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PSMB4 knockdown decreased the expression levels of MMP2 (show MMP2 Proteins), MMP9 (show MMP9 Proteins) and cathepsin B (show CTSB Proteins) and decreased proliferation, migration and invasion abilities in human GBM cells.
We further identified miR (show MLXIP Proteins)-148b as a negative regulator of proteasome beta-4 subunit. Enforced expression of miR (show MLXIP Proteins)-148b resulted in vitro growth inhibition of melanoma cells, whereas this inhibition was further abolished by enforced expression of proteasome beta-4 subunit
Our findings implied that PSMB4 is involved in the progression of EOC (epithelial ovarian cancer) and could serve as potential therapeutical target of EOC. These data suggested that PSMB4 may promote cell proliferation via the NF-kappaB (show NFKB1 Proteins)-target gene in EOC (epithelial ovarian cancer)
Taken together, our results demonstrated that PSMB4 regulated MM cell growth in part by activating NF-kappaB (show NFKB1 Proteins)-miR (show MLXIP Proteins)-21 signaling, which may represent promising targets for novel specific therapies.
Data indicate that recruitment of proteasomes into mutant huntingtin (show HTT Proteins) (mHTT) protein initiated inclusion bodies (IBs) was observed when the PSMB4-GFP was co-expressed with mHTT.
proteasome subunit beta type 4 (PSMB4), the beta7 subunit of the 20S core complex, was identified as a direct binding partner of CRBN (show CRBN Proteins).
While 26 proteasome dysfunction is observed in Parkinson's disease (PD), diverse mutations in the parkin (show PARK2 Proteins) gene are linked to early-onset autosomal-recessive forms of familial PD.
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits\; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit.
proteasome (prosome, macropain) subunit, beta type, 4
, proteasome beta 4 subunit
, low molecular mass protein 3
, macropain beta chain
, multicatalytic endopeptidase complex beta chain
, proteasome beta chain
, proteasome chain 3
, proteasome subunit beta type-4
, proteasome beta subunit
, 26 kDa prosomal protein
, proteasome subunit HsN3
, proteasome subunit, beta type, 4