Browse our RRM2 Proteins (RRM2)

Full name:: Ribonucleotide Reductase M2 Proteins (RRM2)

On www.antibodies-online.com are 13 Ribonucleotide Reductase M2 (RRM2) Proteins from 7 different suppliers available. Additionally we are shipping RRM2 Antibodies (77) and RRM2 Kits (13) and many more products for this protein. A total of 113 RRM2 products are currently listed.

Synonyms:: AA407299, cb111, chunp6884, r2, RR2, rr2m, rrm2

list all proteins	Gene Name	GeneID	UniProt
	RRM2	6241	P31350
	RRM2	20135	P11157
	RRM2	362720	Q4KLN6
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RRM2 Proteins (RRM2) by Origin

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Relevant Pathways for RRM2 Proteins

Mitotic G1-G1/S Phases

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Human Ribonucleotide Reductase M2 (RRM2) interaction partners

Cyclin F (show CCNF Proteins) and ribonucleotide reductase family member 2 (RRM2) compose a functional axis responsible for nucleotide metabolism. Impairment in this pathway may contribute to increased DNA damage repair and drug resistance. Additionally, we analyzed the expression of RRM2 mRNA and discovered that high expression of RRM2 is associated with worse overall survival.
overexpression of RRM2 is associated with the genesis and progression of neuroblastoma (show ARHGEF16 Proteins), and may be a potential chemotherapeutic target
Data suggest that targeting of breast cancer 1 (show BRCA1 Proteins), early onset protein (BRCA1)-ribonucleotide reductase regulatory subunit M2 (RRM2) axis may represent a paradigm for therapeutic intervention in glioblastoma (GBM).
These results demonstrate that gambogic acid sensitizes pancreatic cancer cells to gemcitabine in vitro and in vivo by inhibiting the activation of the ERK (show EPHB2 Proteins)/E2F1 (show E2F1 Proteins)/RRM2 signaling pathway.
OX2 and RRM2 are suggested to be prominent markers for breast cancer metastasis.
SLFN11 contributes to the sensitivity of Ewing sarcoma cells to inhibition of ribonucleotide reductase M2
TP53 (show TP53 Proteins) mutant cancer cells had elevation of ribonucleotide reductase subunit 1 (RRM1 (show RRM1 Proteins)) and 2 (RRM2), which was reduced by inhibition of mTORC1.
Results indicate CREB1 (show CREB1 Proteins) as a critical transcription factor of RRM2 which promotes tumor aggressiveness, and imply a significant correlation between CREB1 (show CREB1 Proteins) and RRM2 in CRC (show CALR Proteins) specimens.
These findings suggest that the identified APLP2 (show APLP2 Proteins), RRM2, and PRC1 (show PRC1 Proteins) signature could be useful for distinguishing between benign (follicular adenoma) and malignant (follicular carcionma and follicular variant of papillary carcinoma) tumors of the thyroid follicular epithelium.
Data show that inhibition of sphingosine kinase-2 (show SPHK2 Proteins) by ABC294640 is synergistically cytotoxic with gemcitabine toward three pancreatic cancer cell lines, resulting in decreased expression of both ribonucleotide reductase regulatory subunit M2 (RRM2) and c-MYC (show MYC Proteins) protein (Myc (show MYC Proteins)) in all three cell lines.

Mouse (Murine) Ribonucleotide Reductase M2 (RRM2) interaction partners

This work reveals that binding of RRM1 (show RRM1 Proteins) to RRM2 is essential for mammalian cells and provides the first loss-of-function model of the ribonucleotide reductase complex for genetic studies.
mice carrying extra alleles of the RNR (show REN1 Proteins) regulatory subunit RRM2 (Rrm2(TG)) present supraphysiological RNR (show REN1 Proteins) activity and reduced chromosomal breakage at fragile sites
analysis of transgenic overexpression of ribonucleotide reductase Rrm1 (show RRM1 Proteins) and Rrm2 improves cardiac performance
Cinobufotalin significantly inhibits the growth of the xenografts of endometrial carcinoma Ishikawa in nude mice by inhibiting RRM2 expression.
Data suggest that RRM2 may be an important effector of progesterone signaling to induce cell proliferation and decidualization in uterus.
illegitimate recombination initiated by c-Myc (show MYC Proteins)
Adrenergic stimulation of brown adipocytes elevates ribonucleotide reductase subunit R2 in the proliferative stage of adipocyte development; mediating pathways include cAMP/PKA cascades, Src (show SRC Proteins) and Erk (show EPHB2 Proteins) Map Kinases.
S Phase-specific transcription of the mouse ribonucleotide reductase R2 gene requires both a proximal repressive E2F (show E2F1 Proteins)-binding site and an upstream promoter activating region
Chk1 is required for DNA replication at least through regulating RNR2 gene transcription.
results indicate that the affinity of the RNR (show REN1 Proteins) R2 proteins for binding metals is determined by the nature of one specific residue in the vicinity of the dimetal site, namely the one that carries the tyrosyl radical in class Ia and Ib R2 proteins

Zebrafish Ribonucleotide Reductase M2 (RRM2) interaction partners

RRM2 Protein Profile

Protein Summary

This gene encodes one of two non-identical subunits for ribonucleotide reductase. This reductase catalyzes the formation of deoxyribonucleotides from ribonucleotides. Synthesis of the encoded protein (M2) is regulated in a cell-cycle dependent fashion. Transcription from this gene can initiate from alternative promoters, which results in two isoforms that differ in the lengths of their N-termini. Related pseudogenes have been identified on chromosomes 1 and X.

Alternative names and synonyms associated with RRM2

ribonucleotide reductase regulatory subunit M2 (RRM2)
ribonucleotide reductase M2 (Rrm2)
ribonucleotide reductase regulatory subunit M2 (Rrm2)
ribonucleotide reductase M2, gene 2 L homeolog (rrm2.2.L)
ribonucleotide reductase M2, gene 1 (rrm2.1)
ribonucleotide reductase regulatory subunit M2 (rrm2)
ribonucleotide reductase M2 polypeptide (rrm2)

AA407299 protein
cb111 protein
chunp6884 protein
r2 protein
RR2 protein
rr2m protein
rrm2 protein

Protein level used designations for RRM2

ribonucleoside-diphosphate reductase subunit M2 , ribonucleotide reductase M2 polypeptide , ribonucleotide reductase small chain , ribonucleotide reductase small subunit , ribonucleoside-diphosphate reductase M2 chain , Ribonucleotide reductase 2 , etID309896.20 , reductase M2 polypeptide variant 1 , reductase M2 polypeptide variant 2 , reductase M2 polypeptide variant 3a , reductase M2 polypeptide variant 3b , reductase M2 polypeptide variant 3c , reductase M2 polypeptide variant 3d , ribonucleotide reductase protein r2 class I

GENE ID	SPECIES
6241	Homo sapiens
20135	Mus musculus
362720	Rattus norvegicus
380465	Xenopus laevis
394645	Xenopus (Silurana) tropicalis
421936	Gallus gallus
482963	Canis lupus familiaris
508167	Bos taurus
703138	Macaca mulatta
100231721	Taeniopygia guttata
100304963	Ictalurus punctatus
100346325	Oryctolagus cuniculus
100316853	Sus scrofa
30733	Danio rerio
100715474	Cavia porcellus
100072410	Equus caballus

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