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a vital role for the CLIC2 protein in maintaining normal cognitive function via its interaction with RyRs in the brain.
CLIC2 inhibited cardiac ryanodine receptor (show RYR2 ELISA Kits) Ca2 (show CA2 ELISA Kits)+ release channels in lipid bilayers when added to the cytoplasmic side of the channels and inhibited Ca2 (show CA2 ELISA Kits)+ release from cardiac sarcoplasmic reticulum vesicles
CLIC2 forms pH-dependent chloride channels in vitro with higher channel activity at low pH levels and that the channels are subject to redox regulation
Human CLIC2 was crystallized in 2 different forms, in presence of GSSH. Form A displayed P2(1)2(1)2(1) symmetry, with unit-cell parameters a=44.0, b=74.7, c=79.8 A. Form B displayed P2(1) symmetry, with unit-cell parameters a=36.0, b=66.9, c=44.1 A.
Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 2 is a member of the p64 family\; the protein is detected in fetal liver and adult skeletal muscle tissue. This gene maps to the candidate region on chromosome X for incontinentia pigmenti.
chloride intracellular channel protein 2
, chloride intracellular channel 2