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Our results provide evidence on new T1DM-susceptible loci in the PSMA3, PSMA6 and PSMC6 proteasome genes and give a new insight into the T1DM pathogenesis
Evidence of a sex-specific association of PSMC6 genetic variants with subtypes of juvenile idiopathic arthritis.
Advanced oxidation protein products down-regulate the expression of calcium transport channels through p44/42 MAPK signaling mechanisms in the small intestinal epithelium.
N protein of SARS Coronavirus interacts with the host cell proteasome subunit p42.
Data indicte that knockdown of PA700/S10B of the 26S proteasome blocked the degradation of the vascular protective molecules and ablated endothelial dysfunction.
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits\; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. Pseudogenes have been identified on chromosomes 8 and 12.
26S protease regulatory subunit S10B
, 26S protease regulatory subunit S10b
, 26S proteasome subunit ATPase 6
, proteasome (prosome, macropain) 26S subunit, ATPase, 6-like
, similar to proteasome 26S ATPase subunit 6
, proteasome (prosome, macropain) 26S subunit, ATPase, 6
, proteasome 26S ATPase subunit 6
, 26S protease regulatory subunit S10B-like
, 26S protease regulatory subunit 10B
, 26S proteasome AAA-ATPase subunit RPT4
, conserved ATPase domain protein 44
, proteasome 26S subunit ATPase 6
, proteasome subunit p42