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The presence of two different isoforms in the myocardium close to the insertion of pacing is suggestive of a differential state-specific expression of A2AR in cardiac tissue.
Ex vivo lung perfusion with adenosine A2A receptor agonist allows prolonged cold preservation of lungs donated after cardiac death.
Adenosine A2A receptor contributes to ischemic brain damage in newborn piglet.
Pretreatment strategy with adenosine A2A receptor agonist attenuates reperfusion injury in a preclinical porcine lung transplantation model.
Activation of adenosine A(2A) receptors inhibited ROS (show ROS1 Proteins) production by LPS (show IRF6 Proteins)-stimulated equine neutrophils in a cAMP-dependent manner.
Adenosine A2A receptor immunoreactivity is localized at the highest levels of the striatum and external globus pallidus.
This study reported associations between the c.1083T>C polymorphism in the adenosine A2A receptor gene (ADORA2A) and sleep variables
Enhancement of inosine-mediated A2AR signaling through positive allosteric modulation has been reported.
These data indicate that low [Na(+)] is required to allow large agonist-induced structural changes in A2AR, and that patterns of sidechain dynamics substantially differ between agonist (NECA) and inverse agonist (ZM241385) bound receptors, with the inverse agonist suppressing fast picosecond-nanosecond timescale motions at the G protein binding site.
Low adenosine A2a receptor expression is associated with ulcerative colitis.
Results demonstrate that A2AR act on GR nuclear translocation and GR-dependent transcriptional regulation which suggest that A2AR is a major regulator of GR function and that this functional interconnection may be a trigger to age-related memory deficits.
the present study indicates that A2bR (show ADORA2B Proteins) may play a potential oncogenic role in BUC progression and act as a potential biomarker to identify BUC patients with poor clinical outcomes.
Report prognostic impact of ADORA2A expression in non-small lung cancers.
genetic association studies in population in Germany: Data suggest that an SNP in ADORA2A (1976T/C, rs5751876) is associated with interoceptive (resting) and exteroceptive (executive function/task-based) processing in frontal lobe and insular cortex neural networks. Facilitated processing of interoceptive/exteroceptive information in salience network is suggested to promote development of anxiety and anxiety disorders.
A2A receptor stimulation promotes collagen type III synthesis via the activation of canonical and non-canonical beta-catenin (show CTNNB1 Proteins), consistent with a role for A2A receptors in dermal fibrosis and scarring.
It is significantly associated with hippocampal volume and the minor allele of rs9608282 in ADORA2A is associated with larger hippocampal volumes and better memory.
importance for MC5r (show MC5R Proteins) and A2Ar expression in EAU to promote the induction of protective regulatory immunity, and the expression of MC5r (show MC5R Proteins) and A2Ar on human immune cells, suggests that it may be possible to utilize the melanocortin-adenosinergic pathways to induce protective immunity in uveitic patients
Body weight was significantly smaller in A2AR-KO mice at the age of 6 months
A2AR activation enhances its interaction with endothelial glutamate (show GRIN1 Proteins) transporters. Inhibition of A2AR rescued dysfunction of brain endothelial glutamate (show GRIN1 Proteins) transporters.
The astrocytic Lrp4 (show CORIN Proteins) plays an important role in ischemic brain injury response. Lrp4 (show CORIN Proteins) deficiency in astrocytes seems to be protective in response to ischemic brain injury, likely because of the increased ATP release and adenosine-A2AR signaling.
the potential effects of the A2A adenosine receptor (A2AR) antagonist SCH (show NF2 Proteins) 5826 (SCH (show NF2 Proteins)) and agonist CGS 21680 (CGS) on behavior (self-grooming), hot plate test results, and expression levels of IL-17A (show IL17A Proteins)(+), RORgammat(+), Foxp3 (show FOXP3 Proteins)(+), and IL-10 (show IL10 Proteins)(+) in CD4 (show CD4 Proteins)(+) T spleen cells in BTBR and C57BL/6 (B6) mice, were investigated.
Absence of A2AAR increases cochlear resistance to acoustic trauma.
Behavioral, anatomical and neurochemical studies to assess psychotic-like symptoms in adult male and female A2AR KO and wild-type littermates. Results bolster the adenosine hypothesis of schizophrenia by demonstrating behavioral and anatomical alterations associated with the specific deletion of adenosine A2AR. These findings resemble most of the relevant phenotype features of the human disorder.
Adenosine receptor A2A drives pathological angiogenesis in the oxygen-induced retinopathy mouse model by promoting glycolysis in endothelial cells via the ERK (show EPHB2 Proteins)/Akt (show AKT1 Proteins)/HIF-1alpha (show HIF1A Proteins) pathway.
it is concluded that the anxiolytic-like activities of rubimetide and typical agonist peptides of the FPR2 (show FPR2 Proteins) were mediated successively by the PGD2 (show PTGDS Proteins)-DP1 (show REEP5 Proteins) receptor, adenosine-A2A receptor, and GABA-GABAA (show GABRg1 Proteins) receptor systems downstream of the FPR2 (show FPR2 Proteins).
Study focused on the impact of A2A receptor deletion (A2A receptor knockout, A2AKO) on motivation for social exploration. Although A2AKO mice showed an anxious profile, they displayed higher levels of sociability and were less sensitive to social novelty. c-Fos immunoreactivity in A2AKO mice was higher in anterior cingulate and amygdala compared to wild type mice.
Study reveals presence of adenosine A(2A) and A(2B (show ADRA2B Proteins)) receptors as well as a role for them in lacrimal gland secretion, and especially in synergy with purinergic and cholinergic stimulation.
This gene encodes a protein which is one of several receptor subtypes for adenosine. The activity of the encoded protein, a G-protein coupled receptor family member, is mediated by G proteins which activate adenylyl cyclase. The encoded protein is abundant in basal ganglia, vasculature and platelets and it is a major target of caffeine.
adenosine A2a receptor
, adenosine receptor A2a
, adenosine receptor A2a.1
, adenosine receptor subtype A2a
, A2a, Rs
, Adenosine A2a-receptor
, adenosine receptor A2a-like