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hypoxia causes PGC (show PGC Proteins) migration defect by inhibiting IGF signaling through the induction of IGFBP-1
The insulin-like growth factor binding protein 1 (29-31kDa)is similarities to mammalian.
HIF-1 (show HIF1A Proteins) mediates hypoxia-induced IGFBP-1 gene expression in early development by selectively interacting with the hypoxia response elements and its adjacent HIF-1 (show HIF1A Proteins) ancillary sequence.
TGE (show TGM3 Proteins) duplicated IGFBP-1 may provide additional flexibility in fine-tuning insulin (show INS Proteins)-like growth factor signaling activities under hypoxia and other catabolic conditions.
IGF2, IGF binding protein 1, and matrix metalloproteinases 2 and 9 in implantation-stage endometrium following immunoneutralization of vascular endothelial growth factor in the rhesus monkey.
NR4A modulates the decidualization of hESCs by upregulating prolactin (PRL (show PRL Proteins)) and insulin-like growth factor binding protein-1 (IGFBP-1) expression and transformation in vitro.
We report interactions between CSNK (show CSN3 Proteins)-2beta and IGFBP-1 as well as mTOR (show FRAP1 Proteins) and CSNK (show CSN3 Proteins)-2beta, providing strong evidence of a mechanistic link between mTOR (show FRAP1 Proteins) and IGF-I (show IGF1 Proteins) signaling, two critical regulators of cell growth via CSNK (show CSN3 Proteins)-2.
IGFBP-1 had a positive linear relation to fracture risk, partly mediated by bone mineral density (BMD (show BEST1 Proteins)) but not related to IGF-I (show IGF1 Proteins) or BMD (show BEST1 Proteins)
We conclude that low BDNF (show BDNF Proteins) and high LCN2 (show LCN2 Proteins) and NF-L (show NEFL Proteins) levels are associated with Multiple Sclerosis (MS) pathogenesis, and high IGFBP1level is a biomarker for female MS only, suggesting different MS progression pathways between the sexes. LCN2 (show LCN2 Proteins) is a candidate predictor of response to natalizumab treatment, and NF-L (show NEFL Proteins) is a candidate predictor of clinically isolated syndrome's (CIS (show CISH Proteins)) conversion into MS.
Results show that IGFBP-1 transcription and FoxO1 (show FOXO1 Proteins) expression are dysregulated in tamoxifen-resistant cancer cells.
Women with higher IGFBP-1 were more likely to have a low relative muscle mass.
Data show that supplementation with selenium and coenzyme Q10 (show EIF2C2 Proteins) over four years resulted in increased levels of IGF-1 (show IGF1 Proteins) and the postprandial IGFBP-1.
Levels of serum IGFBP-1 were shown to be significantly higher in patients with NPCs.
Levels of blood IGFBP-1 in pre- and post-menopausal rheumatoid arthritis patients were significantly higher in comparison to the control group.
ALDH1A1 (show ALDH1A1 Proteins) and IGFBP1 are differentially overexpressed in CLM (show LAMB1 Proteins) and may play a dual role, functioning as both tumor suppressors and metastasis promoters in CRC (show CALR Proteins)
the hepatokine IGFBP1 is a critical liver-bone hormonal relay that promotes osteoclastogenesis and bone resorption as well as an essential mediator of FGF21 (show FGF21 Proteins)-induced bone loss
Data suggest expression of Igfbp1 in liver is regulated by dietary factors; carnosine supplementation down-regulates expression of Igfbp1 in liver of obese/diabetic mice; mechanism involves suppression of Hif1a (hypoxia inducible factor 1 alpha (show HIF1A Proteins)).
During the two week starvation period, both the levels of plasma IGF-1 (show IGF1 Proteins) and IGFBP-1 decreased.
These results show that RTEF-1 (show TEAD4 Proteins)-stimulated IGFBP-1 expression may be central to the mechanism by which RTEF-1 (show TEAD4 Proteins) attenuates blood glucose levels.
Global deletion of Igfbp1 in a c-Myc (show MYC Proteins) transgenic model did not accelerate the development of prostate cancer. Global Igfbp1 deletion did result in a significant increase in body weight and body fat mass.
IGFBP-1 functions as a critical hepatic survival factor in the liver by reducing the level of proapoptotic signals
IGFBP-1 may support liver regeneration at least in part via its effect on MAPK/ERK (show MAPK1 Proteins) and C/EBP beta (show CEBPB Proteins) activities. These findings are the first demonstration of the involvement of IGFBP-1 in the regulation of in vivo mitogenic signaling pathways.
Induction of IFGBP1 expression by amino acid deprivation of HepG2 hepatoma cells involves both a transcriptional activation and an mRNA stabilization due to its 3'UTR.
high concentrations of circulating IGFBP-1 are sufficient to cause fetal growth restriction in an animal model
the IGFBP-1 gene is a primary target of peroxisome proliferator-activated receptors
Allantoic fluid levels of IGFBP-1 were increased in nuclear transfer pregnancies
IGFBP1 is a common endometrial marker of conceptus elongation in sheep and cattle and most likely regulates conceptus elongation by stimulating migration and attachment of the trophectoderm
Results of fluorescence in situ and radiation hybrid (RH) mapping assigned this gene to porcine chromosome (SSC (show CYP11A1 Proteins)) 18q24-qter.
This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors.
insulin-like growth factor binding protein 1
, insulin-like growth factor binding protein-1
, IGF-binding protein 1
, alpha-pregnancy-associated endometrial globulin
, amniotic fluid binding protein
, binding protein-25
, binding protein-26
, binding protein-28
, growth hormone independent-binding protein
, insulin-like growth factor-binding protein 1
, placental protein 12
, INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 1 PRECURSOR (IGFBP-1) (IBP-1) (IGF-BINDING PROTEIN 1)