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Human Polyclonal PSMB5 Primary Antibody for WB - ABIN519378
Grimm, Ott, Hörlacher, Weber, Höhn, Grune: Advanced-glycation-end-product-induced formation of immunoproteasomes: involvement of RAGE and Jak2/STAT1. in The Biochemical journal 2012
Cow (Bovine) Polyclonal PSMB5 Primary Antibody for WB - ABIN2786720
Ewing, Chu, Elisma, Li, Taylor, Climie, McBroom-Cerajewski, Robinson, OConnor, Li, Taylor, Dharsee, Ho, Heilbut, Moore, Zhang, Ornatsky, Bukhman, Ethier, Sheng, Vasilescu, Abu-Farha, Lambert, Duewel et al.: Large-scale mapping of human protein-protein interactions by mass spectrometry. ... in Molecular systems biology 2007
The P2Y2R enhances Ubiquitin-Proteasome System activity by increasing the subunits expression beta 5 and beta 1.
The role of the ubiquitin-proteasome system in pressure overloaded hearts andheart failure.
Probeta5 predominantly promotes integration into LMP2/MECL-1-containing precursors in IFNgamma-stimulated, LMP7-deficient cells and infected LMP7-deficient mice.
Data demonstrate that TNF-alpha expression is primarily dependent on both the chymotrypsin-and the trypsin-like activities of X, Y, Z subunits (PSMB5, PSMB6, PSMB7) of the proteasome.
PSMB5 mutations are associated with multiple myeloma.
PSMB5 knockdown could increase the expression of pro-apoptosis gene Bax and cleaved caspase-3
Our results suggest a potential role for PSMB5 as a biomarker and therapeutic target for Triple-negative breast cancer
Results identified PSMB5 Q62P mutation to underlie bortezomib resistance in Down-syndrome-associated acute myeloid leukemia cells.
We also discovered and replicated three genome-wide significant variants in previously unreported loci for RDW (SLC12A2 rs17764730, PSMB5 rs941718), and hematocrit (PROX1 rs3754140) and an upstream anti-sense long-noncoding RNA, LINC01184, as the likely causal variant
Data indicate that proteasomal subunit X PSMB5 is a target of signal transducer and activator of transcription 3 (STAT3).
Nuclear MB1 expression was an independent predictor of worse survival in ovarian cancer.
critical role of PSMB5 in 20S proteasome-mediated protection against replicative senescence, pointing to a possible strategy for maintaining the integrity of culture-expanded bone marrow stromal cells by manipulating the expression of PSMB5
The expression of proteasome beta5 decreases markedly in human atherosclerotic plaques.
Data indicate that treatment-emergent resistance to single-agent bortezomib was independent of variants in the proteasome genes PSMB1, PSMB5, PSMB6, PSMB8, PSMB9, and PSMB10.
Letter/Case Reports: proteasome subunit beta5t is expressed in cervical ectopic thymoma.
PSMB5 overexpression is associated with Bortezomib resistance in myeloma.
No mutations or differences in PSMB5 mRNA expression were seen before bortezomib treatment in 3 multiple myeloma patients, but after treatment, 1 patient showed PSMB5 upregulation associated with bortezomib resistance.
CDK5 regulation of proteasome subunit PSMB5 was identified as a probable route to antineoplastic drug sensitization.
Expression of mutated PSMB5 was associated with the prevention of the accumulation of unfolded proteins
interaction of TAP1 and TAP2 and P-glycoprotein with proteasome subunits beta-5 and beta-5i suggest direct targeting of antigenic peptides to the ER via a TAP-proteasome association and a possible role for P-glycoprotein
Proteasome activity can be genetically "upregulated" in lens cells by overexpression of beta5 catalytic subunit. Resulting increase in proteasome activity leads to decrease in oxidized proteins and enhanced cell survival following oxidative stress.
G322A mutation of the PSMB5 gene is a novel mechanism for bortezomib resistance.
nonsynonymous coding single nucleotide polymorphismsin the proteasome beta 5 subunit gene did not show significant effects on proteasome activity, but SNPs did influence transcription
Overexpression of PSMB5 is an important mechanism for bortezomib resistance in Jurkat cell lines.
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits\; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit in the proteasome. This catalytic subunit is not present in the immunoproteasome and is replaced by catalytic subunit 3i (proteasome beta 8 subunit). Multiple transcript variants encoding different isoforms have been found for this gene.
proteasome subunit beta type 5
, proteasome subunit beta type-5
, proteasome (prosome, macropain) subunit, beta type, 5
, macropain epsilon chain
, multicatalytic endopeptidase complex epsilon chain
, proteasome beta type subunit 5
, proteasome chain 6
, proteasome epsilon chain
, proteasome subunit X
, proteasome beta 5 subunit
, PSX large multifunctional protease X
, proteasome catalytic subunit 3
, proteasome subunit MB1
, proteasome subunit, beta type, 5
, macropain chain 1
, multicatalytic endopeptidase complex chain 1
, proteasome C1 subunit
, proteasome chain 1
, proteasome subunit C1