anti-Rat (Rattus) Neural Precursor Cell Expressed, Developmentally Down-Regulated 4-Like antibody for ELISA

Recommended Neural Precursor Cell Expressed, Developmentally Down-Regulated 4-Like Antibody (supplied by: Log in to see )

Antigen
Neural Precursor Cell Expressed, Developmentally Down-Regulated 4-Like (NEDD4L) Antibodies
  • NEDD4-2
  • NEDD4.2
  • RSP5
  • hNEDD4-2
  • nedd4
  • nedd4-2
  • NEDD4
  • Nedd4-2
  • 1300012C07Rik
  • Nedd4b
  • neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
  • NEDD4L
  • neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase S homeolog
  • neural precursor cell expressed, developmentally down-regulated gene 4-like
  • NEDD4L
  • LOC776799
  • nedd4l.S
  • Nedd4l
Epitope
pSer342
15
10
8
8
7
4
3
3
2
2
2
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
65
61
37
6
5
5
5
4
3
1
1
1
1
1
Host
Rabbit
75
7
Clonality
Polyclonal
Conjugate
Un-conjugated
4
4
4
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Application
ELISA, Western Blotting (WB)
60
38
19
13
7
6
4
2
1
Supplier
Log in to see
Supplier Product No.
Log in to see
Request

Get this product for free

Submit your validation data for this product and get a full refund. I want to validate this product

Learn more

Available images

Catalog No. ABIN6268178
$ 450.00
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN6268594 ELISA WB Rabbit IgG Log in to see Polyclonal 0
1 ABIN5693274 ELISA WB Rabbit AA 703-975 Log in to see Polyclonal 0
1 ABIN5704012 ELISA IHC WB Rabbit IgG Log in to see Polyclonal 0
1 ABIN6116389 ELISA WB Rabbit IgG AA 289-494 Log in to see Polyclonal 0
1 ABIN2916731 ELISA IHC WB Rabbit IgG Log in to see Polyclonal 0
1 ABIN2430545 IHC ELISA Rabbit IgG Log in to see Polyclonal 0
1 ABIN2423881 IHC ELISA Rabbit IgG Log in to see Polyclonal 0
1 ABIN1089299 IHC ELISA WB Rabbit IgG Log in to see Polyclonal 0
1 ABIN5647890 ELISA WB Rabbit IgG Log in to see Polyclonal 0
1 ABIN5929404 ELISA IHC WB Rabbit IgG Log in to see Polyclonal 0

General

Antigen Neural Precursor Cell Expressed, Developmentally Down-Regulated 4-Like (NEDD4L) Antibodies
Epitope pSer342
(15), (10), (8), (8), (7), (4), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Human, Mouse (Murine), Rat (Rattus)
(65), (61), (37), (6), (5), (5), (5), (4), (3), (1), (1), (1), (1), (1)
Host Rabbit
(75), (7)
Clonality
Polyclonal
Conjugate Un-conjugated
(4), (4), (4), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application ELISA, Western Blotting (WB)
(60), (38), (19), (13), (7), (6), (4), (2), (1)
Supplier Log in to see

Product details

Target Details Application Details Handling Images
Specificity Phospho-NEDD4L (Ser342) Antibody detects endogenous levels of NEDD4L only when phosphorylated at Ser342
Cross-Reactivity Human, Mouse (Murine), Rat (Rattus)
Purification The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
Immunogen A synthesized peptide derived from human NEDD4L around the phosphorylation site of Ser342
Isotype IgG

Target Details

Product details Application Details Handling Images back to top
Antigen
Alternative Name NEDD4L (NEDD4L Antibody Abstract)
Background

Description: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits TGF-beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, SCN2A/Nav1.2, SCN3A/Nav1.3, SCN5A/Nav1.5, SCN9A/Nav1.7, SCN10A/Nav1.8, KCNA3/Kv1.3, KCNH2, EAAT1, KCNQ2/Kv7.2, KCNQ3/Kv7.3 or CLC5 (PubMed:26363003, PubMed:27445338). Promotes ubiquitination and degradation of SGK1 and TNK2. Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 (PubMed:25631046). Plays a role in dendrite formation by melanocytes (PubMed:23999003). Involved in the regulation of TOR signaling (PubMed:27694961). Ubiquitinates and regulates protein levels of NTRK1 once this one is activated by NGF (PubMed:27445338).

Gene: NEDD4L

Molecular Weight 112kDa
Gene ID 23327
UniProt Q96PU5
Pathways Negative Regulation of Transporter Activity

Application Details

Product details Target Details Handling Images back to top
Application Notes WB 1:500-1:2000
Restrictions For Research Use only

Handling

Product details Target Details Application Details Images back to top
Format Liquid
Concentration 1 mg/mL
Buffer Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20 °C.Stable for 12 months from date of receipt
Expiry Date 12 months

Images

Product details Target Details Application Details Handling back to top
Supplier Images
Western Blotting (WB) image for anti-Neural Precursor Cell Expressed, Developmentally Down-Regulated 4-Like (NEDD4L) (pSer342) antibody (ABIN6268178) Western blot analysis of Phospho-NEDD4L (Ser342) in lysates of K562?, using Phospho-...