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These findings indicate cross-talk between platelet activation and inhibition pathways at the level of RGS18 and Gq.
Data show that that SPL/RGS/SHP1 complexes are present in resting platelets where constitutive phosphorylation of SPL(Y398) creates an atypical binding site for SHP-1.
molecular cloning and characterization of RGS18 as a regulator of G protein signalling in human platelets
these results identify Rgs18 as a new and crucial effector of Gfi1b (show GFI1B Proteins) that regulates downstream signaling and gene expression programs to orchestrate erythro-megakaryocytic lineage choices.
Regulator of G-protein signaling 18 controls both platelet generation and function.
Regulated sequestration and release of RGS18 by intracellular binding proteins coordinates activating and inhibitory signaling networks in platelets. Substituting alanine for Ser94 blocks cAMP-induced dissociation of the SPL/RGS/SHP-1 complex.
RGS18 deficiency markedly shortened bleeding as well as occlusion times (in vivo). Furthermore, RGS18(-/-) platelets displayed hyper-responsiveness with regards to agonist induced aggregation
study is the first to show that RGS18 regulates megakaryopoiesis but also reveals its unexpected role in ciliogenesis, at least in lower vertebrates, via interference with Wnt (show WNT2 Proteins) signaling.
RGS18 acts as a negative regulator of the acidosis-induced osteoclastogenic protein-coupled receptor 68/NFAT (show NFATC1 Proteins) signaling pathway
This gene encodes a member of the regulator of G-protein signaling family. This protein is contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.
regulator of G-protein signalling 18
, regulator of G-protein signaling 18
, regulator of G-protein signalling 13