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Deubiquitylase POH1 stabilizes E2F1 protein through binding (show E2F1 Proteins)to and deubiquitylating E2F1 in liver cancer.
The data demonstrated that proteasomal POH1 is a key de-ubiquitinating enzyme that regulates ubiquitin conjugates generated in response to damage and that several aspects of the DNA double-strand break response are regulated by the proteasome.
Disorder of POH1 expression is involved in the onset of idiopathic nephrotic syndrome (INS (show INS Proteins)), and confers multidrug resistance in children with INS (show INS Proteins)
Down-regulation of PSMD14 results in decreased cell proliferation, cell cycle arrest and senescence. A comparative study with PSMB5 (show PSMB5 Proteins), revealed that PSMB5 (show PSMB5 Proteins) and PSMD14 have different effects on cell cycle, senescence and associated molecular events.
Ectopic expression of POH1 in HEK293 cells decreased the level of c-Jun (show JUN Proteins) ubiquitination, leading to significant accumulation of the protein and a corresponding increase in AP1 (show FOSB Proteins)-mediated gene expression
An intact zinc metalloproteinase motif of Poh1 is essential for cell viability and 26S proteasome (show Psmd4 Proteins) function.
Specificity for K63-linked polyubiquitin (show UBB Proteins) is a common property of the JAMM/MPN (show PRSS27 Proteins)+ family of deubiquitinating enzymes.
Conditional knockout of Poh1 alleles results in reduced E2F1 (show E2F1 Proteins) expression in primary mouse liver cells.
These results identify a novel mechanism of Mitf (show MITF Proteins) regulation in osteoclasts by POH1.
This gene encodes a component of the 26S proteasome. The 26S proteasome is a large multiprotein complex that catalyzes the degradation of ubiquitinated intracellular proteins. The encoded protein is a component of the 19S regulatory cap complex of the 26S proteasome and mediates substrate deubiquitination. A pseudogene of this gene is also located on the long arm of chromosome 2.
26S proteasome non-ATPase regulatory subunit 14
, 26S proteasome regulatory subunit rpn11
, 26S proteasome-associated PAD1 homolog 1
, 26S proteasome non-ATPase subunit
, 26S proteasome-associated pad1 homolog
, proteasome 26S subunit, non-ATPase 14
, proteasome (prosome, macropain) 26S subunit, non-ATPase, 14