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The expression of UCN, CRHR1, CRHR2 and CRHBP by immunohistochemistry, Western blot and reverse transcription with the polymerase chain reaction (RT-PCR) in the horse thyroid gland, was investigated
A non-coding CRHR2 SNP rs255105, a cis-eQTL for a downstream lincRNA AC005154.6, is associated with heroin addiction.
CRF2 signaling induces alterations in both the epithelium permeability and the differentiation of human colonic carcinoma cell lines.
Data show that corticotropin releasing hormone receptor 2 (Crhr2) protein is abundantly expressed in the heart, and plasma Ucn2 levels were higher in patients with heart failure compared to healthy controls, indicating that endogenous Crhr2 is associated with heart failure.
Taken together, our data indicate that sex shows significant interaction with genotype and Ucn1 during colitis. Human duodenal and colonic biopsies revealed that sex-specific differences exist in levels of CRF receptors and Ucn1 expression in patients with CD compared with the matched non-IBD subjects. To conclude, Ucn1 mediates sex-specific immune and cellular signaling responses via CRF2, emphasizing the need for inclus
In deep infiltrating endometriotic lesions, CRH, Ucn and CRH-R2 mRNA levels were significantly higher than in ovarian endometrioma.
Endogenous CRF may be involved in the pathogenesis of ischemia/reperfusion-induced enteritis, possibly via the activation of peripheral CRF receptor 2
This study showed that two CRHR2 variants (rs4722999-C and rs12701020-C) in BPD subjects with sexual and physical abuse.
found associations between CRHR2 genotypes and haplotypes and negative emotion in IBS patients and controls
Wound healing and signal transducer and activator of transcription 3 activity were elevated in CRHR2-overexpressing cells after urocortin 2 and IL-6 treatment, suggesting advanced healing progression
This study demonstrated that CRF2 Receptor Deficiency Eliminates the Long-Lasting Vulnerability of Motivational States Induced by Opiate Withdrawal.
D1 and CRF2 alpha receptors are capable of heterodimerization in living cells. D1 /CRF2 alpha receptor heteromerization might account, at least in part, for the complex physiological interactions established between dopamine and CRH.
no difference in placental expression between intrahepatic cholestasis of pregnancy and controls
not up-regulated by labor in placenta, fetal membranes, or myometrium
HSF2 element confers estrogen up-regulation of CRHR2 transcription and estrogen increases CRHR2 transcription via induction of HSF2 demethylation.
Results suggest CRHR-2 variants may affect risk for PTSD in women by attenuating the stress response and reducing symptoms of the disorder.
These results fail to provide support for an association of CRHR1 and CRHR2 with personality traits in a Japanese adult population.
The rate and extent of homologous CRF2(a) receptor desensitization is governed by agonist-specific mechanisms affecting G protein-coupled receptor kinase phosphorylation.
CRFR2 antagonist astressin-2B abrogated the effects of UCN2 on VSMCs. In conclusion, UCN2 is significantly associated with AAA and inhibits VSMC proliferation by inducing a G1 cell cycle arrest suggesting a plausible regulatory role in AAA pathogenesis
Data indicate that estrogen increased the abundance of the mRNA encoding CRH-R2 and an alternative splice variant encoding CRH-R1 in which exon 12 was deleted [CRH-R1(Delta12)].
The down-regulation of the CRF2 receptor in the distal/sigmoid biopsies of ulcerative colitis patients is indicative of change in CRF2 signalling associated with the process of inflammation.
In this study, mild blast-induced traumatic brain injury (mbTBI) did not alter CRFR1 gene expression in males or females. However, mbTBI disrupted CRFR2 gene expression in different limbic structures in males and females.
CRFR2-expressing neurons within the posterior bed nucleus of the stria terminalis (pBNST) send dense inhibitory projections to other stress-related brain regions. Local CRFR2 activation by urocortin 3 depolarized the cells, increased the neuronal input resistance and increased firing of action potentials. Optogenetic activation of CRFR2 neurons in the pBNST decreased anxiety and attenuated stress responses.
Urocortin 2 acts on gonadotrophs expressing the corticotropin-releasing factor type 2 receptor, and inhibits the production of gonadotropins in the pituitary gonadotropic tumor cells.
Results indicate that corticotropin releasing hormone receptor 2 (Crhr2) is highly expressed in cardiomyocytes, and cardiomyocyte-specific deletion of Crhr2 protected mice from pressure overload-induced cardiac dysfunction.
findings collectively suggest that the MeA Ucn3-CRF-R2 system modulates the ability of mice to cope with social challenges
Study suggests that selective CRF2 receptor agonists urocortin 2 and 3 could be used as a therapy in nicotine addiction.
Study demonstrated that CRF1 receptor-deficiency prolongs whereas CRF2 receptor-deficiency shortens the duration of recognition memory deficits induced by morphine discontinuation, unraveling opposite roles for the two known CRF receptor subtypes in cognitive dysfunction associated with opiate withdrawal.
results indicate that long-term UVA eye irradiation led to increased gp91phox-derived ROS in the brain and the increased expression of urocortin 2 and CRHR type 2, resulting in photoaging; however, further studies are needed to confirm these findings
Crhr2(-/-) mice showed increased mortality in the dextran sodium sulfate healing protocol
the inhibitory effect of CRFR2 signaling on insulin action is mediated by cAMP in a mammalian target of rapamycin-dependent manner.
This study aims to investigate the cellular localization of CRF and UCNs in the ileum and to explore whether and how this cellular expression is altered in conditions of intestinal Schistosoma mansoni-induced inflammation.
cPLA2 participates in CRHR1-induced apoptosis and CRHR2-inhibited apoptosis.
Data suggest that signal transduction via ghrelin and Crhr2 plays role in regulation of muscle glucose metabolism; Ghsr1a (ghrelin receptor type 1A) was not detected in mouse myoblast cell line (C2C12) investigated.
The receptors' binding specificity and structural studies were performed using full-length human CRFR1alpha and mouse CRFR2beta as well as fragments lacking the N-terminal extracellular domain.
estrogens act on ERalpha to up-regulate CRHR2 expression in cardiomyocytes.
These results provide initial evidence of a gender-independent and specific role for the CRF2 receptor in the motivational effects of opiate withdrawal.
Leptin regulates corticotropin-releasing factor and urocortin 2/3 mRNA in hypothalamic neurons.
stress-induced anorexia in A(y)/a mice may be associated with increased anorectic signals mediated by CRFR2 in the hypothalamus
Brain CRF2 receptors do not tonically promote anxiogenic-like behavior.
Corticotropin-releasing factor receptor 2 mediates sex-specific cellular stress responses.
These results suggest that a regulatory system exists in the bovine thyroid gland based on UCN, CRHR1 and CRHR2 and that UCN plays a role in the regulation of thyroid physiological functions through an autocrine/paracrine mechanism.
CRHR1 and CRHR2 are expressed in the bovine adrenal gland.
CRFr1 activation mediates intestinal mucosa barrier dysfunction and hypersecretion in early-weaned piglets, whereas CRFr2 activation may be responsible for novel protective properties in the porcine intestine in response to early life stress.
The protein encoded by this gene belongs to the G-protein coupled receptor 2 family, and the subfamily of corticotropin releasing hormone receptor. This receptor shows high affinity for corticotropin releasing hormone (CRH), and also binds CRH-related peptides such as urocortin. CRH is synthesized in the hypothalamus, and plays an important role in coordinating the endocrine, autonomic, and behavioral responses to stress and immune challenge. Studies in mice suggest that this receptor maybe involved in mediating cardiovascular homeostasis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
corticotropin releasing hormone receptor 2
, corticotropin-releasing factor receptor 2-like
, CRF2 receptor, beta isoform
, corticotropin-releasing factor receptor 2
, CRF 2 receptor
, corticotropin releasing factor receptor type 2 beta
, corticotropin-releasing factor 2
, corticotropin-releasing hormone receptor 2
, CRF-R 2
, CRH-R 2
, corticotrophin releasing hormone receptor 2
, corticotropin-releasing factor receptor subtype 2
, putative corticotropin-releasing hormone receptor type 2