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|Antigen||Anti-Mullerian Hormone (AMH) Antibodies|
|Reactivity||Human, Monkey, Mouse (Murine), Sheep (Ovine) Alternatives|
|Conjugate||This AMH antibody is un-conjugated Alternatives|
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
|2 references available|
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Product Details anti-AMH AntibodyTarget Details AMH Application Details Handling References for anti-AMH antibody (ABIN317404) Images
|Specificity||This antibody is specific for Human anti-Mullerian Hormone (AMH), originally classified as a foetal testicular hormone that inhibits Mullerian duct development. AMH is a member of the TGF beta superfamily. It is secreted as a homodimeric 140 kDa disulphide linked precursor that is cleaved to release the mature 30 kDa homodimer.|
|Cross-Reactivity (Details)||Species reactivity (tested):Human, Mouse, Sheep, Monkey|
|Characteristics||Synonyms: Muellerian-inhibiting factor, MIF, MIS, Muellerian-inhibiting substance|
|Immunogen||Synthetic peptide derived from Human AMH. Spleen cells from immunised T/O outbred mice were fused with cells of the SP2/0myeloma cell lineAA Sequence: VPTAYAGKLLISLSEERISAHHVPNMVATEC|
Target Details AMHProduct Details anti-AMH Antibody Application Details Handling References for anti-AMH antibody (ABIN317404) Images back to top
|Alternative Name||Anti-Muellerian Hormone / AMH (AMH Antibody Abstract)|
|Background||Anti Mullerian Hormone (AMH) is a member of the TGF beta superfamily. It is secreted as a homodimeric 140kD disulphide linked precursor that is cleaved to release the mature 30kD homodimer. Originally classified as a foetal testicular hormone that inhibits Mullerian duct development, AMH is expressed post natally by immature Sertoli cells, and to a lesser degree by granulosa cells. AMH plays a role in testicular differentiation and in the regulation of ovarian follicle growth.Synonyms: MIF, MIS, Muellerian-inhibiting factor, Muellerian-inhibiting substance|
|Pathways||Negative Regulation of Hormone Secretion|
Application DetailsProduct Details anti-AMH Antibody Target Details AMH Handling References for anti-AMH antibody (ABIN317404) Images back to top
Western blot. Immunohistology on Paraffin Sections.1/20-1/40 (Requires antigen retrieval using heattreatment methods prior to staining, Sodium Citrate buffer pH 6.0 is recommended for thispurpose). Recommended Positive Control: Ovary Tissue.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-AMH Antibody Target Details AMH Application Details References for anti-AMH antibody (ABIN317404) Images back to top
|Buffer||0.09 % Sodium Azide|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Storage||4 °C/-20 °C|
Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
|Expiry Date||12 months|
References for anti-AMH antibody (ABIN317404)Product Details anti-AMH Antibody Target Details AMH Application Details Handling Images back to top
Gruijters, Visser, Durlinger, Themmen: "Anti-Müllerian hormone and its role in ovarian function." in: Molecular and cellular endocrinology, Vol. 211, Issue 1-2, pp. 85-90, 2003
Tabibzadeh: "The signals and molecular pathways involved in human menstruation, a unique process of tissue destruction and remodelling." in: Molecular human reproduction, Vol. 2, Issue 2, pp. 77-92, 1997
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