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JAK1 (show JAK1 Proteins) mutations are highly frequent in microsatellite unstable endometrial cancer, not associated with survival, but are associated with impaired upregulation of LMP7 and HLA class I (show MICA Proteins) and may therefore facilitate immune escape
Upregulation of proteasome subunit beta type 8 PSMB8 and PDZ binding kinase PBK (show PBK Proteins) was confirmed by real-time reverse transcription-PCR analysis.
This is the first study to report that the heterozygous LMP2 (show PSMB9 Proteins) R/C and homozygous C/C genotypes increase susceptibility to ESCC in the Kazakh population and that the heterozygous LMP7 Q/K genotype decreases susceptibility to ESCC in this population
PSMB8 rs2071464 was associated with generalized and active vitiligo (show MITF Proteins) from Gujarat whereas TAP1 (show TAP1 Proteins) rs1135216 showed no association. The down-regulation of PSMB8 in patients with risk genotype 'CC' advocates the vital role of PSMB8 in the autoimmune basis of vitiligo (show MITF Proteins).
results suggest that PSMB8 is a predictive marker of preoperative radiosensitivity in locally advanced rectal cancer patients.
Data show that tight junction protein 1 (TJP1 (show TJP1 Proteins)) suppressed expression of the catalytically proteasome subunits LMP7 and LMP2 (show PSMB9 Proteins), decreased proteasome activity, and enhanced proteasome inhibitor sensitivity in vitro and in vivo through suppression of EGFR (show EGFR Proteins)/JAK1 (show JAK1 Proteins)/STAT3 (show STAT3 Proteins) signaling.
there was no significant difference with respect to the genotypic frequencies of the SNPs in PSMB8, TAP1, and TAP2 loci in Parkinson's disease patients
We described a Brazilian patient with CANDLE syndrome possessing a novel mutation in the PSMB8 gene.
designed siRNAs that efficiently silence LMP2 (show PSMB9 Proteins), LMP7 and MECL-1 (show PSMB10 Proteins) gene expression.
demonstrated that patients with the LMP-7 CA/AA genotypes were more likely to have advanced fibrosis scores than those bearing the CC genotype
The regulation of miR (show MLXIP Proteins)-451 via the LMP7/NF-kappaB (show NFKB1 Proteins) central inflammatory pathway during progression of DN.
The authors found that selective inhibition of LMP7 had neither an influence on allograft survival in an major histocompatibility complex-mismatch model nor in a multiple minor mismatch skin transplantation model.
LMP7 deficiency decreased inflammatory responses such as macrophage infiltration and chemokine (show CCL1 Proteins) expression while it increased serum adiponection levels.
these data support that LMP7 inhibition in the context of BMT modulates allogeneic responses by decreasing endogenous miHA (show XIAP Proteins) presentation and that the consequential reduction in allogeneic stimulation and cytokine production reduces GVHD development.
PSMB8, ALDH1A1 (show ALDH1A1 Proteins), and HSPA4 (show HSPA4 Proteins) were identified to be located in ovarian tissues, to regulate 12 cellular pathways, and demonstrate age-dependent dynamic changes in expression profiling.
Overexpression of the immunoproteasome LMP7 subunit in antigen-presenting cells due to lipopolysaccharide exposure as well as LMP7 expression in peripheral cells, are required for CD8 (show CD8A Proteins)+ T-cell auto-reactivity.
Data show that knockdown of i-proteasome catalytic subunit PSMB9 (show PSMB9 Proteins) by short hairpin RNA (shRNA) decreased the expression of both PSMB9 (show PSMB9 Proteins) and PSMB8 without affecting other catalytic subunits of the proteasome.
we present novel evidence for the requirement of the beta5i immunosubunit to generate a strong Th2 response during OVA- but not HDM (show HDAC3 Proteins)-induced acute asthma.
Red blood cells of LMP7-deficient mice were more likely to deform in response to infection with malaria parasites, presumably resulting in higher susceptibility to phagocytosis and in the partial resistance to malaria.
Deletion or inhibition of LMP7 suppresses generation of T helper (Th)17 cells but promotes regulatory T cell (Treg) development.
These results suggest LMP2 (show PSMB9 Proteins)/LMP7 gene should be regarded as molecular marker to estimate animal's immune status for their effects on hematological traits.
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits\; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 3 (proteasome beta 5 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit. Two alternative transcripts encoding two isoforms have been identified\; both isoforms are processed to yield the same mature subunit.
large multifunctional peptidase 7
, low molecular mass protein 7
, low molecular weight protein 7
, macropain subunit C13
, multicatalytic endopeptidase complex subunit C13
, protease component C13
, proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)
, proteasome catalytic subunit 3i
, proteasome component C13
, proteasome subunit Y2
, proteasome subunit beta 5i
, proteasome subunit beta type-8
, proteasome-related gene 7
, really interesting new gene 10 protein
, MHC class II DO beta
, proteasome subunit beta-5i
, proteasome (prosome, macropain) subunit, beta type, 8
, large multifunctional protease 7
, proteosome (prosome, macropain) subunit, beta type 8
, MC13 (LMP7)
, proteasome subunit MC13
, proteosome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)
, proteosome beta 8 subunit
, low molecular mass polypeptide 7
, proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)
, proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional protease 7)
, proteasome beta 8 subunit
, proteasome subunit LMP7
, proteasome subunit, beta type 8