Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
Show all synonyms
Select your origin of interest
The presence of two different isoforms in the myocardium close to the insertion of pacing is suggestive of a differential state-specific expression of A2AR in cardiac tissue.
Ex vivo lung perfusion with adenosine A2A receptor agonist allows prolonged cold preservation of lungs donated after cardiac death.
Adenosine A2A receptor contributes to ischemic brain damage in newborn piglet.
Pretreatment strategy with adenosine A2A receptor agonist attenuates reperfusion injury in a preclinical porcine lung transplantation model.
mRNA for adenosine A(1), A(2A), A(2B (show ADRA2B Proteins)), and A(3) receptors was expressed in arterioles and venules. Protein for A(1), A(2A), and A(2B (show ADRA2B Proteins)), but not A(3), was detected in both microvessel types and was further demonstrated on vascular endothelial cells
Study reveals presence of adenosine A(2A) and A(2B (show ADRA2B Proteins)) receptors as well as a role for them in lacrimal gland secretion, and especially in synergy with purinergic and cholinergic stimulation.
Report prognostic impact of ADORA2A expression in non-small lung cancers.
genetic association studies in population in Germany: Data suggest that an SNP in ADORA2A (1976T/C, rs5751876) is associated with interoceptive (resting) and exteroceptive (executive function/task-based) processing in frontal lobe and insular cortex neural networks. Facilitated processing of interoceptive/exteroceptive information in salience network is suggested to promote development of anxiety and anxiety disorders.
A2A receptor stimulation promotes collagen type III synthesis via the activation of canonical and non-canonical beta-catenin (show CTNNB1 Proteins), consistent with a role for A2A receptors in dermal fibrosis and scarring.
It is significantly associated with hippocampal volume and the minor allele of rs9608282 in ADORA2A is associated with larger hippocampal volumes and better memory.
Study corroborated results from a previous report that described interactions between ADORA2A and CYP1A2 (show CYP1A2 Proteins) polymorphisms and coffee consumption in Parkinson's disease.
However, the contribution of the A2AR to the control of impulsive reward seeking remains unknown. Using mice that were exposed to differential reward of low rate (DRL) schedules during Pavlovian-conditioning, second-order schedule discrimination, and the 5-choice serial reaction time task (5-CSRTT), we demonstrate that deficits of A2AR function promote impulsive responses.
Western blot analysis indicates that the A2A receptor is more abundant in the hippocampus of medial temporal lobe epilepsy patients compared to control individuals. Immunoreactivity against the A2A receptor predominates in astrocytes staining positively for the glial fibrillary acidic protein (show GFAP Proteins).
Results suggest that the combination of the ADORA2A rs2298383TT and MTHFR (show MTHFR Proteins) 1298AC-677CT genotypes might lead to a low risk of nodule formation in patients treated with methotrexate.
results unveil intracellular signaling pathways targeted by the A2AR, some of which might be key in modulating neutrophil functions.
Calcium modulates calmodulin-ACTN1 (show ACTN1 Proteins) interaction with and agonist-dependent internalization of the adenosine A2A receptor.
The astrocytic Lrp4 (show CORIN Proteins) plays an important role in ischemic brain injury response. Lrp4 (show CORIN Proteins) deficiency in astrocytes seems to be protective in response to ischemic brain injury, likely because of the increased ATP release and adenosine-A2AR signaling.
the potential effects of the A2A adenosine receptor (A2AR) antagonist SCH (show NF2 Proteins) 5826 (SCH (show NF2 Proteins)) and agonist CGS 21680 (CGS) on behavior (self-grooming), hot plate test results, and expression levels of IL-17A (show IL17A Proteins)(+), RORgammat(+), Foxp3 (show FOXP3 Proteins)(+), and IL-10 (show IL10 Proteins)(+) in CD4 (show CD4 Proteins)(+) T spleen cells in BTBR and C57BL/6 (B6) mice, were investigated.
Absence of A2AAR increases cochlear resistance to acoustic trauma.
Behavioral, anatomical and neurochemical studies to assess psychotic-like symptoms in adult male and female A2AR KO and wild-type littermates. Results bolster the adenosine hypothesis of schizophrenia by demonstrating behavioral and anatomical alterations associated with the specific deletion of adenosine A2AR. These findings resemble most of the relevant phenotype features of the human disorder.
Adenosine receptor A2A drives pathological angiogenesis in the oxygen-induced retinopathy mouse model by promoting glycolysis in endothelial cells via the ERK (show EPHB2 Proteins)/Akt (show AKT1 Proteins)/HIF-1alpha (show HIF1A Proteins) pathway.
it is concluded that the anxiolytic-like activities of rubimetide and typical agonist peptides of the FPR2 (show FPR2 Proteins) were mediated successively by the PGD2 (show PTGDS Proteins)-DP1 (show REEP5 Proteins) receptor, adenosine-A2A receptor, and GABA-GABAA (show GABRg1 Proteins) receptor systems downstream of the FPR2 (show FPR2 Proteins).
Study focused on the impact of A2A receptor deletion (A2A receptor knockout, A2AKO) on motivation for social exploration. Although A2AKO mice showed an anxious profile, they displayed higher levels of sociability and were less sensitive to social novelty. c-Fos immunoreactivity in A2AKO mice was higher in anterior cingulate and amygdala compared to wild type mice.
Data indicate A2ARs exert minor effects in un-stressed myocardium and selectively suppress NFkappaB and JAK (show JAK3 Proteins)-STAT (show STAT1 Proteins) signalling and cardiac injury without influencing cardiac depression in endotoxemia.
The three receptor sets considered (mAChR (show CHRM3 Proteins), AR and TrkB (show NTRK2 Proteins) receptors) intervene in modulating the conditions of the competition between nerve endings.
High A2aR expression is associated with Melanoma Metastasis.
Adenosine A2A receptor immunoreactivity is localized at the highest levels of the striatum and external globus pallidus.
Activation of adenosine A(2A) receptors inhibited ROS (show ROS1 Proteins) production by LPS (show IRF6 Proteins)-stimulated equine neutrophils in a cAMP-dependent manner.
This gene encodes a protein which is one of several receptor subtypes for adenosine. The activity of the encoded protein, a G-protein coupled receptor family member, is mediated by G proteins which activate adenylyl cyclase. The encoded protein is abundant in basal ganglia, vasculature and platelets and it is a major target of caffeine.
adenosine A2a receptor
, adenosine receptor A2a
, adenosine receptor A2a.1
, A2a adenosine receptor
, adenosine receptor A2a-like
, adenosine receptor subtype A2a
, A2a, Rs
, Adenosine A2a-receptor