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Study identified PSMB8 as a specific biomarker for mucinous ovarian carcinoma (MuOC) as it is strongly expressed in MuOC but not in the serous type samples.
PSMB8 is closely associated with migration, proliferation, and apoptosis of glioma cells.
The present study illustrated that the carriage of LMP7 rs2071543-AA and TAP2 rs1800454-AA had a negative effect on treatment response to pegIFN-alpha/RBV among genotype 1 patient with chronic hepatitis C (CHC) in a Chinese Han population
JAK1 mutations are highly frequent in microsatellite unstable endometrial cancer, not associated with survival, but are associated with impaired upregulation of LMP7 and HLA class I and may therefore facilitate immune escape
Upregulation of proteasome subunit beta type 8 PSMB8 and PDZ binding kinase PBK was confirmed by real-time reverse transcription-PCR analysis.
This is the first study to report that the heterozygous LMP2 R/C and homozygous C/C genotypes increase susceptibility to ESCC in the Kazakh population and that the heterozygous LMP7 Q/K genotype decreases susceptibility to ESCC in this population
PSMB8 rs2071464 was associated with generalized and active vitiligo from Gujarat whereas TAP1 rs1135216 showed no association. The down-regulation of PSMB8 in patients with risk genotype 'CC' advocates the vital role of PSMB8 in the autoimmune basis of vitiligo.
results suggest that PSMB8 is a predictive marker of preoperative radiosensitivity in locally advanced rectal cancer patients.
Data show that tight junction protein 1 (TJP1) suppressed expression of the catalytically proteasome subunits LMP7 and LMP2, decreased proteasome activity, and enhanced proteasome inhibitor sensitivity in vitro and in vivo through suppression of EGFR/JAK1/STAT3 signaling.
there was no significant difference with respect to the genotypic frequencies of the SNPs in PSMB8, TAP1, and TAP2 loci in Parkinson's disease patients
We described a Brazilian patient with CANDLE syndrome possessing a novel mutation in the PSMB8 gene.
designed siRNAs that efficiently silence LMP2, LMP7 and MECL-1 gene expression.
Proteasome beta5i Subunit Deficiency Affects Opsonin Synthesis and Aggravates Pneumococcal Pneumonia.
demonstrated that patients with the LMP-7 CA/AA genotypes were more likely to have advanced fibrosis scores than those bearing the CC genotype
lupus nephritis showed up-regulation of the immunoproteasome subunit LMP7 in tubular epithelial cells associated with type I interferon signature.
Comparison with reference profiles of sorted immune cells and healthy muscle confirmed upregulation of PSMB8 and -9 in myositis biopsies beyond infiltration related changes.
The LMP7 gene promoter methylation and protein downregulation were correlated at high extent in Kazakh's ESCC patients, and may explain the epigenetic regulation on gene expression.
In patients with primary Sjogren's syndrome, the expression of LMP7 (but not LMP2) is up-regulated in the labial gland.
Data indicate that treatment-emergent resistance to single-agent bortezomib was independent of variants in the proteasome genes PSMB1, PSMB5, PSMB6, PSMB8, PSMB9, and PSMB10.
The MAGE-C(2336-344) antigenic peptide is produced by the immunoproteasome and intermediate proteasome beta1i-beta5i, but not by the standard proteasome nor intermediate proteasome beta5i.
Employing the lymphocytic choriomeningitis virus (LCMV) infection model, we showed that the immunoproteasome subunit LMP7 was absolutely required for the generation of LCMV GP118-125 -specific T cells although the class I mediated presentation of GP118-125 was not dependent on LMP7.
Proteostatic responses included a significant increase in the levels of Lmp7, a component of the immunoproteasome. Increased Lmp7 levels and activity were also quantified in postmortem human brains with PD and dementia with Lewy bodies.
Psmb8 directly regulates the differentiation of preadipocytes and additionally the differentiation of preadipocytes to mature adipocytes. Psmb8(-/-) mice had slower weight gain, reduced adipose tissue volume, less preadipocyte precursors and preadipocytes, and smaller size of mature adipocytes compared with controls. Loss of Psmb8 activity in 3T3-L1 cells disturbed the differentiation to mature adipocytes.
The regulation of miR-451 via the LMP7/NF-kappaB central inflammatory pathway during progression of DN.
The authors found that selective inhibition of LMP7 had neither an influence on allograft survival in an major histocompatibility complex-mismatch model nor in a multiple minor mismatch skin transplantation model.
LMP7 deficiency decreased inflammatory responses such as macrophage infiltration and chemokine expression while it increased serum adiponection levels.
these data support that LMP7 inhibition in the context of BMT modulates allogeneic responses by decreasing endogenous miHA presentation and that the consequential reduction in allogeneic stimulation and cytokine production reduces GVHD development.
genetic polymorphism is associated with ovarian cancer and metastasis
PSMB8, ALDH1A1, and HSPA4 were identified to be located in ovarian tissues, to regulate 12 cellular pathways, and demonstrate age-dependent dynamic changes in expression profiling.
Overexpression of the immunoproteasome LMP7 subunit in antigen-presenting cells due to lipopolysaccharide exposure as well as LMP7 expression in peripheral cells, are required for CD8+ T-cell auto-reactivity.
Data show that knockdown of i-proteasome catalytic subunit PSMB9 by short hairpin RNA (shRNA) decreased the expression of both PSMB9 and PSMB8 without affecting other catalytic subunits of the proteasome.
we present novel evidence for the requirement of the beta5i immunosubunit to generate a strong Th2 response during OVA- but not HDM-induced acute asthma.
Red blood cells of LMP7-deficient mice were more likely to deform in response to infection with malaria parasites, presumably resulting in higher susceptibility to phagocytosis and in the partial resistance to malaria.
Deletion or inhibition of LMP7 suppresses generation of T helper (Th)17 cells but promotes regulatory T cell (Treg) development.
Probeta5 predominantly promotes integration into LMP2/MECL-1-containing precursors in IFNgamma-stimulated, LMP7-deficient cells and infected LMP7-deficient mice.
LMP7 and MECL1 regulate cytokine expression, suggesting this system represents a novel mechanism for the regulation of cytokines and cytokine signaling
We show that mice deficient for the immunosubunits beta5i/low molecular mass polypeptide (LMP7) and beta2i/multicatalytic endopeptidase complex-like-1 develop early-stage multiorgan autoimmunity following irradiation and bone marrow transplantation
Findings strongly support the concept that LMP7/MECL-1 proteasomes subunits actively function to regulate LPS-induced NO production by affecting the TRIF/TRAM pathway.
A dominant role for the immunoproteasome in CD8+ T cell responses to murine cytomegalovirus.
The presence of immuno subunits in nonimmune tissues such as lens suggests that the immunoproteasome may also have nonimmune functions, such as that in lens differentiation.
These results suggest LMP2/LMP7 gene should be regarded as molecular marker to estimate animal's immune status for their effects on hematological traits.
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits\; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 3 (proteasome beta 5 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit. Two alternative transcripts encoding two isoforms have been identified\; both isoforms are processed to yield the same mature subunit.
large multifunctional peptidase 7
, low molecular mass protein 7
, low molecular weight protein 7
, macropain subunit C13
, multicatalytic endopeptidase complex subunit C13
, protease component C13
, proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)
, proteasome catalytic subunit 3i
, proteasome component C13
, proteasome subunit Y2
, proteasome subunit beta 5i
, proteasome subunit beta type-8
, proteasome-related gene 7
, really interesting new gene 10 protein
, MHC class II DO beta
, proteasome subunit beta-5i
, proteasome (prosome, macropain) subunit, beta type, 8
, large multifunctional protease 7
, proteosome (prosome, macropain) subunit, beta type 8
, MC13 (LMP7)
, proteasome subunit MC13
, proteosome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)
, proteosome beta 8 subunit
, low molecular mass polypeptide 7
, proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)
, proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional protease 7)
, proteasome beta 8 subunit
, proteasome subunit LMP7
, proteasome subunit, beta type 8