|Antigen||Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 1 (KCNQ1) Antibodies|
|Epitope||AA 2-101 Alternatives|
|Reactivity||Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This KCNQ1 antibody is un-conjugated Alternatives|
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunoprecipitation (IP), Western Blotting (WB)
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Product Details anti-KCNQ1 AntibodyTarget Details KCNQ1 Application Details Handling Images
|Specificity||This antibody detects KCNQ1 K+ Channel at ~75 kDa.|
|Cross-Reactivity (Details)||Species reactivity (tested):Human, Mouse, Rat|
|Characteristics||Synonyms: KCNA8, KCNA9, KVLQT1, KQT-like 1, Potassium voltage-gated channel subfamily KQTmember 1, Voltage-gated potassium channel subunit Kv7.1, IKs producing slowvoltage-gated potassium channel subunit alpha KvLQT1|
|Purification||Protein G chromatography|
|Immunogen||Fusion protein amino acid 2-101 of human KCNQ1 (Kv7. 1, KvLQT1|
Target Details KCNQ1Product Details anti-KCNQ1 Antibody Application Details Handling Images back to top
|Alternative Name||KCNQ1 (KCNQ1 Antibody Abstract)|
|Background||Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient (1). They are present in the membranes that surround all biological cells because their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical forces. There are a few main classifications of gated ion channels. There are voltage- gated ion channels, ligandgated, other gating systems and finally those that are classified differently, having more exotic characteristics. The first are voltage- gated ion channels which open and close in response to membrane potential. These are then separated into sodium, calcium, potassium, proton, transient receptor, and cyclic nucleotide-gated channels, each of which is responsible for a unique role. Ligand-gated ion channels are also known as ionotropic receptors, and they open in response to specific ligand molecules binding to the extracellular domain of the receptor protein. The other gated classifications include activation and inactivation by second messengers, inward-rectifier potassium channels, calcium-activated potassium channels, two-pore-domain potassium channels, light-gated channels, mechano-sensitive ion channels and cyclic nucleotide-gate channels. Finally, the other classifications are based on less normal characteristics such as two-pore channels, and transient receptor potential channels (2). Specifically, Kv7.1 (KvLQT1) is a potassium channel protein coded for by the gene KCNQ1. Kv7.1 is present in the cell membranes of cardiac muscle tissue and in inner ear neurons (3) among other tissues. In the cardiac cells, Kv7.1 mediates the IKs (or slow delayed rectifying K+) current that contributes to the repolarization of the cell, terminating the cardiac action potential and thereby the heart's contraction (4, 5).Synonyms: IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1, KCNA8, KCNA9, KQT-like 1, KVLQT1, Potassium voltage-gated channel subfamily KQT member 1, Voltage-gated potassium channel subunit Kv7.1|
|Pathways||Negative Regulation of Hormone Secretion, Sensory Perception of Sound|
Application DetailsProduct Details anti-KCNQ1 Antibody Target Details KCNQ1 Handling Images back to top
Western blot: 1 - 10 μg/mL (if results are off, try using thelysate without boiling). Immunoprecipitation. Immunohistochemistry on frozen sections: 0.1 - 1.0 μg/mL (Perox).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-KCNQ1 Antibody Target Details KCNQ1 Application Details Images back to top
|Buffer||PBS pH 7.4, 50 % glycerol and 0.09 % sodium azide|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Storage||4 °C/-20 °C|
Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer. Avoidrepeated freezing and thawing.
Shelf life: one year from despatch.
|Expiry Date||12 months|