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Human RGS4 Protein expressed in Wheat germ - ABIN1317968
Rivero, Gabilondo, García-Sevilla, La Harpe, Morentín, Javier Meana: Characterization of regulators of G-protein signaling RGS4 and RGS10 proteins in the postmortem human brain. in Neurochemistry international 2010
Study investigated whether RGS4 could participate in signalling pathways to regulate neurotropic events. These observations suggest that RGS4 is implicated in opioid dependent neuronal differentiation and neurite outgrowth via a "non-canonical" signaling pathway regulating STAT5B (show STAT5B Proteins)-directed responses.
Data support the notion that the Galpha (show SUCLG1 Proteins), but not Gbetagamma, arm of the Gi/o signalling is involved in TRPC4 (show TRPC4 Proteins) activation and unveil new roles for RGS (show PITX2 Proteins) and RGS4 in fine-tuning TRPC4 (show TRPC4 Proteins) activities.
The results of this study demonstrated the association between the variation in the regulator of G-protein signaling 4 (RGS4) gene, a putative candidate gene for psychosis previously associated with schizophrenia endophenotypes, and psychotic-like experiences (PLEs).
All of these results confirmed the critical role of RGS4 in NSCLC progression.
After alphao dissociates from MOR, RGS4 remains bound to the C-terminal region of MOR
RGS4 deletion results in a predisposition to atrial fibrillation from enhanced activity in the G-protein pathway, resulting in abnormal calcium release and corresponding electrical events.
RGS2 and RGS4 are new interacting partners that play key roles in G protein coupling to negatively regulate kappa-OmicronR signaling.
RGS4 and COMT (show COMT Proteins) risk variants are associated with brain structural alterations in patient with schizophrenia.
genetic association study in Chinese Han population: Data suggest an SNP in RGS4 (rs10759) is associated with increased predisposition to schizophrenia via down-regulation of miroRNA (MIRN124) binding to 3-prime-untranslated region of RGS4 mRNA.
ectopic expression of R4 subfamily members RGS2 (show RGS2 Proteins), RGS3 (show RGS3 Proteins), RGS4, and RGS5 (show RGS5 Proteins) reduced activated PAR1 (show MARK2 Proteins) wild-type signaling, whereas signaling by the PAR1 (show MARK2 Proteins) AKKAA mutant was minimally affected.
expression of GATA-6 (show GATA6 Proteins) but not GATA-1 (show GATA1 Proteins) significantly increased the constitutive and IL-1beta (show IL1B Proteins)-induced mRNA expression of the endogenous RGS4 in colonic smooth muscle cells
Activation of MEKK1 (show MAP3K1 Proteins)-MKK4 (show MAP2K4 Proteins)-JNK (show MAPK8 Proteins)-AP1 (show JUN Proteins) signaling pathway plays a tonic inhibitory role in regulating Rgs4 transcription in rabbit colonic smooth muscle cells.
These findings suggest that 3'-most AU-rich elements sites within RGS4 3'-UTR are essential for the instability of RGS4 mRNA.
The 5'-untranslated region (UTR) extended 120 bp nucleotides upstream of the Rgs4 start codon; a putative promoter sequence (1389 bp) showed a consensus TATA box and cis (show CISH Proteins)-acting binding sites for several potential transcriptional factors.
The canonical IKK2 (show IKBKB Proteins)/IkappaBalpha (show NFKBIA Proteins) pathway of NF-kappaB (show NFKB1 Proteins) activation mediates the up-regulation of RGS4 expression in response to IL-1beta (show IL1B Proteins).
Upregulation of RGS4 expression by IL-1beta (show IL1B Proteins) in colonic smooth muscle is enhanced by ERK1/2 and p38 MAPK (show MAPK14 Proteins) and inhibited by the PI3K/Akt (show AKT1 Proteins)/GSK3beta pathway.
These results provide support for the hypothesis that increasing RGS4 expression and/or function could be a viable therapeutic strategy for asthma.
RGS4 in the paraventricular nucleus regulates blood corticosteroid-related GABAB receptor signaling during the acute stress response.
Thus, RGS4 expression, specific to renal vascular smooth muscle cells, inhibits angiotensin II-mediated cytokine signaling and macrophage recruitment during reperfusion, distinct from vasomotor regulation.
Spinal RGS4 inhibited the endogenous or exogenous OR-mediated antinociceptive effect in the formalin pain test.
RGS6 (show RGS6 Proteins)-Gbeta5 (show GNB5 Proteins), but not RGS4, is the primary RGS (show PITX2 Proteins) modulator of parasympathetic HR regulation and SAN M2R-IKACh signaling in mice.
dramatic up-regulation of RGS4 expression in the nucleus accumbens of mice treated with monoamine-directed antidepressants
RGS4 expression in mouse embryo is regulated by Lmx1a (show LMX1A Proteins) transcription factor.
A novel nitric oxide-RGS4 signal pathway mechanism that couples cardiac vessel growth with myocyte growth and heart size.
Findings support the concept that the inhibitory effects of SPL (show SGPL1 Proteins) on M3R (show CHRM3 Proteins) activity are mediated by RGS4.
Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 4 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. Regulator of G protein signaling 4 protein is 37% identical to RGS1 and 97% identical to rat Rgs4. This protein negatively regulate signaling upstream or at the level of the heterotrimeric G protein and is localized in the cytoplasm. Alternatively spliced transcript variants have been found for this gene.
schizophrenia disorder 9
, regulator of G-protein signalling 4