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Data show that knockdown of thymidylate synthase (TS) significantly impairs TH17 and TH1 (show HAND1 Proteins) cell differentiation.
Possible interaction routes between hydrophobic residues of the mouse thymidylate synthase protein N (show NP Proteins)-terminal segment and the active site are also discussed
SHMT1 (show SHMT1 Proteins) and TYMS localization to the nucleus is essential to prevent uracil accumulation in DNA
Synergistic activation of the TATA-less thymidylate synthase promoter by the Ets transcription factor (show ELF2 Proteins) GABP and Sp1 (show SP1 Proteins).
downregulation of expression results in block of cell cycle expression when influenced by Fe65 (show APBB1 Proteins)
posttranslationally-modified thymidylate synthase is associated with cell resistance to 5-fluoro-dUrd
TYMS 2R3R polymorphism and the -[IVS]14+1G>A mutation in DPYD (show DPYD Proteins) was not associated with susceptibility to CRC (show CALR Proteins). However, the 2R/2R and 2R/3R genotypes of TYMS polymorphism could significantly contribute to hematological and gastric toxicity in CRC (show CALR Proteins) patients in this sample population
The significant ethnic differences in the distributions of the TYMS rs2790 A > G polymorphism.
TYMS was determined to form an octamer, depending on the presence of Cys43-disulfide.
TYMS SNPs are associated with susceptibility to osteoporosis and osteoporotic vertebral compression fractures in postmenopausal women.
thymidylate synthase appears to be a clinically relevant predictive biomarker in patients with resected colorectal liver metastases receiving systemic 5-FU
human (hs) TSase and its contrasts and the similarities to the well-studied Escherichia coli (ec) TSase
the present results indicate that the EGFR (show EGFR Proteins) mutation status and TS and ERCC1 (show ERCC1 Proteins) expression can be used as the predictors of overall survival after subsequent second-line treatments for adenocarcinoma non-small-cell lung cancer
The results indicate that TS 3 -UTR 6-bp insertion and MTHFR (show MTHFR Proteins) 677T and 1298C alleles increase 5-flourouracil resistance in colorectal cancer cells.
Homocysteine levels might effect the disease activity and toxicity of MTX (show MTX1 Proteins) but 2R and 3R polymorphisms in the Thymidylate synthase gene, were not related with methotrexate-related toxicity in rheumatoid arthritis patients receiving folate supplementation.
Two SNPs (rs523230 and rs9967368) in TYMS gene were significantly associated with the overall survival of HCC (show FAM126A Proteins) patients.
Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occuring antisense transcript rTSalpha (GeneID:55556) vary inversely when cell-growth progresses from late-log to plateau phase.
, thymidylate synthase
, thymidylate synthetase
, thymidylate synthase-like