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demonstrate for the first time exosomal enrichment of G-protein-coupled receptor kinase (GRK) 5 (show GRK5 Proteins) and GRK6, both of which regulate Src (show SRC Proteins) and IGF-IR signaling and have been implicated in cancer.
Genetic variation in OXTR (show OXTR Proteins) and GRK6 is associated with the amount of oxytocin required as well as the duration of labor and risk for cesarean delivery among women undergoing induction of labor near term.
This work demonstrates the importance of GRK6 in regulation of hematopoietic stem cell self-renewal and reveals its potential role in participation of stress response.
Decreased expression of GRK6 may serve as an independent predictor of overall survival in lung adenocarcinoma.
The expression of GRK6 mRNA and protein was significantly lower in hypopharyngeal squamous cell carcinoma than in corresponding adjacent non-tumor tissues. This was associated with aberrant methylation of the gene.
Our results imply that GRK6 may not play a role in the pathophysiology of schizophrenia among Han Chinese
these results indicate that GRK6 complexes with AGS3 (show GPSM1 Proteins)-Galphai2 (show GNAI2 Proteins) to regulate CXCR2 (show CXCR2 Proteins)-mediated leukocyte functions at different levels, including downstream effector activation, receptor trafficking, and expression at the cell membrane.
GRK6 plays a predominant role in phosphorylation of FFA receptor (FFA)4.
results suggested that GRK6 overexpression plays an important role in hepatocellular carcinoma
Downregulation of GRK6 expression enhances CXCR4 (show CXCR4 Proteins) signaling and promoted medulloblastoma cell migration.
GRK6-mediated OXTR (show OXTR Proteins) desensitization in labor is necessary for normal uterine contractile patterns and optimal fetal outcome.
GRK6 directly phosphorylates Nfkbia (show NFKBIA Proteins) at Ser32/Ser36. Knockdown of GRK6 suppresses TNF-alpha (show TNF Proteins)-induced NF-kappaappaB signaling.
data demonstrate that GRK6 plays a feedback regulatory role in CXCR2 (show CXCR2 Proteins)-mediated tumor development, invasion and metastasis
G-protein-coupled receptor kinase 6 (GRK6) is involved in apoptotic cell clearance.
Chemokine receptor CXCR2 (show CXCR2 Proteins) interacts with GRK6 to negatively regulate receptor sensitization and trafficking, thus affecting cell signaling and angiogenesis.
Results identify GRK5 (show GRK5 Proteins)/6 as novel kinases for the single transmembrane receptor LRP6 (show LRP6 Proteins) during Wnt (show WNT2 Proteins) signaling.
Postsynaptic D2-like dopamine receptors are physiological targets for GRK6 and suggests that this regulatory mechanism contributes to central dopaminergic supersensitivity.
In the absence of GRK6, the G-CSF (show CSF3 Proteins)-induced increase in circulating neutrophils is profoundly impaired. After injection of pegylated-G-CSF (show CSF3 Proteins), significantly lower numbers of circulating neutrophils were observed in GRK6-/- as compared with wild-type (WT) mice.
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. Several transcript variants encoding different isoforms have been described for this gene.
G protein-coupled receptor kinase 6
, G protein-coupled receptor kinase 6-like
, g protein-coupled receptor kinase GRK6
, G-protein coupled receptor kinase 6