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In this study a novel interaction between calcineurin and the 20S proteasome (show PSMA5 Proteins) subunit PSMA6 that increased intracellular proteasomal activity was identified.
Results suggest that proteasome subunit alpha type 6 (PSMA6) serves as an attractive target with a high therapeutic index for lung cancer.
The 5' untranslated region of PSMA6 gene contains a single nucleotide polymorphism -8 C/G associated with End-stage kidney disease and might be a protective factor for the disease.
These data indicate that hepatic expression of PSMA6, which is upregulated during viral hepatitis, likely depends on TLR3 (show TLR3 Proteins) activation and, that PSMA6 affects the expression of immunoregulatory ISG15 (show ISG15 Proteins), a proviral factor in the pathogenesis of hepatitis C virus infection.
Data indicate that proteasome subunit alpha 6 (PSMA6) direct contacts with proteasome subunit alpha 7 (PSMA7 (show PSMA7 Proteins)) tetradecamer.
Our results provide evidence on new T1DM-susceptible loci in the PSMA3 (show PSMA3 Proteins), PSMA6 and PSMC6 (show PSMC6 Proteins) proteasome genes and give a new insight into the T1DM pathogenesis
Evidence of a sex-specific association of PSMA6 genetic variants with subtypes of juvenile idiopathic arthritis.
The data show that LMP2 (show PSMB9 Proteins) and PSMA6 gene polymorphism is not a risk factor of ischemic stroke in Ukrainian population.
The PSMA6 variant rs1048990 appears to affect susceptibility to ischaemic stroke in both caucasian and african american populations.
The G allele of PSMA6-8C/G polymorphism is a risk factor associated with increased coronary artery disease susceptibility. [Meat-analysis]
Investigation suggests that -8 C/G variant of PSMA6 gene may be associated with T2DM and diabetes-related metabolic traits in Chinese Dongxiang and Han populations.
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits\; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. A pseudogene has been identified on the Y chromosome.
macropain iota chain
, multicatalytic endopeptidase complex iota chain
, proteasome iota chain
, proteasome subunit alpha type-6
, proteasome alpha 6 subunit
, 27 kDa prosomal protein
, macropain subunit iota
, prosomal P27K protein
, proteasome subunit iota