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General |
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Antigen | Chromogranin A (CHGA) Antibodies |
Reactivity | Buffalo (Bubalus), Chicken, Cow (Bovine), Dolphin, Gerbil, Human, Mouse (Murine), Pig (Porcine), Rat (Rattus), Sea lion (Otariidae), Sheep (Ovine), Sunda Pangolin (Manis javanica) Alternatives |
Host | Rabbit Alternatives |
Clonality | |
Conjugate | Un-conjugated Alternatives |
Application |
Immunoelectron Microscopy (IEM), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC)
Alternatives
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36 references available |
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Cross-Reactivity | Mammalian |
Characteristics | The antibody has a proven strong immunofluorescent staining at a 1/200-1/400 dilution, and a 4+ Biotin-Streptavidin/HRP staining at a 1/500-1/1000 dilution, in rat adrenal medulla and rat stomach. |
Purification | Whole Serum |
Immunogen | porcine Chromogranin A |
Isotype | IgG |
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Antigen | |
Alternative Name | Chromogranin A (CHGA Antibody Abstract) |
Background |
Other Names: Pituitary secretory protein I, CgA, chromogranin A (parathyroid secretory protein 1) |
Gene ID | 397540 |
Pathways | Negative Regulation of Hormone Secretion, cAMP Metabolic Process, Regulation of G-Protein Coupled Receptor Protein Signaling |
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Restrictions | For Research Use only |
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Format | Liquid |
Buffer | Contains ≤ 0.09 % sodium azide |
Preservative | Sodium azide |
Precaution of Use | This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only. |
Storage | 4 °C/-20 °C |
Storage Comment | After reconstitution, use immediately or refrigerate at 2 - 8 °C up to 2 days. For long-term storage aliquot antibody and freeze at -15 °C or lower. Avoid repeated freeze/thaw cycles. |
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Product cited in: |
Fossmark, Sørdal, Bakkelund, Nordrum, Waldum: "The effects of unilateral truncal vagotomy on gastric carcinogenesis in hypergastrinemic Japanese female cotton rats." in: Regulatory peptides, Vol. 184, pp. 62-7, 2013 Sørdal, Waldum, Nordrum, Boyce, Bergh, Munkvold, Qvigstad: "The gastrin receptor antagonist netazepide (YF476) prevents oxyntic mucosal inflammation induced by Helicobacter pylori infection in Mongolian gerbils." in: Helicobacter, Vol. 18, Issue 6, pp. 397-405, 2013 Gonzalez, Williamson, Piedrahita, Blikslager, Magness: "Cell lineage identification and stem cell culture in a porcine model for the study of intestinal epithelial regeneration." in: PLoS ONE, Vol. 8, Issue 6, pp. e66465, 2013 Sandhu, Wu, Nabi, Rastegar, Kung, Mai, Ding: "Loss of HLTF function promotes intestinal carcinogenesis." in: Molecular cancer, Vol. 11, pp. 18, 2012 Russo, Gatta, De Girolamo, Cozzi, Giurisato, Lucini, Varricchio: "Expression and immunohistochemical detection of leptin-like peptide in the gastrointestinal tract of the South American sea lion (Otaria flavescens) and the bottlenose dolphin (Tursiops truncatus)." in: Anatomical record (Hoboken, N.J. : 2007), Vol. 295, Issue 9, pp. 1482-93, 2012 Fre, Hannezo, Sale, Huyghe, Lafkas, Kissel, Louvi, Greve, Louvard, Artavanis-Tsakonas: "Notch lineages and activity in intestinal stem cells determined by a new set of knock-in mice." in: PLoS ONE, Vol. 6, Issue 10, pp. e25785, 2011 Ramalingam, Daughtridge, Johnston, Gracz, Magness: "Distinct levels of Sox9 expression mark colon epithelial stem cells that form colonoids in culture." in: American journal of physiology. Gastrointestinal and liver physiology, Vol. 302, Issue 1, pp. G10-20, 2011 Fjeldbo, Bakke, Erlandsen, Holmseth, Lægreid, Sandvik, Thommesen, Bruland: "Gastrin upregulates the prosurvival factor secretory clusterin in adenocarcinoma cells and in oxyntic mucosa of hypergastrinemic rats." in: American journal of physiology. Gastrointestinal and liver physiology, Vol. 302, Issue 1, pp. G21-33, 2011 Formeister, Sionas, Lorance, Barkley, Lee, Magness: "Distinct SOX9 levels differentially mark stem/progenitor populations and enteroendocrine cells of the small intestine epithelium." in: American journal of physiology. Gastrointestinal and liver physiology, Vol. 296, Issue 5, pp. G1108-18, 2009 Kokrashvili, Rodriguez, Yevshayeva, Zhou, Margolskee, Mosinger: "Release of endogenous opioids from duodenal enteroendocrine cells requires Trpm5." in: Gastroenterology, Vol. 137, Issue 2, pp. 598-606, 606.e1-2, 2009 Russo, Pavone, Tafuri, Avallone, Staiano, Vittoria: "Expression of orexin A and its receptor 1 in the bovine urethroprostatic complex." in: Anatomical record (Hoboken, N.J. : 2007), Vol. 291, Issue 2, pp. 169-74, 2008 Crissey, Guo, Fogt, Li, Katz, Silberg, Suh, Lynch: "The homeodomain transcription factor Cdx1 does not behave as an oncogene in normal mouse intestine." in: Neoplasia (New York, N.Y.), Vol. 10, Issue 1, pp. 8-19, 2008 Hamza, Higgins, Ruyechan: "Herpes simplex virus type-1 latency-associated transcript-induced immunoreactivity of substance P in trigeminal neurons is reversed by bone morphogenetic protein-7." in: Neuroscience letters, Vol. 413, Issue 1, pp. 31-5, 2007 Bastide, Darido, Pannequin, Kist, Robine, Marty-Double, Bibeau, Scherer, Joubert, Hollande, Blache, Jay: "Sox9 regulates cell proliferation and is required for Paneth cell differentiation in the intestinal epithelium." in: The Journal of cell biology, Vol. 178, Issue 4, pp. 635-48, 2007 Yuan, Liu, Liu, Cui: "Chromogranin A-positive tumor cells in human esophageal squamous cell carcinomas." in: Pathology oncology research : POR, Vol. 13, Issue 4, pp. 321-5, 2007 Wang, Ray, Hinds, Leiter: "The retinoblastoma protein, RB, is required for gastrointestinal endocrine cells to exit the cell cycle, but not for hormone expression." in: Developmental biology, Vol. 311, Issue 2, pp. 478-86, 2007 Takaishi, Cui, Frederick, Carlson, Houghton, Varro, Dockray, Ge, Whary, Rogers, Fox, Wang: "Synergistic inhibitory effects of gastrin and histamine receptor antagonists on Helicobacter-induced gastric cancer." in: Gastroenterology, Vol. 128, Issue 7, pp. 1965-83, 2005 Nisa, Kitamura, Sasaki, Agungpriyono, Choliq, Budipitojo, Yamada, Sigit: "Immunohistochemical study on the distribution and relative frequency of endocrine cells in the stomach of the Malayan Pangolin, Manis javanica." in: Anatomia, histologia, embryologia, Vol. 34, Issue 6, pp. 373-8, 2005 Cui, Koh, Chen, Zhao, Takaishi, Dockray, Varro, Rogers, Fox, Wang: "Overexpression of glycine-extended gastrin inhibits parietal cell loss and atrophy in the mouse stomach." in: Cancer research, Vol. 64, Issue 22, pp. 8160-6, 2004 Madison, Braunstein, Kuizon, Portman, Qiao, Gumucio: "Epithelial hedgehog signals pattern the intestinal crypt-villus axis." in: Development (Cambridge, England), Vol. 132, Issue 2, pp. 279-89, 2004 |
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