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conserved protein interaction interface on the type 5 G protein beta subunit controls proteolytic stability and activity of R7 family regulator of G protein signaling proteins.
Stimulation of the ERK (show EPHB2 ELISA Kits) pathway in Gnb5 (show GNB5 ELISA Kits)(-/-) cells by epidermal growth factor (show EGF ELISA Kits) restored M3R (show CHRM3 ELISA Kits)-stimulated insulin (show INS ELISA Kits) release to near normal levels. Identification of the novel role of Gbeta5 (show GNB5 ELISA Kits)-R7 in insulin (show INS ELISA Kits) secretion may lead to a new therapeutic approach for improving pancreatic beta-cell function
This study identifies RGS7 as a novel regulator of Mu Opioid Receptor (show OPRM1 ELISA Kits) signaling by dissecting its circuit specific actions and pinpointing its role in regulating morphine reward by controlling the activity of nucleus accumbens neurons.
R7-binding protein (show RGS7BP ELISA Kits) had a strong inhibitory effect on homo-oligomerization of RGS7.
Association with the plasma membrane is sufficient for potentiating catalytic activity of RGS7 and RGS9-2 (show RGS ELISA Kits) proteins.
results demonstrate a novel role of RGS7 in hippocampal synaptic plasticity and memory formation
GPR158 is an essential regulator of RGS7 in the native nervous system with a critical role in controlling its expression, membrane localization, and catalytic activity
Expression of the Gbeta5 (show GNB5 ELISA Kits)/R7-RGS (show PITX2 ELISA Kits) protein complex in pituitary and pancreatic islet cells.
This study demonistrated that the subcellular localization of RGS7 in neurons and found that a significant fraction is present in cytoplasmic puncta.
RGS7 and RGS11 (show RGS11 ELISA Kits) are the key GTPase (show RACGAP1 ELISA Kits) accelerating proteins in the mGluR6 (show GRM6 ELISA Kits) pathway of retinal rod ON bipolar cells that set the sensitivity and time course of light-evoked responses.
Defective retinal depolarizing bipolar cells in regulators of G protein signaling (RGS) 7 and 11 double null mice.
Data (including data from studies using transgenic mice) suggest that R7BP (show RGS7BP ELISA Kits)-RGS7 heterotrimers interact with Galpha13 to augment signaling pathways in neurons that regulate neurite morphogenesis. (R7BP (show RGS7BP ELISA Kits) = RGS7 family binding protein; RGS7 = regulator of G-protein signaling 7 protein; Galpha13 = GTP-binding protein alpha subunit (show POLG ELISA Kits) 13)
Fine mapping of the uterine leiomyoma locus on 1q43 close to a lncRNA in the RGS7-FH interval
the GAP activity of RGS9-2 (show RGS ELISA Kits) showed a strong receptor preference for D2R (show DRD2 ELISA Kits) over MOR (show OPRM1 ELISA Kits). Finally, RGS7 displayed an four times greater GAP activity relative to RGS9-2 (show RGS ELISA Kits).
Gi/o signaling and the palmitoyltransferase DHHC2 (show ZDHHC2 ELISA Kits) regulate palmitate cycling and shuttling of RGS7 family-binding protein.
tumor necrosis factor-alpha (show TNF ELISA Kits) regulates the interaction of RGS7 with 14-3-3 (show YWHAQ ELISA Kits)
could play a role in synaptic vesicle exocytosis through its interaction with snapin (show SNAPIN ELISA Kits)
Galpha (show SUCLG1 ELISA Kits)-regulated plasma membrane localization and palmitoylation of RGS7.
cytoplasmic RGS7*Gbeta5 (show GNB5 ELISA Kits)*R7BP (show RGS7BP ELISA Kits) heterotrimers and RGS7*Gbeta5 (show GNB5 ELISA Kits) heterodimers are equivalently inefficient regulators of G protein-coupled receptor (show ADRA1A ELISA Kits) signaling relative to plasma membrane-bound heterotrimers bearing palmitoylated R7BP (show RGS7BP ELISA Kits).
The DEP (show ZDHHC21 ELISA Kits) domain of RGS7 can directly bind to the third intracellular loop of the M3R (show CHRM4 ELISA Kits) and attenuate receptor-induced Ca2 (show CA2 ELISA Kits)+ mobilization in a M3 subtype-selective manner.
acts as a GTPase activating protein; regulates activation and deactivation kinetics of G-protein coupled inward rectifier K+ channel; binds Galphao; Galphai3, and Galphaz
regulator of G-protein signalling 7
, regulator of G-protein signaling 7
, Regulator of G-protein signaling 7 (RGS7)
, regulator of G-protein signaling RGS7