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|Antigen||Elongation Factor RNA Polymerase II-Like 3 (ELL3) Antibodies|
|Reactivity||Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This ELL3 antibody is conjugated to HRP Alternatives|
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
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Product Details anti-ELL3 AntibodyTarget Details ELL3 Application Details Handling Images
|Purification||Purified by Protein A.|
|Immunogen||KLH conjugated synthetic peptide derived from human ELL3|
|Plasmids, Primers & others|
Target Details ELL3Product Details anti-ELL3 Antibody Application Details Handling Images back to top
|Alternative Name||ELL3 (ELL3 Antibody Abstract)|
Eukaryotic RNA polymerase II mediates the synthesis of mature and functional messenger RNA. This is a multistep process, called the transcription cycle, that includes five stages: preinitiation, promoter, clearance, elongation and termination. Elongation is thought to be a critical stage for the regulation of gene expression. ELL (11-19 lysine-rich leukemia protein), also designated MEN, functions as an RNA polymerase II elongation factor that increases the rate of transcription by suppressing transient pausing by RNA polymerase II. It is also thought to regulate cellular proliferation. ELL is abundantly expressed in peripheral blood leukocytes, skeletal muscle, placenta and testis, with lower expression in spleen, thymus, heart, brain, lung, kidney, liver and ovary. ELL3 is a 397 amino acid nuclear protein that functions as an RNA polymerase II elongation factor that increases the rate of transcription by suppressing transient pausing by RNA polymerase II. Though similar to ELL and ELL2, ELL3 is exclusively expressed in testis.
Synonyms: B cell translocation gene 2, BTG family member 2, Btg2, BTG2_HUMAN, Nerve growth factor inducible anti prolerative, NGF inducible anti prolerative protein PC3, NGF-inducible anti-prolerative protein PC3, PC3, Pheochromacytoma cell 3, Protein BTG2, TIS21.
|Pathways||Negative Regulation of intrinsic apoptotic Signaling|
Application DetailsProduct Details anti-ELL3 Antibody Target Details ELL3 Handling Images back to top
|Restrictions||For Research Use only|
HandlingProduct Details anti-ELL3 Antibody Target Details ELL3 Application Details Images back to top
|Buffer||Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % Gentamicin.|
|Precaution of Use||This product contains Gentamicin sulfate: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.|
|Storage Comment||Store at 4°C|
|Expiry Date||12 months|