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Combined treatment with the histone deacetylase (show HDAC1 Proteins) inhibitors (HDACi) suberoylanilide hydroxamic acid plus 5-fluorouracil (5-FU) and oxaliplatin (Oxa) reduced the level of HDAC2 expression in HT-29 cells.
miR (show MLXIP Proteins)-223 controls the expression of CX3CL1 (show CX3CL1 Proteins) by targeting HDAC2 in chronic obstructive pulmonary disease patients and mouse models of the disease.
Data show that BRCA2 was required for HDAC2/3 association with acetylated BubR1 in nocodazole (Noc)-arrested cells.
study defines two classes of HDAC2 targets in human cells, with a dependence of HDAC1 (show HDAC1 Proteins) on HDAC2 at one class of targets, and distinguishes unique functions for HDAC2
This study demonstrated that the Expression of HDAC2 Transcript Is Reduced in Dorsolateral Prefrontal Cortex of Patients with Schizophrenia.
The findings suggest that miR (show MLXIP Proteins)-455-3p plays a critical role during chondrogenesis by directly targeting HDAC2/8 and promoting histone H3 (show HIST3H3 Proteins) acetylation.
report the interaction between CFTR (show CFTR Proteins) and HDAC2, and its involvement in the development of Ph+ leukemia
Results indicate that HCV core induced epithelial-mesenchymal transition (EMT (show ITK Proteins)) by interacting with the transcriptional repressor complex Snail (show SNAI1 Proteins)/HDAC1 (show HDAC1 Proteins)/2 at the E-cadherin (show CDH1 Proteins) promoter, which led to E-cadherin (show CDH1 Proteins) repression and increased invasiveness of hepatoma cells.
Coexpression of SALL4 with HDAC1 and/or HDAC2 was associated with PTEN underexpression and a poor prognosis in hepatocellular carcinoma.
Acetylation-dependent control of global poly(A) RNA degradation by CBP/p300 (show CREBBP Proteins) and HDAC1-HDAC2 (show HDAC1 Proteins) has been described.
Members of the SIN3A/HDAC2 corepressor complex are enriched in an extended NANOG interactome.
Treatment of the haplotype Npr1 (show NPR1 Proteins)(+/-) mice with histone deacetylase (show HDAC1 Proteins) inhibitors significantly lowered blood pressure and reduced the renal inflammation and fibrosis involving the interactive roles of HDAC1 (show HDAC1 Proteins)/2, NF-kappaB (show NFKB1 Proteins) (p65 (show NFkBP65 Proteins)), and STAT1 (show STAT1 Proteins).
Our study indicates that ischemia-induced histone deacetylase 2 upregulation from 5 to 7 d after stroke mediates the secondary functional loss by reducing survival and neuroplasticity of peri (show POSTN Proteins)-infarct neurons as well as augmenting neuroinflammation. Thus, precisely targeting histone deacetylase 2 in the window phase provides a novel therapeutic strategy for stroke recovery.
Taken together, Fam60a is an essential core subunit of a variant Sin3a (show SIN3A Proteins)-Hdac (show HDAC3 Proteins) complex in embryonic stem cells that is required to promote rapid proliferation and prevent unscheduled differentiation.
provide new insight into the upstream regulation of Sap90/Psd95 (show DLG4 Proteins)-associated protein 3 (show HSPB3 Proteins) and establish the essential role of striatal Hdac1 (show HDAC1 Proteins), Hdac2 and MeCP2 for suppression of repetitive behaviors
this study shows that infection-induced miR (show MLXIP Proteins)-21 promotes severe, steroid-insensitive allergic airway disease by suppressing HDAC2
observations suggest that Methamphetamine may induce large-scale transcriptional changes in the Nuc (show SREBF2 Proteins). Accumbens by regulating the expression of several histone deacetylases in part, via HDAC2-dependent mechanisms.
This gene product belongs to the histone deacetylase family. Histone deacetylases act via the formation of large multiprotein complexes, and are responsible for the deacetylation of lysine residues at the N-terminal regions of core histones (H2A, H2B, H3 and H4). This protein forms transcriptional repressor complexes by associating with many different proteins, including YY1, a mammalian zinc-finger transcription factor. Thus, it plays an important role in transcriptional regulation, cell cycle progression and developmental events. Alternative splicing results in multiple transcript variants.
YY1-associated factor 1
, transcriptional regulator homolog RPD3
, YY1 transcription factor-binding protein
, histone deacetylase-2