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Cyclin F (show CCNF Proteins) and ribonucleotide reductase family member 2 (RRM2) compose a functional axis responsible for nucleotide metabolism. Impairment in this pathway may contribute to increased DNA damage repair and drug resistance. Additionally, we analyzed the expression of RRM2 mRNA and discovered that high expression of RRM2 is associated with worse overall survival.
overexpression of RRM2 is associated with the genesis and progression of neuroblastoma (show ARHGEF16 Proteins), and may be a potential chemotherapeutic target
Data suggest that targeting of breast cancer 1 (show BRCA1 Proteins), early onset protein (BRCA1)-ribonucleotide reductase regulatory subunit M2 (RRM2) axis may represent a paradigm for therapeutic intervention in glioblastoma (GBM).
These results demonstrate that gambogic acid sensitizes pancreatic cancer cells to gemcitabine in vitro and in vivo by inhibiting the activation of the ERK (show EPHB2 Proteins)/E2F1 (show E2F1 Proteins)/RRM2 signaling pathway.
OX2 and RRM2 are suggested to be prominent markers for breast cancer metastasis.
SLFN11 contributes to the sensitivity of Ewing sarcoma cells to inhibition of ribonucleotide reductase M2
TP53 (show TP53 Proteins) mutant cancer cells had elevation of ribonucleotide reductase subunit 1 (RRM1 (show RRM1 Proteins)) and 2 (RRM2), which was reduced by inhibition of mTORC1.
Results indicate CREB1 (show CREB1 Proteins) as a critical transcription factor of RRM2 which promotes tumor aggressiveness, and imply a significant correlation between CREB1 (show CREB1 Proteins) and RRM2 in CRC (show CALR Proteins) specimens.
These findings suggest that the identified APLP2 (show APLP2 Proteins), RRM2, and PRC1 (show PRC1 Proteins) signature could be useful for distinguishing between benign (follicular adenoma) and malignant (follicular carcionma and follicular variant of papillary carcinoma) tumors of the thyroid follicular epithelium.
Data show that inhibition of sphingosine kinase-2 (show SPHK2 Proteins) by ABC294640 is synergistically cytotoxic with gemcitabine toward three pancreatic cancer cell lines, resulting in decreased expression of both ribonucleotide reductase regulatory subunit M2 (RRM2) and c-MYC (show MYC Proteins) protein (Myc (show MYC Proteins)) in all three cell lines.
This work reveals that binding of RRM1 (show RRM1 Proteins) to RRM2 is essential for mammalian cells and provides the first loss-of-function model of the ribonucleotide reductase complex for genetic studies.
mice carrying extra alleles of the RNR (show REN1 Proteins) regulatory subunit RRM2 (Rrm2(TG)) present supraphysiological RNR (show REN1 Proteins) activity and reduced chromosomal breakage at fragile sites
analysis of transgenic overexpression of ribonucleotide reductase Rrm1 (show RRM1 Proteins) and Rrm2 improves cardiac performance
Cinobufotalin significantly inhibits the growth of the xenografts of endometrial carcinoma Ishikawa in nude mice by inhibiting RRM2 expression.
Data suggest that RRM2 may be an important effector of progesterone signaling to induce cell proliferation and decidualization in uterus.
illegitimate recombination initiated by c-Myc (show MYC Proteins)
Adrenergic stimulation of brown adipocytes elevates ribonucleotide reductase subunit R2 in the proliferative stage of adipocyte development; mediating pathways include cAMP/PKA cascades, Src (show SRC Proteins) and Erk (show EPHB2 Proteins) Map Kinases.
S Phase-specific transcription of the mouse ribonucleotide reductase R2 gene requires both a proximal repressive E2F (show E2F1 Proteins)-binding site and an upstream promoter activating region
Chk1 is required for DNA replication at least through regulating RNR2 gene transcription.
results indicate that the affinity of the RNR (show REN1 Proteins) R2 proteins for binding metals is determined by the nature of one specific residue in the vicinity of the dimetal site, namely the one that carries the tyrosyl radical in class Ia and Ib R2 proteins
This gene encodes one of two non-identical subunits for ribonucleotide reductase. This reductase catalyzes the formation of deoxyribonucleotides from ribonucleotides. Synthesis of the encoded protein (M2) is regulated in a cell-cycle dependent fashion. Transcription from this gene can initiate from alternative promoters, which results in two isoforms that differ in the lengths of their N-termini. Related pseudogenes have been identified on chromosomes 1 and X.
ribonucleoside-diphosphate reductase subunit M2
, ribonucleotide reductase M2 polypeptide
, ribonucleotide reductase small chain
, ribonucleotide reductase small subunit
, ribonucleoside-diphosphate reductase M2 chain
, Ribonucleotide reductase 2
, reductase M2 polypeptide variant 1
, reductase M2 polypeptide variant 2
, reductase M2 polypeptide variant 3a
, reductase M2 polypeptide variant 3b
, reductase M2 polypeptide variant 3c
, reductase M2 polypeptide variant 3d
, ribonucleotide reductase protein r2 class I