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In Psmc1(+/-)primary mouse embryonic fibroblasts we found decreased PSMC1 protein expression, altered assembly of the 26S proteasome (show Psmd4 Proteins) and G2/M cell cycle arrest.
Caspase-3 (show CASP3 Proteins) cleaves specific 19 S proteasome subunits in skeletal muscle stimulating proteasome activity
P26s4 Associates with the C-Terminal Region of TOPORS (show TOPORS Proteins).
Our results suggest that there is no association between variations or haplotypes in the PSMC1 gene and Parkinson's disease
Hepatocytes dying because of inhibition of proteasome function produce massive quantities of the proinflammatory chemokine (show CCL1 Proteins) IL-8 (show IL8 Proteins), possibly resulting in neutrophil infiltration, increased inflammation, and liver injury.
Psmc1 conditional knock-out mice demonstrate that 26S proteasomal dysfunction is sufficient to trigger neurodegenerative disease.
Thus, the results of our study suggest that the H-FABP (show FABP3 Proteins) and PSMC1 gene polymorphisms could be used as genetic markers in marker-assisted selection for improving Qinchuan beef cattle
reveal critical roles of COOH termini of Rpt subunits of PA700 in the assembly and activation of eukaryotic 26 S proteasome[PA700 proteasome activator ]
data show that animals with AA genotype have a lower food intake, grow faster, are longer in the body & have less backfat & bigger loin muscle; PSMC1 gene was expressed mainly in lung, testis, and spleen; mapped PSMC1 gene on BTA10
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits\; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit and a 20S core alpha subunit interact specifically with the hepatitis B virus X protein, a protein critical to viral replication. This subunit also interacts with the adenovirus E1A protein and this interaction alters the activity of the proteasome. Finally, this subunit interacts with ataxin-7, suggesting a role for the proteasome in the development of spinocerebellar ataxia type 7, a progressive neurodegenerative disorder.
26S protease regulatory subunit 4
, 26S proteasome AAA-ATPase subunit RPT2
, proteasome 26S subunit ATPase 1
, proteasome 26S ATPase subunit 1
, proteasome 26S subunit, ATPase, 1
, peptidase (prosome, macropain) 26S subunit, ATPase 1
, protease (prosome, macropain) 26S subunit, ATPase 1
, 26S ATPase complex subunit 4