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Gankyrin expression promotes spontaneous cancer and non-cancerous liver diseases. Gankyrin accelerates liver steatosis, cholangitis, fibrosis, and hepatocarcinogenesis with persistent damage and proliferation in hepatocytes.
This study is the first to report gankyrin as a potential link between microRNAs and liver steatosis in zebrafish.
the results demonstrated that the lentivirus-mediated shRNA vector-based RNAi expression system is an efficient method to silence PSMD10 gene expression in the MM RPMI-8226 cell line. It may provide a basis to study the role of PSMD10 in tumor cells, and may be a reliable gene therapy strategy in the clinic
Gankyrin sustains PI3K (show PIK3CA Proteins)/GSK-3beta/beta-catenin (show CTNNB1 Proteins) signal activation and promotes an aggressive colorectal cancer phenotype and disease progression.
PSMD10/gankyrin has a role in inducing autophagy to promote tumor progression through cytoplasmic interaction with ATG7 (show ATG7 Proteins) and nuclear transactivation of ATG7 (show ATG7 Proteins) expression
we conclude that FXR (show NR1H4 Proteins)-Gank-TSPs-Stem cells pathway is a key determinant of liver cancer in animal models and in pediatric liver cancer. Our data provide a strong basis for development of FXR (show NR1H4 Proteins)-Gank-based therapy for treatment of patients with hepatoblastoma
p28 assists the proteolytic core particle to select a specific conformation of the ATPase ring for regulatory particle engagement and is released in a shoehorn-like fashion in the last step of the chaperone-mediated proteasome assembly.
gankyrin regulates HIF-1alpha (show HIF1A Proteins) protein stability and cyclin D1 (show CCND1 Proteins) expression, ultimately mediating FSH (show BRD2 Proteins)-driven ovarian cancer cell proliferation
The positive feedback regulation involving gankyrin and Nrf2 (show GABPA Proteins) modulates a series of antioxidant enzymes, thereby lowering intracellular ROS (show ROS1 Proteins) and conferring a steadier intracellular environment, which prevents mitochondrial damage and cell death induced by excessive oxidative stress.
Gankyrin enhanced gastric cancer cell proliferation by regulating cell cycle-related proteins and by activating PI3K (show PIK3CA Proteins)/AKT (show AKT1 Proteins) signaling pathway. Gankyrin played an important role in gastric carcinogenesis and could be a potential effective therapeutic target for enhancing chemosensitivity to 5-fluorouracil and cisplatin.
gankyrin is an oncoprotein that can be modified by small molecules in tumor cell lines
Gankyrin overexpression activates mTORC1 signaling and accelerating TSC2 degradation in colorectal tumor cells.
the present study clarified, at least partly, mechanisms of vascular tumorigenesis, and suggests that gankyrin might play a physiological role in hypoxic responses besides its roles as an oncoprotein.
FXR (show NR1H4 Proteins) prevents liver cancer by inhibiting the gankyrin promoter via C/EBPbeta (show CEBPB Proteins)-HDAC1 (show HDAC1 Proteins) complexes, leading to subsequent protection of tumor suppressor proteins from degradation.
Gankyrin is a key regulator of Ras-mediated activation of Akt through inhibition of the downstream RhoA/ROCK pathway and thus plays an essential role in Ras-induced tumorigenesis.
Findings suggest that retinoblastoma protein degradation in Lmna (show LMNA Proteins)-/- cells occurs by gankyrin and MDM2 (show MDM2 Proteins)-independent mechanisms.
Gankyrin oncoprotein has a role in progression of esophageal squamous cell carcinoma
This gene encodes a subunit of the PA700/19S complex, which is the regulatory component of the 26S proteasome. The 26S proteosome complex is required for ubiquitin-dependent protein degradation. This protein is a non-ATPase subunit that may be involved in protein-protein interactions. Aberrant expression of this gene may paly a role in tumorigenesis. Two transcripts encoding different isoforms have been described. Pseudogenes have been identified on chromosomes 3 and 20.
26S proteasome non-ATPase regulatory subunit 10
, proteasome 26S subunit, non-ATPase, 10
, 26S proteasome regulatory subunit p28
, ankyrin repeat protein
, hepatocellular carcinoma-associated protein p28-II
, proteasome subunit p28
, proteosome (prosome, macropain) 26S subunit, non-ATPase, 10
, proteosome subunit p28
, proteasome 26S non-ATPase subunit 10