Protein Summary

This gene encodes a member of the hydratase/isomerase superfamily. The gene product shows high sequence similarity to enoyl-coenzyme A (CoA) hydratases of several species, particularly within a conserved domain characteristic of these proteins. The encoded protein, which contains a C-terminal peroxisomal targeting sequence, localizes to the peroxisome. The rat ortholog, which localizes to the matrix of both the peroxisome and mitochondria, can isomerize 3-trans,5-cis-dienoyl-CoA to 2-trans,4-trans-dienoyl-CoA, indicating that it is a delta3,5-delta2,4-dienoyl-CoA isomerase. This enzyme functions in the auxiliary step of the fatty acid beta-oxidation pathway. Expression of the rat gene is induced by peroxisome proliferators.

Alternative names and synonyms associated with ECH1

• enoyl-CoA hydratase 1, peroxisomal (ech1) antibody
• enoyl CoA hydratase 1, peroxisomal (ECH1) antibody
• enoyl-CoA hydratase 1 (ECH1) antibody
• delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial (LOC747511) antibody
• enoyl-CoA hydratase 1, peroxisomal L homeolog (ech1.L) antibody
• Show all gene names
• enoyl-CoA hydratase 1 (Ech1) antibody
• enoyl coenzyme A hydratase 1, peroxisomal (Ech1) antibody

• AA617331 antibody
• HPXEL antibody
• Pxel antibody

Protein level used designations for ECH1

enoyl Coenzyme A hydratase 1, peroxisomal , delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial , peroxisomal enoyl-coenzyme A hydratase-like protein , delta3,5-delta2,4-dienoyl-CoA isomerase , dienoyl-CoA isomerase , peroxisomal enoyl-CoA hydratase 1 , peroxisomal enoyl coenzyme A hydratase 1 , ECH1-like protein , Peroxisomal enoyl hydratase-like protein , enoyl coenzyme A hydratase 1, peroxisomal , enoyl hydratase-like protein peroxisomal , enoyl hydratase-like protein, peroxisomal , peroxisomal/mitochondrial dienoyl-CoA isomerase