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Submit your validation data for this product and get a full refund. I want to validate this productRelevance Score | ABIN | Application | Conjugate | Host | Isotype | Epitope | Supplier | Clonality | References | Details |
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18.811565 | ABIN2482996 | ICC IF IHC WB | FITC | Mouse | IgG1 | AA 1548-1582, C-Term | Log in to see | S289-16 | 0 | |
18.811565 | ABIN2482989 | ICC IF IHC WB | Atto 633 | Mouse | IgG1 | AA 1548-1582, C-Term | Log in to see | S289-16 | 0 | |
18.811565 | ABIN2482987 | ICC IF IHC WB | Atto 565 | Mouse | IgG1 | AA 1548-1582, C-Term | Log in to see | S289-16 | 0 | |
18.811565 | ABIN2482991 | ICC IF IHC WB | Atto 680 | Mouse | IgG1 | AA 1548-1582, C-Term | Log in to see | S289-16 | 0 | |
18.811565 | ABIN2482997 | ICC IF IHC WB | HRP | Mouse | IgG1 | AA 1548-1582, C-Term | Log in to see | S289-16 | 0 | |
18.811565 | ABIN2482999 | ICC IF IHC WB | PerCP | Mouse | IgG1 | AA 1548-1582, C-Term | Log in to see | S289-16 | 0 | |
18.811565 | ABIN2482988 | ICC IF IHC WB | Atto 594 | Mouse | IgG1 | AA 1548-1582, C-Term | Log in to see | S289-16 | 0 | |
18.811565 | ABIN2482998 | ICC IF IHC WB | PE-Atto 594 | Mouse | IgG1 | AA 1548-1582, C-Term | Log in to see | S289-16 | 0 | |
18.811565 | ABIN2482993 | ICC IF IHC WB | Alkaline Phosphatase (AP) | Mouse | IgG1 | AA 1548-1582, C-Term | Log in to see | S289-16 | 0 | |
18.811565 | ABIN2482994 | ICC IF IHC WB | APC | Mouse | IgG1 | AA 1548-1582, C-Term | Log in to see | S289-16 | 0 | |
18.811565 | ABIN2482986 | ICC IF IHC WB | Atto 488 | Mouse | IgG1 | AA 1548-1582, C-Term | Log in to see | S289-16 | 0 | |
18.811565 | ABIN2482990 | ICC IF IHC WB | Atto 655 | Mouse | IgG1 | AA 1548-1582, C-Term | Log in to see | S289-16 | 0 | |
18.811565 | ABIN2482992 | ICC IF IHC WB | Atto 700 | Mouse | IgG1 | AA 1548-1582, C-Term | Log in to see | S289-16 | 0 | |
18.811565 | ABIN2482995 | ICC IF IHC WB | Biotin | Mouse | IgG1 | AA 1548-1582, C-Term | Log in to see | S289-16 | 0 | |
18.811565 | ABIN2483000 | ICC IF IHC WB | PE | Mouse | IgG1 | AA 1548-1582, C-Term | Log in to see | S289-16 | 0 | |
18.811565 | ABIN2482985 | ICC IF IHC WB | Atto 390 | Mouse | IgG1 | AA 1548-1582, C-Term | Log in to see | S289-16 | 0 | |
18.811565 | ABIN2483001 | ICC IF IHC WB | Streptavidin | Mouse | IgG1 | AA 1548-1582, C-Term | Log in to see | S289-16 | 0 | |
-1.9515104 | ABIN5079903 | ICC IF IHC WB | Mouse | IgG1 | AA 1548-1582 | Log in to see | S289-16 | 0 | ||
-12.758193 | ABIN6245652 | ICC IF IHC | Janelia Fluor® 549 | Mouse | IgG1 | AA 1548-1582, C-Term | Log in to see | S289-16 | 0 | |
-12.758193 | ABIN6245653 | ICC IF IHC | Janelia Fluor® 646 | Mouse | IgG1 | AA 1548-1582, C-Term | Log in to see | S289-16 | 0 |
General |
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Antigen | ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 8 (ABCC8) Antibodies |
Epitope | AA 1548-1582, C-Term Alternatives |
Reactivity | Hamster, Human, Mouse (Murine), Rat (Rattus) Alternatives |
Host | Mouse Alternatives |
Clonality (Clone) | |
Conjugate | This ABCC8 antibody is un-conjugated Alternatives |
Application |
Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blotting (WB)
Alternatives
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2 references available |
Supplier | Log in to see |
Product Details anti-ABCC8 AntibodyTarget Details ABCC8 Application Details Handling References for anti-ABCC8 antibody (ABIN1027723) Images |
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Specificity | Detects ~160 kDa. Does not cross-react with SUR2B. |
Purification | Protein G Purified |
Immunogen | Fusion protein amino acids 1548-1582 (cytoplasmic C-terminus) of rat SUR1 |
Clone | S289-16 |
Isotype | IgG1 |
Plasmids, Primers & others | |
Target Details ABCC8Product Details anti-ABCC8 Antibody Application Details Handling References for anti-ABCC8 antibody (ABIN1027723) Images back to top |
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Antigen | |
Alternative Name | SUR1 (ABCC8 Antibody Abstract) |
Background | Sulfonylurea receptors (SUR) are membrane proteins which are the molecular targets of the sulfonylurea class of anti-diabetic drugs whose mechanism of action is to promote insulin release from pancreatic beta cells. More specifically, SUR proteins are subunits of the inward-rectifier potassium ion channels Kir6.x (6.1 and 6.2) (1). The association of four Kir6.x and four SUR subunits form an ion conducting channel commonly referred to as the KATP channel. The primary function of the sulfonylurea receptor is to sense intracellular levels of the nucleotides ATP and ADP and in response facilitate the open or closing its associated Kir6.x potassium channel. Hence the KATP channel monitors the energy balance within the cell (2). |
Gene ID | 25559 |
NCBI Accession | NP_037171 |
UniProt | Q09429 |
Pathways | Negative Regulation of Hormone Secretion |
Application DetailsProduct Details anti-ABCC8 Antibody Target Details ABCC8 Handling References for anti-ABCC8 antibody (ABIN1027723) Images back to top |
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Application Notes |
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Comment |
1 μg/ml of SMC-409 was sufficient for detection of SUR1 in 20 μg of mouse brain membrane lysate and assayed by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody. |
Restrictions | For Research Use only |
HandlingProduct Details anti-ABCC8 Antibody Target Details ABCC8 Application Details References for anti-ABCC8 antibody (ABIN1027723) Images back to top |
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Format | Liquid |
Concentration | 1 mg/mL |
Buffer | PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide |
Preservative | Sodium azide |
Precaution of Use | This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only. |
Storage | -20 °C |
References for anti-ABCC8 antibody (ABIN1027723)Product Details anti-ABCC8 Antibody Target Details ABCC8 Application Details Handling Images back to top |
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Background publications |
Nichols: "KATP channels as molecular sensors of cellular metabolism." in: Nature, Vol. 440, Issue 7083, pp. 470-6, 2006 Campbell, Sansom, Ashcroft: "Potassium channel regulation." in: EMBO reports, Vol. 4, Issue 11, pp. 1038-42, 2003 |
ImagesProduct Details anti-ABCC8 Antibody Target Details ABCC8 Application Details Handling References for anti-ABCC8 antibody (ABIN1027723) back to top |
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Supplier Images |