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Data show that knockdown of thymidylate synthase (TS) significantly impairs TH17 and TH1 cell differentiation.
Possible interaction routes between hydrophobic residues of the mouse thymidylate synthase protein N-terminal segment and the active site are also discussed
SHMT1 and TYMS localization to the nucleus is essential to prevent uracil accumulation in DNA
Synergistic activation of the TATA-less thymidylate synthase promoter by the Ets transcription factor GABP and Sp1.
downregulation of expression results in block of cell cycle expression when influenced by Fe65
posttranslationally-modified thymidylate synthase is associated with cell resistance to 5-fluoro-dUrd
High expression of Thymidylate Synthase is associated with resistance of 5-Fluorouracil in Oral Squamous Cell Carcinoma
The TYMS 6-bp deletion and 2R3R polymorphism were not associated with MTX-induced oral mucositis. Validation studies in prospective cohorts are necessary to assess the possible role of the low-expression TYMS genotypes in relation to MTX-induced oral mucositis.
positive expression of TS was a significant predictor of worse progression free survival in patients with clinical stage 1 cutaneous angiosarcoma
24 hr. pretreatment with dexamethasone, but not same day co-administration of dexamethasone with therapy, impairs the TS inhibition-mediated "flare" in thymidine salvage pathway activity in non-small cell lung cancer.
Thymidylate synthase (TS) expression was positively correlated with lymphatic metastasis and negatively correlated with the overall survival (OS) in pancreatic ductal adenocarcinoma (PDA) patients.
A statistically significant association between methylenetetrahydrofolate reductase (MTHFR) 677T/T, thymidylate synthase (TS) 5'-untranslated region (UTR) 3RG, TS 3'-UTR -6 bp/-6 bp, XRCC1 399G/G genotypes and short survival was found in patients receiving best supportive care (BSC)by multivariate analysis
No significant association has been found between rs495139 in the TYMS-ENOSF1 region and risk of ovarian carcinoma of mucinous histology. (Meta-analysis)
TYMS 2R3R polymorphism and the -[IVS]14+1G>A mutation in DPYD was not associated with susceptibility to CRC. However, the 2R/2R and 2R/3R genotypes of TYMS polymorphism could significantly contribute to hematological and gastric toxicity in CRC patients in this sample population
The significant ethnic differences in the distributions of the TYMS rs2790 A > G polymorphism.
TYMS was determined to form an octamer, depending on the presence of Cys43-disulfide.
TYMS SNPs are associated with susceptibility to osteoporosis and osteoporotic vertebral compression fractures in postmenopausal women.
thymidylate synthase appears to be a clinically relevant predictive biomarker in patients with resected colorectal liver metastases receiving systemic 5-FU
In MAGIC, patients with a TS 2R/2R genotype appeared to derive a larger benefit from perioperative ECF chemotherapy than patients with 3R containing genotypes.
human (hs) TSase and its contrasts and the similarities to the well-studied Escherichia coli (ec) TSase
the present results indicate that the EGFR mutation status and TS and ERCC1 expression can be used as the predictors of overall survival after subsequent second-line treatments for adenocarcinoma non-small-cell lung cancer
The results indicate that TS 3 -UTR 6-bp insertion and MTHFR 677T and 1298C alleles increase 5-flourouracil resistance in colorectal cancer cells.
Homocysteine levels might effect the disease activity and toxicity of MTX but 2R and 3R polymorphisms in the Thymidylate synthase gene, were not related with methotrexate-related toxicity in rheumatoid arthritis patients receiving folate supplementation.
This study demonstrates a significant correlation between low TS expression levels and long-term prognosis of patients with lung cancer.
Two SNPs (rs523230 and rs9967368) in TYMS gene were significantly associated with the overall survival of HCC patients.
results indicate XRCC3 Thr241Met and TYMS 5'-UTR VNTR polymorphisms are associated with time-to-metastasis, and may have potential biological roles in expediting the metastatic process
Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occuring antisense transcript rTSalpha (GeneID:55556) vary inversely when cell-growth progresses from late-log to plateau phase.
, thymidylate synthase
, thymidylate synthetase
, thymidylate synthase-like