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This study identified a new mitochondria reprogramming pathway influencing breast cancer progression through SH3GL2 and MFN2 (show MFN2 Proteins). These proteins were frequently lost in breast cancer, which was traceable in the circulating exosomes.
Endophilin-1 was a direct and functional downstream target of miR (show MLXIP Proteins)-107.
Methylation status of SH3GL2 gene was associated with the TNM (show ODZ1 Proteins) staging and HPV infection status of vulvar squamous cell carcinoma.
Endophilin-1 positively regulated blood-brain barrier permeability via the EGFR (show EGFR Proteins)-JNK (show MAPK8 Proteins) signaling pathway in hCMEC/D3 cells, which would provide an experimental basis for further research on endophilin-1 mediated the opening of blood-brain barrier .
these results reveal a novel function of postsynaptic endophilin A1 in spine morphogenesis, stabilization and synaptic function through the regulation of p140Cap (show SRCIN1 Proteins)
Data indicate that the presence of the susceptible G allele in SNP rs1049430 is associated with the inactivation of SH3-domain GRB2-like 2 protein (SH3GL2) and could be used as a prognostic marker of head and neck squamous cell carcinoma (HNSCC).
study described that endophilin-1 is expressed in hCMEC/D3 cells where it regulates the permeability of blood-brain barrier by altering the expression of ZO-1 and occludin via the EGFR-ERK1/2 pathway
miR (show MLXIP Proteins)-330 negatively regulated the expression of SH3GL2 in GSCs, which promoted the oncogenic progression of GSCs through activating ERK (show EPHB2 Proteins) and PI3K (show PIK3CA Proteins)/AKT (show AKT1 Proteins) signaling pathways.
these findings identify loss of Sh3gl2 as a frequent event in Urothelial carcinoma (UC) development that promotes disease progression.
this study suggests a novel mechanism in which Lpd mediates EGFR endocytosis via Mena downstream of endophilin.
Transcriptional analysis of endophilin-A mutant mice, complemented by proteomics, highlighted ataxia- and protein-homeostasis-related genes and revealed upregulation of the E3-ubiquitin ligase (show MUL1 Proteins) FBXO32/atrogin-1 (show FBXO32 Proteins) and its transcription factor FOXO3A (show FOXO3 Proteins).
retrolinkin is a binding partner of endophilin A1 and that both proteins are required for BDNF (show BDNF Proteins)-induced dendrite outgrowth
Data report that the parkin ubiquitin-like domain binds SH3 domains from endocytic BAR proteins such as endophilin-A with an affinity comparable to proline-rich domains from well-established SH3 partners.
Tip-to-tip interactions between the BAR domains in a trigonal crystal form of Snx9 (show SNX9 Proteins)(PX-BAR) reminiscent of functionally important interactions described for F-BAR domains.
Results sugest that reduced or defective OPHN1 (show OPHN1 Proteins) signaling impairs synaptic vesicle cycling at hippocampal synapses.
interacts with synaptojanin and dynamin I\; may be involved in synaptic vesicle recycling
Endophilin A1 BAR domain
, SH3 domain protein 2A
, SH3 domain-containing GRB2-like protein 2
, bA335L15.1 (SH3-domain GRB2-like 2)
, endophilin A1
, endophilin I
, SH3 domain-containing GRB2-like protein 1