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The knockout of beta2i ameliorates DOCA/salt-induced cardiac fibrosis and inflammation, and may be a novel potential therapeutic target for hypertensive heart diseases.
LMP7 (show PSMB8 Proteins) and MECL1 regulate cytokine expression, suggesting this system represents a novel mechanism for the regulation of cytokines and cytokine signaling
Findings strongly support the concept that LMP7 (show PSMB8 Proteins)/MECL-1 proteasomes subunits actively function to regulate LPS (show TLR4 Proteins)-induced NO production by affecting the TRIF/TRAM (show TICAM2 Proteins) pathway.
phenotype of hyperproliferation of T cells lacking both MECL-1 and LMP7 implicates a specific role for immunoproteasomes in T cell proliferation that is not obviously connected to MHC class I Ag processing
An in vivo function of MECL-1 codetermines the T cell repertoire for an antiviral cytotoxic T lymphocyte (CTL) response specific for lymphocytic choriomeningitis virus that is altered in MECL1-deficient mice.
The findings indicate that MECL-1 influences the homeostatic equilibrium between T-cell subsets, not through indirect extracellular signals, such as MHC-I expression or the cytokine milieu, but through direct effects on T-cell-intrinsic processes.
designed siRNAs that efficiently silence LMP2 (show PSMB9 Proteins), LMP7 (show PSMB8 Proteins) and MECL-1 gene expression.
LMP10 nuclear expression in the Human Papillomavirus (HPV)-positive group and LMP10 cytoplasmic expression in the HPV-negative group of patients correlated to better clinical outcome.
Data indicate that treatment-emergent resistance to single-agent bortezomib was independent of variants in the proteasome genes PSMB1 (show PSMB1 Proteins), PSMB5 (show PSMB5 Proteins), PSMB6 (show PSMB6 Proteins), PSMB8 (show PSMB8 Proteins), PSMB9 (show PSMB9 Proteins), and PSMB10.
Adenovirus E1A (show BCKDHA Proteins) causes down-regulation of MECL1 expression
Impaired expression of proteasome subunits is involved in the loss of HLA class I (show MICA Proteins) expression in human colon cancer cells.
Multicatalytic endopeptidase complex subunit is involved in antigen presentation and is an important candidate gene for initial exploration of relationships between antigen processing genes and disease resistance.
These data reveal a novel "feed-forward" mechanism induced by NF-kappaB (show NFKB1 Proteins) which ensures that acutely synthesized IRF-1 (show IRF1 Proteins) operates in concert with NF-kappaB (show NFKB1 Proteins) to amplify the immunoproteasome and antigen-processing functions of CD40 (show CD40 Proteins).
The porcine PSMB10 was mapped by somatic cell hybrid panel and radiation hybrid mapping on SSC6p14-p15 (show CDKN2B Proteins).
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits\; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. Proteolytic processing is required to generate a mature subunit. Expression of this gene is induced by gamma interferon, and this gene product replaces catalytic subunit 2 (proteasome beta 7 subunit) in the immunoproteasome.
low molecular mass protein 10
, macropain subunit MECl-1
, multicatalytic endopeptidase complex subunit MECl-1
, prosome Mecl1
, proteasome (prosomome, macropain) subunit, beta type 10
, proteasome MECl-1
, proteasome subunit MECL1
, proteasome subunit beta type-10
, proteasome subunit beta-2i
, proteasome catalytic subunit 2i
, proteasome subunit beta 7i
, proteasome beta 10 subunit