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Data show that knockdown of thymidylate synthase (TS) significantly impairs TH17 and TH1 cell differentiation.
Possible interaction routes between hydrophobic residues of the mouse thymidylate synthase protein N-terminal segment and the active site are also discussed
SHMT1 and TYMS localization to the nucleus is essential to prevent uracil accumulation in DNA
Synergistic activation of the TATA-less thymidylate synthase promoter by the Ets transcription factor GABP and Sp1.
downregulation of expression results in block of cell cycle expression when influenced by Fe65
posttranslationally-modified thymidylate synthase is associated with cell resistance to 5-fluoro-dUrd
upregulation in pancreatic cancer leads to unfavorable overall survival and recurrence-free survival
TYMS was absent in 100% of circulating tumor cells (CTCs) from locally advanced rectal cancer patients with pathologic complete response yet was expressed in 83% of non-responders prior to surgery (S2). RAD23B was expressed in CTCs from 75% of non-responders prior to neoadjuvant chemoradiation (S1) and in 100% of non-responders at S2. 100% of non-responders expressed TYMS mRNA at both timepoints.
Thymidylate synthetase enhancer region polymorphisms were associated with susceptibility to metabolic syndrome in Korean population.
our data show that FOXM1 regulates TYMS expression to modulate 5-FU resistance in cholangiocarcinoma (CCA) and that severe 5-FU resistance can be caused by the uncoupling of the regulation of TYMS by FOXM1. Our findings suggest that the FOXM1-TYMS axis can be a novel diagnostic, predictive and prognostic marker as well as a therapeutic target for CCA.
Deciphering Clinicoradiologic Phenotype for Thymidylate Synthase Expression Status in Patients with Advanced Lung Adenocarcinoma Using a Radiomics Approach.
This meta-analysis demonstrates that the TYMS 2R/3R and 6bp I/D polymorphisms may not be associated with non-responsiveness to or toxicity of MTX therapy in RA patients [meta-analysis]
High expression of Thymidylate Synthase is associated with resistance of 5-Fluorouracil in Oral Squamous Cell Carcinoma
The TYMS 6-bp deletion and 2R3R polymorphism were not associated with MTX-induced oral mucositis. Validation studies in prospective cohorts are necessary to assess the possible role of the low-expression TYMS genotypes in relation to MTX-induced oral mucositis.
positive expression of TS was a significant predictor of worse progression free survival in patients with clinical stage 1 cutaneous angiosarcoma
24 hr. pretreatment with dexamethasone, but not same day co-administration of dexamethasone with therapy, impairs the TS inhibition-mediated "flare" in thymidine salvage pathway activity in non-small cell lung cancer.
Thymidylate synthase (TS) expression was positively correlated with lymphatic metastasis and negatively correlated with the overall survival (OS) in pancreatic ductal adenocarcinoma (PDA) patients.
A statistically significant association between methylenetetrahydrofolate reductase (MTHFR) 677T/T, thymidylate synthase (TS) 5'-untranslated region (UTR) 3RG, TS 3'-UTR -6 bp/-6 bp, XRCC1 399G/G genotypes and short survival was found in patients receiving best supportive care (BSC)by multivariate analysis
No significant association has been found between rs495139 in the TYMS-ENOSF1 region and risk of ovarian carcinoma of mucinous histology. (Meta-analysis)
TYMS 2R3R polymorphism and the -[IVS]14+1G>A mutation in DPYD was not associated with susceptibility to CRC. However, the 2R/2R and 2R/3R genotypes of TYMS polymorphism could significantly contribute to hematological and gastric toxicity in CRC patients in this sample population
The significant ethnic differences in the distributions of the TYMS rs2790 A > G polymorphism.
TYMS was determined to form an octamer, depending on the presence of Cys43-disulfide.
TYMS SNPs are associated with susceptibility to osteoporosis and osteoporotic vertebral compression fractures in postmenopausal women.
thymidylate synthase appears to be a clinically relevant predictive biomarker in patients with resected colorectal liver metastases receiving systemic 5-FU
In MAGIC, patients with a TS 2R/2R genotype appeared to derive a larger benefit from perioperative ECF chemotherapy than patients with 3R containing genotypes.
human (hs) TSase and its contrasts and the similarities to the well-studied Escherichia coli (ec) TSase
Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occuring antisense transcript rTSalpha (GeneID:55556) vary inversely when cell-growth progresses from late-log to plateau phase.
, thymidylate synthase
, thymidylate synthetase
, thymidylate synthase-like