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Browse our Proteasome (Prosome, Macropain) Subunit, beta Type, 4 Proteins (PSMB4)

Full name:: Proteasome (Prosome, Macropain) Subunit, beta Type, 4 Proteins (PSMB4)

On www.antibodies-online.com are 11 Proteasome (Prosome, Macropain) Subunit, beta Type, 4 (PSMB4) Proteins from 5 different suppliers available. Additionally we are shipping Proteasome (Prosome, Macropain) Subunit, beta Type, 4 Antibodies (117) and Proteasome (Prosome, Macropain) Subunit, beta Type, 4 Kits (12) and many more products for this protein. A total of 148 Proteasome (Prosome, Macropain) Subunit, beta Type, 4 products are currently listed.

Synonyms:: An18g06680, HN3, HsN3, im:6909492, PROS-26, Pros-27, PROS26, PSMB4, zgc:110330

list all proteins	Gene Name	GeneID	UniProt
	PSMB4	19172	P99026
	PSMB4	58854	P34067
	PSMB4	5692	P28070
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Human Proteasome (Prosome, Macropain) Subunit, beta Type, 4 (PSMB4) interaction partners

High PSMB4 expression is associated with breast cancer.
PSMB4 knockdown decreased the expression levels of MMP2, MMP9 and cathepsin B and decreased proliferation, migration and invasion abilities in human GBM cells.
We further identified miR-148b as a negative regulator of proteasome beta-4 subunit. Enforced expression of miR-148b resulted in vitro growth inhibition of melanoma cells, whereas this inhibition was further abolished by enforced expression of proteasome beta-4 subunit
Our findings implied that PSMB4 is involved in the progression of EOC (epithelial ovarian cancer) and could serve as potential therapeutical target of EOC. These data suggested that PSMB4 may promote cell proliferation via the NF-kappaB-target gene in EOC (epithelial ovarian cancer)
Taken together, our results demonstrated that PSMB4 regulated MM cell growth in part by activating NF-kappaB-miR-21 signaling, which may represent promising targets for novel specific therapies.
Data indicate that recruitment of proteasomes into mutant huntingtin (mHTT) protein initiated inclusion bodies (IBs) was observed when the PSMB4-GFP was co-expressed with mHTT.
proteasome subunit beta type 4 (PSMB4), the beta7 subunit of the 20S core complex, was identified as a direct binding partner of CRBN.
While 26 proteasome dysfunction is observed in Parkinson's disease (PD), diverse mutations in the parkin gene are linked to early-onset autosomal-recessive forms of familial PD.

Proteasome (Prosome, Macropain) Subunit, beta Type, 4 (PSMB4) Protein Profile

Protein Summary

The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits\; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit.

Alternative names and synonyms associated with Proteasome (Prosome, Macropain) Subunit, beta Type, 4 (PSMB4)

proteasome subunit beta type-4 (ANI_1_890164)
proteasome subunit beta 4 (PSMB4)
proteasome subunit beta 4 (psmb4)
proteasome (prosome, macropain) subunit, beta type 4 (Psmb4)
proteasome subunit beta 4 (Psmb4)
proteasome subunit beta 4 L homeolog (psmb4.L)

An18g06680 protein
HN3 protein
HsN3 protein
im:6909492 protein
PROS-26 protein
Pros-27 protein
PROS26 protein
PSMB4 protein
zgc:110330 protein

Protein level used designations for PSMB4

proteasome (prosome, macropain) subunit, beta type, 4 , proteasome beta 4 subunit , low molecular mass protein 3 , macropain beta chain , multicatalytic endopeptidase complex beta chain , proteasome beta chain , proteasome chain 3 , proteasome subunit beta type-4 , RN3 , proteasome beta subunit , 26 kDa prosomal protein , hsBPROS26 , proteasome subunit HsN3 , proteasome subunit, beta type, 4

GENE ID	SPECIES
4990236	Aspergillus niger CBS 513.88
429986	Gallus gallus
457293	Pan troglodytes
496603	Xenopus (Silurana) tropicalis
19172	Mus musculus
58854	Rattus norvegicus
380584	Xenopus laevis
5692	Homo sapiens
475848	Canis lupus familiaris
100153923	Sus scrofa
506203	Bos taurus
100328673	Oryctolagus cuniculus
550499	Danio rerio
101116188	Ovis aries

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