anti-Human ABCC8 antibody for Western Blotting

Recommended ABCC8 Antibody (supplied by: Log in to see )

Antigen
ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 8 (ABCC8) Antibodies
  • ABC36
  • HHF1
  • HI
  • HRINS
  • MRP8
  • PHHI
  • SUR
  • SUR1
  • SUR1delta2
  • TNDM2
  • D930031B21Rik
  • Sur
  • Sur1
  • ATP binding cassette subfamily C member 8
  • ATP-binding cassette, sub-family C (CFTR/MRP), member 8
  • ABCC8
  • Abcc8
Epitope
N-Term
72
67
14
4
4
3
2
2
1
1
1
1
1
Reactivity
Cow (Bovine), Dog (Canine), Human, Mouse (Murine), Pig (Porcine), Rabbit, Rat (Rattus), Zebrafish (Danio rerio)
105
96
84
71
3
2
2
1
1
1
1
1
Host
Rabbit
96
26
17
Clonality
Polyclonal
Conjugate
This ABCC8 antibody is un-conjugated
9
9
7
6
5
4
4
3
3
3
3
3
3
3
3
3
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (IHC), Western Blotting (WB)
126
92
65
45
34
21
9
3
2
2
1
1
1
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Catalog No. ABIN2781496
$ 289.00
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
2.8412423 ABIN4948191 ELISA WB Mouse IgG2a kappa AA 611-711 Log in to see 3G5 5
2.8412423 ABIN2464822 ELISA WB Goat C-Term Log in to see Polyclonal 0
2.8412423 ABIN1027723 ICC IF IHC WB Mouse IgG1 AA 1548-1582, C-Term Log in to see S289-16 2
2.8412423 ABIN2482996 ICC IF IHC WB FITC Mouse IgG1 AA 1548-1582, C-Term Log in to see S289-16 0
2.8412423 ABIN2482998 ICC IF IHC WB PE-Atto 594 Mouse IgG1 AA 1548-1582, C-Term Log in to see S289-16 0
2.8412423 ABIN2482994 ICC IF IHC WB APC Mouse IgG1 AA 1548-1582, C-Term Log in to see S289-16 0
2.8412423 ABIN2482993 ICC IF IHC WB Alkaline Phosphatase (AP) Mouse IgG1 AA 1548-1582, C-Term Log in to see S289-16 0
2.8412423 ABIN2482995 ICC IF IHC WB Biotin Mouse IgG1 AA 1548-1582, C-Term Log in to see S289-16 0
2.8412423 ABIN2482990 ICC IF IHC WB Atto 655 Mouse IgG1 AA 1548-1582, C-Term Log in to see S289-16 0
2.8412423 ABIN2482989 ICC IF IHC WB Atto 633 Mouse IgG1 AA 1548-1582, C-Term Log in to see S289-16 0
2.8412423 ABIN2482987 ICC IF IHC WB Atto 565 Mouse IgG1 AA 1548-1582, C-Term Log in to see S289-16 0
2.8412423 ABIN2482992 ICC IF IHC WB Atto 700 Mouse IgG1 AA 1548-1582, C-Term Log in to see S289-16 0
2.8412423 ABIN2482986 ICC IF IHC WB Atto 488 Mouse IgG1 AA 1548-1582, C-Term Log in to see S289-16 0
2.8412423 ABIN2482991 ICC IF IHC WB Atto 680 Mouse IgG1 AA 1548-1582, C-Term Log in to see S289-16 0
2.8412423 ABIN2482988 ICC IF IHC WB Atto 594 Mouse IgG1 AA 1548-1582, C-Term Log in to see S289-16 0
2.8412423 ABIN2482985 ICC IF IHC WB Atto 390 Mouse IgG1 AA 1548-1582, C-Term Log in to see S289-16 0
2.8412423 ABIN2482997 ICC IF IHC WB HRP Mouse IgG1 AA 1548-1582, C-Term Log in to see S289-16 0
2.8412423 ABIN2482999 ICC IF IHC WB PerCP Mouse IgG1 AA 1548-1582, C-Term Log in to see S289-16 0
2.8412423 ABIN2483001 ICC IF IHC WB Streptavidin Mouse IgG1 AA 1548-1582, C-Term Log in to see S289-16 0
2.8412423 ABIN2483000 ICC IF IHC WB PE Mouse IgG1 AA 1548-1582, C-Term Log in to see S289-16 0

General

Antigen ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 8 (ABCC8) Antibodies
Epitope N-Term
(72), (67), (14), (4), (4), (3), (2), (2), (1), (1), (1), (1), (1)
Reactivity Cow (Bovine), Dog (Canine), Human, Mouse (Murine), Pig (Porcine), Rabbit, Rat (Rattus), Zebrafish (Danio rerio)
(105), (96), (84), (71), (3), (2), (2), (1), (1), (1), (1), (1)
Host Rabbit
(96), (26), (17)
Clonality
Polyclonal
Conjugate This ABCC8 antibody is un-conjugated
(9), (9), (7), (6), (5), (4), (4), (3), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Immunohistochemistry (IHC), Western Blotting (WB)
(126), (92), (65), (45), (34), (21), (9), (3), (2), (2), (1), (1), (1)
Pubmed 2 references available
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Product Details anti-ABCC8 Antibody

Target Details ABCC8 Application Details Handling References for anti-ABCC8 antibody (ABIN2781496) Images
Blocking Peptide Blocking peptide for this product available: ABIN972735
Sequence PLAFCGSENH SAAYRVDQGV LNNGCFVDAL NVVPHVFLLF ITFPILFIGW
Predicted Reactivity Cow: 100%, Dog: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 85%
Characteristics This is a rabbit polyclonal antibody against ABCC8. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Immunogen The immunogen is a synthetic peptide directed towards the N terminal region of human ABCC8
Plasmids, Primers & others

Target Details ABCC8

Product Details anti-ABCC8 Antibody Application Details Handling References for anti-ABCC8 antibody (ABIN2781496) Images back to top
Antigen
Alternative Name ABCC8 (ABCC8 Antibody Abstract)
Background ABCC8 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). ABCC8 is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a modulator of ATP-sensitive potassium channels and insulin release. Mutations and deficiencies in this protein have been observed in patients with hyperinsulinemic hypoglycemia of infancy, an autosomal recessive disorder of unregulated and high insulin secretion. Mutations have also been associated with non-insulin-dependent diabetes mellitus type II, an autosomal dominant disease of defective insulin secretion.The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a modulator of ATP-sensitive potassium channels and insulin release. Mutations and deficiencies in this protein have been observed in patients with hyperinsulinemic hypoglycemia of infancy, an autosomal recessive disorder of unregulated and high insulin secretion. Mutations have also been associated with non-insulin-dependent diabetes mellitus type II, an autosomal dominant disease of defective insulin secretion. Alternative splicing of this gene has been observed, however, the transcript variants have not been fully described. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: ABC36, HHF1, HI, HRINS, MRP8, PHHI, SUR, SUR1, TNDM2, SUR1delta2
Protein Interaction Partner: ENSA, KCNJ11, CRYBB1, KCNJ8, RAPGEF4,
Protein Size: 1581
Molecular Weight 177 kDa
Gene ID 6833
NCBI Accession NM_000352, NP_000343
UniProt Q09428
Pathways Negative Regulation of Hormone Secretion

Application Details

Product Details anti-ABCC8 Antibody Target Details ABCC8 Handling References for anti-ABCC8 antibody (ABIN2781496) Images back to top
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 1581 AA

Restrictions For Research Use only

Handling

Product Details anti-ABCC8 Antibody Target Details ABCC8 Application Details References for anti-ABCC8 antibody (ABIN2781496) Images back to top
Format Liquid
Concentration Lot specific
Buffer Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-ABCC8 antibody (ABIN2781496)

Product Details anti-ABCC8 Antibody Target Details ABCC8 Application Details Handling Images back to top
Product cited in:

Němcová-Fürstová, Kopperová, Balušíková, Ehrlichová, Brynychová, Václavíková, Daniel, Souček, Kovář: "Characterization of acquired paclitaxel resistance of breast cancer cells and involvement of ABC transporters." in: Toxicology and applied pharmacology, Vol. 310, pp. 215-228, 2016

Background publications

Babenko: "A novel ABCC8 (SUR1)-dependent mechanism of metabolism-excitation uncoupling." in: The Journal of biological chemistry, Vol. 283, Issue 14, pp. 8778-82, 2008

Images

Product Details anti-ABCC8 Antibody Target Details ABCC8 Application Details Handling References for anti-ABCC8 antibody (ABIN2781496) back to top
Supplier Images
Immunohistochemistry (IHC) image for anti-ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 8 (ABCC8) (N-Term) antibody (ABIN2781496) anti-ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 8 (ABCC8) (N-Term) antibody
Western Blotting (WB) image for anti-ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 8 (ABCC8) (N-Term) antibody (ABIN2781496) WB Suggested Anti-ABCC8 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:62500 Posi...