and showed that inhibition of this gene induces apoptosis and results in significantly reduced cell viability. Study provide compelling evidence that PSMA6 plays a significant oncogenic role.
PSMA6 is post-transcriptionally repressed by the microRNA-4490 in diabetic nephropathy.
Results suggest that proteasome subunit alpha type 6 (PSMA6) serves as an attractive target with a high therapeutic index for lung cancer.
The 5' untranslated region of PSMA6 gene contains a single nucleotide polymorphism -8 C/G associated with End-stage kidney disease and might be a protective factor for the disease.
These data indicate that hepatic expression of PSMA6, which is upregulated during viral hepatitis, likely depends on TLR3 activation and, that PSMA6 affects the expression of immunoregulatory ISG15, a proviral factor in the pathogenesis of hepatitis C virus infection.
Data indicate that proteasome subunit alpha 6 (PSMA6) direct contacts with proteasome subunit alpha 7 (PSMA7) tetradecamer.
Our results provide evidence on new T1DM-susceptible loci in the PSMA3, PSMA6 and PSMC6 proteasome genes and give a new insight into the T1DM pathogenesis
Evidence of a sex-specific association of PSMA6 genetic variants with subtypes of juvenile idiopathic arthritis.
The data show that LMP2 and PSMA6 gene polymorphism is not a risk factor of ischemic stroke in Ukrainian population.
The PSMA6 variant rs1048990 appears to affect susceptibility to ischaemic stroke in both caucasian and african american populations.
The G allele of PSMA6-8C/G polymorphism is a risk factor associated with increased coronary artery disease susceptibility. [Meat-analysis]
Investigation suggests that -8 C/G variant of PSMA6 gene may be associated with T2DM and diabetes-related metabolic traits in Chinese Dongxiang and Han populations.
PSMA6 polymorphisms were not associated with phenotype of coronary atherosclerosis.
the G-allele of the PSMA6-8C>G polymorphism is a possible survival prognosticator in multiple myeloma
A total of 1330 cases and 2554 controls from Japanese and Korean populations for PSMA6 genotypes were investigated, and no evidence of the association was obtained in both Japanese and Korean populations.
PSMA6 rs_1048990 polymorphism may contribute to MI susceptibility in type 2 diabetes.
common SNP (minor allele frequency of 0.35) in the proteasome subunit alpha type 6 gene (PSMA6) conferring risk of myocardial infarction in the Japanese population
The reported genotype in PSMA6 appears not to contribute appreciably to myocardial infarction, but may contribute slightly to atherosclerosis in the present study population.
2 SNPs at positions -110 & -8 from translation start, in the promoter region & 5'UTR of PSMA6 were analyzed; genotype -8CG was more frequent in type 2 diabetes patients & haplotype C-110/G-8, compared to C-110/C-8 was associated with higher risk of NIDDM
The GG genotype for rs1048990 was less frequent in the UK population than in the Japanese population, and was associated with an odds ratio for mi of 1.09 per G allele in a co-dominant genetic model and 1.32 in a recessive genetic model.
In this study a novel interaction between calcineurin and the 20S proteasome subunit PSMA6 that increased intracellular proteasomal activity was identified.
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits\; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. A pseudogene has been identified on the Y chromosome.
27 kDa prosomal protein
, macropain iota chain
, macropain subunit iota
, multicatalytic endopeptidase complex iota chain
, prosomal P27K protein
, proteasome iota chain
, proteasome subunit alpha type-6
, proteasome subunit iota
, proteasome alpha 6 subunit
, proteasome alpha 6a subunit
, proteasome (prosome, macropain) subunit, alpha type, 6
, 20S proteasome alpha1 subunit
, proteasome subunit alpha type 6