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Such a modulation of proteasome activity is explained, at least in part, by the circadian expression of both Nuclear factor (erythroid-derived 2)-like 2 (Nrf2 (show NFE2L2 Proteins)) and the proteasome activator PA28ab
Results show that PA28alpha was found to be overexpressed in oral squamous cell carcinoma cell lines and tumor tissues. High expression of PA28alpha was significantly associated with recurrence and poorer overall survival.
Constitutive expression of PA28 and ERAP1 (show ERAP1 Proteins) in melanoma cells indicate that both interfere with MART-1 (show MLANA Proteins)(26-35) epitope generation even in the absence of IFN-gamma (show IFNG Proteins)
PA28 selectively up-regulates the presentation of viral MHC class I epitopes and that down regulation PA28 in tumor cells results in impaired presentation of a human TRP2 (show DCT Proteins) tumor antigen.
Impaired expression of proteasome subunits is involved in the loss of HLA class I (show MICA Proteins) expression in human colon cancer cells.
The relationship between anti-PA28alpha and Ki antibodies suggests the importance of an antigen-driven system in the induction of an autoimmune response to PA28 complex.
DJ-1 (show PARK7 Proteins) and PA28alpha may have roles in the onset of hepatocarcinogenesis
the 11S proteasome activator complex, Reg alpha fragment, may have a role in ovarian cancer
Inhibiting accumulation of PA28alpha using microRNA counteracted the removal of damaged proteins demonstrating that PA28alphabeta has a role required for resetting the levels of protein damage at the transition from self-renewal to cell differentiation.
Nrf2 (show NFE2L2 Proteins)-dependent induction of proteasome and Pa28alphabeta regulator are required for adaptation to oxidative stress.
demonstrate that PA28 and the proteasome immunosubunits use fundamentally different mechanisms to enhance the supply of MHC class I-binding peptides
the processing of antigens is regulated by two distinct pathways, one requiring PA28 and the other hsp90 (show HSP90 Proteins)
In immature dendritic cells, the assembly of PA28 alpha beta complexes appears to be limited by the low expression of PA28 beta (show PSME2 Proteins), whereas PA28 alpha expression is already high.
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits\; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the alpha subunit of the 11S regulator, one of the two 11S subunits that is induced by gamma-interferon. Three alpha and three beta subunits combine to form a heterohexameric ring. Two transcripts encoding different isoforms have been identified.
proteasome activator complex subunit 1
, proteasome activator subunit 1
, 11S regulator complex subunit alpha
, activator of multicatalytic protease subunit 1
, protease (prosome, macropain) 28 subunit, alpha
, proteasome (prosome, macropain) 28 subunit, alpha
, proteasome activator 28 subunit alpha
, 29-kD MCP activator subunit
, IGUP I-5111
, interferon gamma up-regulated I-5111 protein
, interferon-gamma IEF SSP 5111
, interferon-gamma-inducible protein 5111
, PA28 alpha subunit
, proteasome activator 28 alpha subunit
, proteasome activator PA28 alpha subunit