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Study indicates that chga may play an important role in nervous system development during the early embryonic stages.
CgA (show CGA Proteins) is an important regulator for coordination of mitochondrial dynamics, secretory vesicular quanta and glucose-stimulated insulin (show INS Proteins) secretion for optimal secretory functioning of beta-cells, suggesting a strong, CgA (show CGA Proteins)-dependent positive link between mitochondrial fusion and glucose-stimulated insulin (show INS Proteins) secretion
Increased myocardial CgA (show CGA Proteins) glycosylation and impaired CgA (show CGA Proteins) processing to catestatin in heart failure be considered detrimental because CST (show CORT Proteins) reduces diastolic Ca2 (show CA2 Proteins)+ leak via direct CaMKIIdelta inhibition.
performance of CgA (show CGA Proteins)-deficient Chga-KO mice in treadmill exercise was impaired. CgA (show CGA Proteins) deficiency renders the muscle energy deficient, impairs performance in treadmill exercise and prevents regeneration after exercise-induced tissue damage.
dilated mitochondrial cristae, endoplasmic reticulum and Golgi complex, as well as increased synaptic mitochondria, synaptic vesicles and glycogen (show GYS1 Proteins) granules in Chga-knockout mice compared to WT mice.
the presence of ChgA and subsequent activation of ChgA-reactive T cells are essential for the initiation and development of autoimmune diabetes in NOD mice.
Studied leptin (show LEP Proteins) and CST (show CORT Proteins) modulation of SGLT1 (show SLC5A1 Proteins) expression in hyperleptinemic type 2 diabetic mice.
N-terminal additions to the WE14 peptide of chromogranin A create strong autoantigen agonists in type 1 diabetes.
Data indicate that T-cell receptors that react to chromogranin A (ChgA) and islet amyloid polypeptide (show IAPP Proteins) precursor (IAPP (show IAPP Proteins)) autoantigens were impaired when the thymic stromal cells lacked thymus-specific serine protease (TSSP (show PRSS16 Proteins)).
the important roles of CgA and CgB in glucose and cardiovascular homeostasis. This study also unveils the existence of direct implications of Cgs in the control of behaviour and mood.
Chromogranin A (10-19) and chromogranin A (43-52) were identified as antigens for autoreactive CD8 (show CD8A Proteins)(+) T cells in NOD.beta2m(null).HHD (show ATP2C1 Proteins) mice.
Results suggest that severe atopic dermatitis is associated with higher stress levels. Simple salivary CgA (show CGA Proteins) measurements may be useful as an objective assessment of patient stress.
cardiac atria express but do not secrete CgA (show CGA Proteins) into circulation in patients with atrial disease
These results suggest that circulating full-length CgA (show CGA Proteins) is an important inhibitor of angiogenesis and tumor growth, and that cleavage of its C-terminal region markedly reduces its activity. Pathophysiological changes in CgA (show CGA Proteins) blood levels and/or its fragmentation might regulate disease progression in cancer patients.
Results show that chronic lymphocytic leukemia (CLL) patients had increased plasma levels of chromogranin A (CgA), compared to normal subjects, particularly those >70-year-old or those treated with proton pump inhibitors.
The authors show that CHGA-415 T/C polymorphism is an independent risk factor of poor prognosis in critically ill patients
Concurrent increases in plasma BNP (B-type natriuretic peptide (show BNP Proteins)) and CST (show GAL3ST1 Proteins) levels predicted the highest risk for both all-cause and cardiac deaths in chronic heart failure patients.
Full-length CgA (show CGA Proteins) is an independent indicator of atherosclerotic plaques in carotid artery stenosis.
Even a single baseline measurement of CgA (show CGA Proteins) can be useful in establishing prognosis in this group, if this parameter exceeds its upper normal limit more than tenfold.
Compared with chromogranin A, chromogranin B (show CHGB Proteins) may be more useful during proton pump inhibitor treatment and can detect tumors without liver metastases.
Salivary impairments and high levels of CHGA are associated with T2DM patients. In addition, CGHA polymorphisms might be associated with salivary gland hypofunction and higher salivary CHGA production in T2DM patients. This could be a significant insight to establish a role for salivary CHGA as a potential clinical biomarker to T2DM.
High pancreastatin levels are significantly associated with neuroendocrine tumors.
No circadian pattern was detected for salivary CgA in either spring or autumn, and there were no significant effects of gender or age. However, mean salivary CgA concentrations were significantly higher in the pigs sampled in autumn, compared to spring.
expression and localization of chromogranin A (CgA), chromogranin B (CgB (show CHGB Proteins)), synaptophysin (show SYP Proteins), and insulin (show INS Proteins) were ultrastructurally studied with the immunogold technique in porcine and human pancreatic islet neuroendocrine cells
Vasoconstriction-Inhibiting Factor (VIF (show BTG1 Proteins)), a degradation product of chromogranin A, is a vasoregulatory peptide that modulates the vasoconstrictive effects of angiotensin II by acting on the angiotensin II type 2 receptor (show AGTR2 Proteins).
chromogranin A has a role in the IP(3)-mediated Ca(2 (show CA2 Proteins)+) release mechanism of secretory granules
chromogranin A has a specific site in the N-terminal domain that can bind membrane lipids from different species
role of coupling with the inositol 1,4,5-trisphosphate receptor/Ca2 (show CA2 Proteins)+ channel (InsP3R (show ITPR1 Proteins))in the Ca2 (show CA2 Proteins)+-dependent ciliary movement
involvement of CGA (show CGA Proteins) with other components of the senile plaque
significant species differences in vasoactivity of the N-terminal domain of ChgA
determination of the subcellular distribution of chromogranins A and B in chromaffin cells; results suggest that chromogranins are at the center of intracellular Ca(2 (show CA2 Proteins)+) homeostasis in secretory cells
The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocrine cells. This gene product is a precursor to three biologically active peptides\; vasostatin, pancreastatin, and parastatin. These peptides act as autocrine or paracrine negative modulators of the neuroendocrine system. Other peptides, including chromostatin, beta-granin, WE-14 and GE-25, are also derived from the full-length protein. However, biological activities for these molecules have not been shown.
, chromogranin A
, betagranin (N-terminal fragment of chromogranin A)
, parathyroid secretory protein 1
, pituitary secretory protein I