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Data show that knockdown of thymidylate synthase (TS) significantly impairs TH17 and TH1 (show HAND1 Proteins) cell differentiation.
Possible interaction routes between hydrophobic residues of the mouse thymidylate synthase protein N-terminal segment and the active site are also discussed
SHMT1 (show SHMT1 Proteins) and TYMS localization to the nucleus is essential to prevent uracil accumulation in DNA
Synergistic activation of the TATA-less thymidylate synthase promoter by the Ets transcription factor (show ELF2 Proteins) GABP and Sp1 (show SP1 Proteins).
downregulation of expression results in block of cell cycle expression when influenced by Fe65 (show APBB1 Proteins)
posttranslationally-modified thymidylate synthase is associated with cell resistance to 5-fluoro-dUrd
Two SNPs (rs523230 and rs9967368) in TYMS gene were significantly associated with the overall survival of HCC (show FAM126A Proteins) patients.
results indicate XRCC3 Thr241Met and TYMS 5'-UTR VNTR polymorphisms are associated with time-to-metastasis, and may have potential biological roles in expediting the metastatic process
Moreover, we found that genotypes rs34743033 3R/2R, rs16430 ins6/del6, rs1045642 CC or CT, and rs2032582 GG were beneficial predictors of clinical treatment outcome in AGC (show ACAN Proteins) patients, suggesting some clinical implications in chemotherapy of a Chinese population.
High TOP2A (show TOP2A Proteins) expression was significantly associated with longer time to progression after EDP-M. TOP2A (show TOP2A Proteins) and TS proteins assessed by immunohistochemistry significantly correlated with mRNA expression. Immunohistochemical TOP2A (show TOP2A Proteins) expression was associated with a non-significant better response and longer TTP (show ADAMTS13 Proteins) after EDP-M.
This study aimed to explore the associations between MTHFR (show MTHFR Proteins) or TS genetic polymorphisms and susceptibility to acute lymphocytic leukemia (ALL) in children.
Dihydrofolate reductase (show DHFR Proteins) and thymidylate synthase form a complex in vitro and co-localize in normal and cancer cells.
High expression level of TYMS is associated with neuroendocrine lung tumors.
This study finds that measurement of tumor levels of thymidylate synthase is not helpful in assigning specific adjuvant treatment for colorectal cancer. It also highlights the importance of using prospective analyses within treatment clinical trials as the optimal method of determining biomarker utility.
Study shows that the TYMS TSER 3R allele increases the risk of thymic lymphoid hyperplasia in AChR+ Myasthenia Gravis (MG) patients and that the 3R allele in the promoter enhancer region results in increased protein production required for the synthesis of DNA precursors.
polymorphisms of TS 5'-UTR 2R (double repeats)/3R (triple repeats) of a 28-bp sequence (11 articles) and 3'-UTR del6/ins6 (seven articles) were not significantly associated with increased risk of gastric cancer.
Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occuring antisense transcript rTSalpha (GeneID:55556) vary inversely when cell-growth progresses from late-log to plateau phase.
, thymidylate synthase
, thymidylate synthetase
, thymidylate synthase-like