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The rxfp1 expression pattern in Danio rerio embryos is very similar to that reported in the adult mammalian brain, suggesting a pivotal role of this receptor in the neurophysiology processes already at very early developmental stages.
Binding of relaxin to RXFP1 recruits G proteins with subsequent activation of adenylyl cyclase and elevation of cAMP.
The decreased expression of the endometrial RLX (show RLN1 Proteins) receptor in women with implantation failures, both in vitro fertilization failure and recurrent pregnancy loss, suggests that RLX (show RLN1 Proteins) may play a crucial role in the structural and functional changes of the endometrium during the window of implantation.
Hormone receptor (show NR4A1 Proteins) expression was concentrated in the fibroblasts, and RXFP1 was also evident in blood vessels and nerves
The complex binding mode of the peptide hormone H2 relaxin to its receptor RXFP1 has been deciphered.
RXFP1 gene expression was dysregulated in the anterior cingulate of bipolar patients.
H2 relaxin amide is fully active at the relaxin receptor RXFP1 and thus dimerization is not required for biological activity.
Synthetic covalently linked dimeric form of H2 relaxin retains native RXFP1 activity and has improved in vitro serum stability.
Using cells stably expressing RXFP1, we found that relaxin regulation of PPARgamma activity requires accumulation of cAMP and subsequent activation of cAMP-dependent protein kinase (PKA).
RXFP-1 receptors are present at the ligament, cartilage, and synovium of the TM joint, indicating that it is a potential target for relaxin. This suggests that circulating relaxin may impact joint stability.
To create a tool to investigate the low-affinity interaction, a protein scaffold system displaying exoloops 1 and 2 from RXFP1 was designed.
No differences were found in RXFP1 expression related to aging.
Colonic tissue expresses RXFP1 in smooth muscle cells of the muscular wall and in neurons of the myenteric plexus.
relaxin/RXFP1 signaling in smooth muscle cells is important for normal collagen turnover and relaxation of the pubic symphysis during pregnancy
Rxfp1, Rxfp2 (show RXFP2 Proteins), and Nr3c1 (show NR3C1 Proteins) mRNAs were expressed on the developing maxilla and mandible, Meckel's cartilage, tongue, and tooth primordia between mouse embryonic days 13.5-18.5.
maternal exposure to simazine causes disturbed relaxin signaling pathway and testicular dysfunction
H3 relaxin exerts antifibrotic actions via RXFP1 receptor
The downregulation of RXFP1 resulted in significant decrease in metastasis rate in PC3 (show BTG2 Proteins) tumors.
Rxfp1 acts in an autocrine and/or paracrine fashion upstream of PCDHY (show PCDH11Y Proteins) in regulating increased canonical Wnt (show WNT2 Proteins) signaling in prostate cancer.
neither Insl3 (show INSL3 Proteins) nor Lgr8 (show RXFP2 Proteins) contribute to the RLN (show RLN1 Proteins) signaling pathway; Insl3 (show INSL3 Proteins)/Lgr8 (show RXFP2 Proteins) and Rln1 (show RLN1 Proteins)/Lgr7 actions do not overlap in vivo
mouse and rat LGR7 are the relaxin receptors in these species
This gene encodes a member of the leucine-rich repeat-containing subgroup of the G protein-coupled 7-transmembrane receptor superfamily. The encoded protein plays a critical role in sperm motility, pregnancy and parturition as a receptor for the protein hormone relaxin. Decreased expression of this gene may play a role in endometriosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
leucine-rich repeat-containing G protein-coupled receptor 7
, relaxin/insulin-like family peptide receptor 1
, relaxin receptor 1-like
, relaxin receptor 1
, leucine-rich repeat-containing 7
, leucine-rich repeat-containing G-protein coupled receptor 7
, relaxin family peptide receptor 1
, relaxin/insulin-like family peptide receptor 2