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Data demonstrate that TNF-alpha (show TNF Proteins) expression is primarily dependent on both the chymotrypsin-and the trypsin-like activities of X, Y, Z subunits (PSMB5 (show PSMB5 Proteins), PSMB6 (show PSMB6 Proteins), PSMB7) of the proteasome.
high PSMB7 expression is associated with anthracycline resistance in breast cancer.
Low protein Z (show PROZ Proteins) levels but not protein Z (show PROZ Proteins) gene G79A polymorphism are a risk factor for ischemic stroke.
A previously unreported sporadic missense mutation within exon 8 is described in a patient with very low protein Z (show PROZ Proteins) levels.
PSB7, PRDX1 (show PRDX1 Proteins), and SRP9 (show SRP9 Proteins) up-regulation as candidate biomarkers of colon cancer is discovered
ZPI (show SERPINA10 Proteins) functions like other serpins to regulate the activity of FXa (show F10 Proteins) but in a manner uniquely dependent on protein Z (show PROZ Proteins), procoagulant membranes, and pH
we have identified and characterized a new phosphorylated isoform of the human 20S proteasome (show PSMA5 Proteins) b7 subunit and showed its differential expression in tumor vs. normal cell lines
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits\; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. The encoded protein is a member of the proteasome B-type family, also known as the T1B family, and is a 20S core beta subunit in the proteasome. Expression of this catalytic subunit is downregulated by gamma interferon, and proteolytic processing is required to generate a mature subunit. A pseudogene of this gene is located on the long arm of chromosome 14.
proteasome subunit beta type 7
, proteasome subunit beta type-7
, proteasome beta 7 subunit
, proteasome subunit beta type-7 proprotein
, proteasome (prosome, macropain) subunit, beta type, 7
, proteasome z subunit-like protein
, macropain chain Z
, multicatalytic endopeptidase complex chain Z
, proteasome subunit Z
, proteasome catalytic subunit 2
, proteasome subunit alpha
, beta-type proteasome 7 subunit