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Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation (By similarity).
CLL-associated antigen KW-2
, PRIP-interacting protein PIPMT
, PRIP-interacting protein with methyltransferase domain
, PRIP-interacting protein with methyltransferase motif
, cap-specific guanine-N2 methyltransferase
, hepatocellular carcinoma-associated antigen 137
, nuclear receptor coactivator 6 interacting protein
, nuclear receptor coactivator 6-interacting protein
, trimethylguanosine synthase
, trimethylguanosine synthase homolog
, LOW QUALITY PROTEIN: trimethylguanosine synthase