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The expression of UCN, CRHR1, CRHR2 and CRHBP by immunohistochemistry, Western blot and reverse transcription with the polymerase chain reaction (RT-PCR) in the horse thyroid gland, was investigated
CRF2 signaling induces alterations in both the epithelium permeability and the differentiation of human colonic carcinoma cell lines.
Data show that corticotropin releasing hormone receptor 2 (Crhr2) protein is abundantly expressed in the heart, and plasma Ucn2 levels were higher in patients with heart failure compared to healthy controls, indicating that endogenous Crhr2 is associated with heart failure.
Taken together, our data indicate that sex shows significant interaction with genotype and Ucn1 during colitis. Human duodenal and colonic biopsies revealed that sex-specific differences exist in levels of CRF receptors and Ucn1 expression in patients with CD compared with the matched non-IBD subjects. To conclude, Ucn1 mediates sex-specific immune and cellular signaling responses via CRF2, emphasizing the need for inclus
In deep infiltrating endometriotic lesions, CRH (show CRH Proteins), Ucn and CRH-R2 mRNA levels were significantly higher than in ovarian endometrioma.
Endogenous CRF (show CRH Proteins) may be involved in the pathogenesis of ischemia/reperfusion-induced enteritis, possibly via the activation of peripheral CRF (show CRH Proteins) receptor 2
This study showed that two CRHR2 variants (rs4722999-C and rs12701020-C) in BPD subjects with sexual and physical abuse.
found associations between CRHR2 genotypes and haplotypes and negative emotion in IBS patients and controls
Wound healing and signal transducer and activator of transcription 3 activity were elevated in CRHR2-overexpressing cells after urocortin 2 and IL-6 treatment, suggesting advanced healing progression
This study demonstrated that CRF2 Receptor Deficiency Eliminates the Long-Lasting Vulnerability of Motivational States Induced by Opiate Withdrawal.
D1 and CRF2 alpha receptors are capable of heterodimerization in living cells. D1 /CRF2 alpha receptor heteromerization might account, at least in part, for the complex physiological interactions established between dopamine and CRH (show CRH Proteins).
CRFR2-expressing neurons within the posterior bed nucleus of the stria terminalis (pBNST) send dense inhibitory projections to other stress-related brain regions. Local CRFR2 activation by urocortin 3 (show UCN3 Proteins) depolarized the cells, increased the neuronal input resistance and increased firing of action potentials. Optogenetic activation of CRFR2 neurons in the pBNST decreased anxiety and attenuated stress responses.
Urocortin 2 (show UTS2 Proteins) acts on gonadotrophs expressing the corticotropin-releasing factor (show CRH Proteins) type 2 receptor, and inhibits the production of gonadotropins in the pituitary gonadotropic tumor cells.
Results indicate that corticotropin releasing hormone receptor 2 (Crhr2) is highly expressed in cardiomyocytes, and cardiomyocyte-specific deletion of Crhr2 protected mice from pressure overload-induced cardiac dysfunction.
findings collectively suggest that the MeA (show MEA1 Proteins) Ucn3 (show UCN3 Proteins)-CRF-R2 system modulates the ability of mice to cope with social challenges
Study suggests that selective CRF2 receptor agonists urocortin 2 (show UTS2 Proteins) and 3 could be used as a therapy in nicotine addiction.
Study demonstrated that CRF1 receptor (show CRHR1 Proteins)-deficiency prolongs whereas CRF2 receptor-deficiency shortens the duration of recognition memory deficits induced by morphine discontinuation, unraveling opposite roles for the two known CRF (show CRH Proteins) receptor subtypes in cognitive dysfunction associated with opiate withdrawal.
results indicate that long-term UVA eye irradiation led to increased gp91phox (show CYBB Proteins)-derived ROS (show ROS1 Proteins) in the brain and the increased expression of urocortin 2 (show UTS2 Proteins) and CRHR (show CRHR1 Proteins) type 2, resulting in photoaging; however, further studies are needed to confirm these findings
Crhr2(-/-) mice showed increased mortality in the dextran sodium sulfate healing protocol
the inhibitory effect of CRFR2 signaling on insulin (show INS Proteins) action is mediated by cAMP in a mammalian target of rapamycin (show FRAP1 Proteins)-dependent manner.
This study aims to investigate the cellular localization of CRF (show CRH Proteins) and UCNs in the ileum and to explore whether and how this cellular expression is altered in conditions of intestinal Schistosoma mansoni-induced inflammation.
These results suggest that a regulatory system exists in the bovine thyroid gland based on UCN, CRHR1 and CRHR2 and that UCN plays a role in the regulation of thyroid physiological functions through an autocrine/paracrine mechanism.
CRHR1 (show CRHR1 Proteins) and CRHR2 are expressed in the bovine adrenal gland.
CRFr1 (show CRHR1 Proteins) activation mediates intestinal mucosa barrier dysfunction and hypersecretion in early-weaned piglets, whereas CRFr2 activation may be responsible for novel protective properties in the porcine intestine in response to early life stress.
The protein encoded by this gene belongs to the G-protein coupled receptor 2 family, and the subfamily of corticotropin releasing hormone receptor. This receptor shows high affinity for corticotropin releasing hormone (CRH), and also binds CRH-related peptides such as urocortin. CRH is synthesized in the hypothalamus, and plays an important role in coordinating the endocrine, autonomic, and behavioral responses to stress and immune challenge. Studies in mice suggest that this receptor maybe involved in mediating cardiovascular homeostasis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
corticotropin releasing hormone receptor 2
, corticotropin-releasing factor receptor 2-like
, CRF2 receptor, beta isoform
, corticotropin-releasing factor receptor 2
, CRF 2 receptor
, corticotropin releasing factor receptor type 2 beta
, corticotropin-releasing factor 2
, corticotropin-releasing hormone receptor 2
, CRF-R 2
, CRH-R 2
, corticotrophin releasing hormone receptor 2
, corticotropin-releasing factor receptor subtype 2
, putative corticotropin-releasing hormone receptor type 2