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Data show that activated PKA phosphorylates the 19S subunit, Rpn6/PSMD11 (regulatory particle non-ATPase 6/proteasome subunit D11) at Ser14.
human embryonic stem cells (hESCs) exhibit high proteasome activity that is correlated with increased levels of the 19S proteasome subunit PSMD11 (known as RPN-6 in Caenorhabditis elegans) and a corresponding increased assembly of the 26S/30S proteasome
AMP-activated protein kinase is able to interact physically with this subunit and modify its phosphorylation status.
interaction with ubiquitinated NF-kappaB2/p100
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits\; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the proteasome subunit S9 family that functions as a non-ATPase subunit of the 19S regulator and is phosphorylated by AMP-activated protein kinase. Alternatively spliced transcript variants have been observed for this gene.
proteasome 26S non-ATPase subunit 11
, 26S proteasome non-ATPase regulatory subunit 11B
, 26S proteasome regulatory subunit RPN6-B
, proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
, 26S proteasome non-ATPase regulatory subunit 11
, 26S proteasome regulatory subunit 9
, 26S proteasome regulatory subunit RPN6
, 26S proteasome regulatory subunit S9
, 26S proteasome regulatory subunit p44.5