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Authors demonstrated that ER(alpha (show ESR1 Proteins)), GATA3 (show GATA3 Proteins) and FOXA1 (show FOXA1 Proteins) form a transcriptional complex with Ell3 to regulate IL-20 (show IL20 Proteins) expression in ER(+) breast cancer cells. FOXA1 (show FOXA1 Proteins) represses IL-20 (show IL20 Proteins) expression, whereas GATA3 (show GATA3 Proteins) and ER(alpha (show ESR1 Proteins)) activate it.
Selective expression of the transcription elongation factor (show TSFM Proteins) ELL3 in B cells prior to ELL2 (show ELL2 Proteins) drives proliferation and survival
Ell3 stabilizes p53 following cisplatin treatment via its effects on ubiquitin-dependent and -independent proteasomal degradation pathways in breast cancer cells.
Ell3 may play a critical role in promoting oncogenesis in breast cancer by regulating cell proliferation and cancer stem cell properties via the ERK1/2 signaling pathway
Study found that Ell3, a member of the Ell (show ELL Proteins) (eleven-nineteen lysine-rich leukemia gene) family of RNA Pol II (show POLR2F Proteins) elongation factors, occupies enhancers in embryonic stem cells.
The present results suggest that Ell3 promotes the differentiation of mouse embryonic stem cells by activating the expression of epithelial-mesenchymal transition-related genes and by suppressing p53 (show TP53 Proteins) expression.
Elongation factor that can increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA (By similarity).
RNA polymerase II elongation factor ELL3
, elongation factor RNA polymerase II-like 3
, RNA polymerase II elongation factor ELL3-like