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We studied the function of LARG in murine and human megakaryocytes and platelets with Larg knockout (KO), shRNA-mediated knockdown and small molecule-mediated inhibition. We found that LARG is important for human, but not murine, megakaryocyte maturation.
that leukemia-associated Rho guanine-nucleotide exchange factor can be directly phosphorylated by cyclin-dependent kinase 1 (show CDK1 Proteins)
Two related guanine nucleotide exchange factors (GEFs), PDZ-RhoGEF (show ARHGEF11 Proteins) and leukemia-associated RhoGEF (LARG), use their PDZ domains to bind class B plexins and play critical roles in signaling.
this study identified a novel association between IOP and ARHGEF12.
TGF-beta (show TGFB1 Proteins) regulates LARG and GEF-H1 (show ARHGEF2 Proteins) during epithelial-mesenchymal transition to affect stiffening response to force and cell invasion.
LARG is a novel and temporally distinct Rho Guanine Nucleotide Exchange Factor required for completion of abscission.
Data indicate that ICAM-1 (show ICAM1 Proteins) signaling activates leukemia-associated Rho guanine nucleotide exchange factor (LARG), also known as Rho GEF (show SLC2A4RG Proteins) 12 (ARHGEF12).
Agonist-induced Ca2 (show CA2 Proteins)+ sensitization in smooth muscle: redundancy of Rho guanine nucleotide exchange factors (RhoGEFs) and response kinetics, a caged compound study.
RhoGEF (show ARHGEF11 Proteins) activity of p210 BCR/ABL (show ABL1 Proteins) directly contributes to transforming activity, and may account for the difference in disease outcome associated with p190 (show CNTNAP1 Proteins) BCR/ABL (show ABL1 Proteins) and p210 BCR/ABL (show ABL1 Proteins).
NIS enhanced cell migration and invasion by binding to leukemia-associated RhoA (show RHOA Proteins) guanine exchange factor
Data found an inverse relationship between the expression of miR (show MLXIP Proteins)-660 and ARHGEF12 in both gain- and loss-of-function studies: overexpression of miR (show MLXIP Proteins)-660 declined the mRNA and protein expressions of ARHGEF12 in C2C12 cells differentiation; however, knockdown of miR (show MLXIP Proteins)-660 had completely opposite results.
This study demonstrated an almost 100-fold higher agonist sensitivity of the Galpha13 (show GNA13 Proteins) LARG interaction compared to the Galpha13 (show GNA13 Proteins) activation in the absence of LARG.
LARG may play a housekeeper role in regulating constitutive RhoA (show RHOA Proteins) activity. Its role in regulating platelet function may principally be through RhoA (show RHOA Proteins)-independent pathways.
The increase in LARG expression was accompanied by a significant increase in ACh (show FGFR3 Proteins)-stimulated Rho kinase (show ROCK2 Proteins) and ZIP kinase (show DAPK3 Proteins) activities, and sustained muscle contraction
PDZ-RhoGEF and LARG are essential for embryonic development and provide a link between thrombin and LPA receptors and Rho activation.
LARG is activated by the Src family tyrosine kinase Fyn, whereas GEF-H1 catalytic activity is enhanced by ERK downstream of a signalling cascade that includes FAK and Ras
new insight into the mechanism by which p115RhoGEF (show ARHGEF1 Proteins) is activated by Galpha (show SUCLG1 Proteins)(13).
S1PR2 (show S1PR2 Proteins)-dependent activation of RhoA (show RHOA Proteins) in smooth muscle cells is mediated by LARG and that this signaling mechanism promotes the differentiated SMC (show DYM Proteins) phenotype.
cDNA of LARG (leukemia-associated guanine nucleotide exchange factor) was identified, and its gene expression was observed to be downregulated under clinorotation, which subsequently resulted in the repression of RhoA (show RHOA Proteins) activation
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli working through G protein-coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This protein has been observed to form a myeloid/lymphoid fusion partner in acute myeloid leukemia. Two transcript variants encoding different isoforms have been found for this gene.
guanine nucleotide exchange factor
, Rho guanine nucleotide exchange factor (GEF) 12
, rho guanine nucleotide exchange factor 12-like
, leukemia-associated RhoGEF
, leukemia-associated rho guanine nucleotide exchange factor
, rho guanine nucleotide exchange factor 12
, leukemia-associated Rho guanine-nucleotide exchange factor
, leukemia-associated Rho guanine nucleotide exchange factor